Mechanochemical synthesis, characterization and thermoanalytical study of a new curcumin derivative

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorde Moura, Aniele [UNESP]-
Autor(es): dc.creatorGaglieri, Caroline [UNESP]-
Autor(es): dc.creatorda Silva-Filho, Luiz Carlos [UNESP]-
Autor(es): dc.creatorCaires, Flávio Junior [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:26:27Z-
Data de disponibilização: dc.date.available2022-02-22T00:26:27Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s10973-020-10000-w-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/199096-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/199096-
Descrição: dc.descriptionThe curcumin is the major constituent of turmeric plant (Curcuma longa), which presents several biological activities such as antioxidant, bactericidal, anti-inflammatory and antitumor. An interesting strategy to improve its properties is to synthetize curcumin derivatives. Thus, the synthesis of a new curcumin derivative (DCUR) with 4-carboxybenzaldehyde (4-CBA) becomes interesting, which occurs by a Knoevenagel reaction, a common methodology used to synthesize curcumin analogues. The synthesis was carried out by the mechanochemical method, which is an efficient green method for the synthesis of organic compounds. The most efficient grinding time for mechanochemical synthesis was determined using PXRD and DSC techniques. 1H NMR, DEPTQ and FTIR analyses confirmed the structure of DCUR. This new methodology is more efficient (at least 5×), and cleaner than usual methods described in the literature to obtain a new compound by Knoevenagel reaction. The TG–DTA, DSC and DSC-microscopy techniques were used to confirm the formation of the compound and to study its thermal behavior. Moreover, the thermoanalytical of 4-CBA showed that this compound presents a reversible solid–solid phase transition.-
Descrição: dc.descriptionChemistry Department School of Sciences UNESP - São Paulo State University-
Descrição: dc.descriptionChemistry Department School of Sciences UNESP - São Paulo State University-
Idioma: dc.languageen-
Relação: dc.relationJournal of Thermal Analysis and Calorimetry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subject4-Carboxybenzaldehyde-
Palavras-chave: dc.subjectCurcuminoids-
Palavras-chave: dc.subjectKnoevenagel reaction-
Palavras-chave: dc.subjectMechanochemistry-
Palavras-chave: dc.subjectSolid–solid phase transition-
Palavras-chave: dc.subjectThermal analysis-
Título: dc.titleMechanochemical synthesis, characterization and thermoanalytical study of a new curcumin derivative-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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