Hemogasometry, cardiac biomarkers and blood metabolites in goats with experimentally induced acute ruminal lactic acidosis

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorPostgraduate Program in Sanity and Reproduction of Ruminants-
Autor(es): dc.contributorPostgraduate Program in Veterinary Medicine-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorFederal Rural University of Pernambuco (UFRPE)-
Autor(es): dc.creatorRibeiro, Ana Clara Sarzedas-
Autor(es): dc.creatorda Conceição, Ângela Imperiano-
Autor(es): dc.creatorSoares, Gliére Silmara Leite-
Autor(es): dc.creatorCorreia, Felipe Rosendo-
Autor(es): dc.creatorde Oliveira-Filho, José Paes [UNESP]-
Autor(es): dc.creatorSoares, Pierre Castro-
Autor(es): dc.creatorde Mendonça, Carla Lopes-
Autor(es): dc.creatorAfonso, José Augusto Bastos-
Data de aceite: dc.date.accessioned2022-02-22T00:26:28Z-
Data de disponibilização: dc.date.available2022-02-22T00:26:28Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.smallrumres.2020.106187-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/199106-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/199106-
Descrição: dc.descriptionWhereas that acute ruminal lactic acidosis (ARLA) can cause secondary metabolic disorders and some degree of cardiovascular damage, the present study aimed to evaluate the hemogasometry, concentrations of the creatine kinase isoenzyme MB (CKMB), cardiac troponin I (cTnI), and blood variables in goats with experimental ARLA. The disease was induced in five goats through intraruminal supply of 15 g sucrose/Kg live weight. Before induction and 4 h, 8 h, 12 h, 24 h, 48 h, 72 h, and 168 h post-induction (PI), clinical examination, ruminal fluid analysis, hemogasometry analysis, and measurement of AST, CK, CK-MB, cTnI, GGT, LDH, and L-lactate in the blood of these animals were performed. The experimental model used caused clinical alterations characteristic of ARLA in goats from 4 h PI. The characteristics of the ruminal fluid also changed from 4 h PI, becoming to milky appearance, acidic odor, aqueous consistency and a reduced population of protozoa. The ruminal pH decreased (P <.0001) from 4 h to 48 h PI, with a lower average value of 4.70–12 h PI. Hemogasometry revealed that acid-base and electrolyte imbalances occurred, with transient metabolic alkalosis preceding a metabolic acidosis. The blood concentration of Na+ increased (P <.0001), whereas the concentration of K+ presented an initial elevation followed by hypokalemia (P = 0.0025). After induction, there was an increase in L-lactate (P = 0.0039) and LDH (P = 0.0005) and cTnI, CK-MB, CK, AST and GGT did not change (P> 0.05). Therefore, the evaluation of blood biochemistry aided in the monitoring of systemic changes resulting from ARLA in goats and the clinical condition induced by this experimental model did not cause cardiac injury.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFederal Rural University of Pernambuco (UFRPE) Garanhuns Academic Unit Postgraduate Program in Sanity and Reproduction of Ruminants, Av. Bom Pastor, s/n-
Descrição: dc.descriptionFederal Rural University of Pernambuco (UFRPE) Postgraduate Program in Veterinary Medicine, Rua Dom Manoel de Medeiros, s/n, Campus Dois Irmãos-
Descrição: dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP) Department of Clinical Veterinary Sciences Faculty of Veterinary Medicine and Animal Science, Campus de Botucatu, Rua Prof. Dr. Walter Maurício Correa, s/n-
Descrição: dc.descriptionFederal Rural University of Pernambuco (UFRPE) Department of Veterinary Medicine, Rua Dom Manoel de Medeiros, s/n, Campus Dois Irmãos-
Descrição: dc.descriptionGaranhuns Bovine Clinic Federal Rural University of Pernambuco (UFRPE), Av. Bom Pastor, s/n, CP 152-
Descrição: dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP) Department of Clinical Veterinary Sciences Faculty of Veterinary Medicine and Animal Science, Campus de Botucatu, Rua Prof. Dr. Walter Maurício Correa, s/n-
Idioma: dc.languageen-
Relação: dc.relationSmall Ruminant Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAcid-base balance-
Palavras-chave: dc.subjectBlood gas-
Palavras-chave: dc.subjectCardiac troponin I-
Palavras-chave: dc.subjectCreatine kinase MB-
Palavras-chave: dc.subjectElectrolytes-
Palavras-chave: dc.subjectRuminal acidosis-
Título: dc.titleHemogasometry, cardiac biomarkers and blood metabolites in goats with experimentally induced acute ruminal lactic acidosis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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