Weighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattle

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Federal de Goiás (UFG)-
Autor(es): dc.contributorEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorInc.-
Autor(es): dc.contributorNational Association of Breeders and Researchers (ANCP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorAnimal Science Institute-
Autor(es): dc.creatorBrunes, Ludmilla C.-
Autor(es): dc.creatorBaldi, Fernando [UNESP]-
Autor(es): dc.creatorLopes, Fernando B.-
Autor(es): dc.creatorLôbo, Raysildo B.-
Autor(es): dc.creatorEspigolan, Rafael-
Autor(es): dc.creatorCosta, Marcos F. O.-
Autor(es): dc.creatorStafuzza, Nedenia B.-
Autor(es): dc.creatorMagnabosco, Cláudio U.-
Data de aceite: dc.date.accessioned2022-02-22T00:26:25Z-
Data de disponibilização: dc.date.available2022-02-22T00:26:25Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/jbg.12496-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/199085-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/199085-
Descrição: dc.descriptionThe aim was to conduct a weighted single-step genome-wide association study to detect genomic regions and putative candidate genes related to residual feed intake, dry matter intake, feed efficiency (FE), feed conversion ratio, residual body weight gain, residual intake and weight gain in Nellore cattle. Several protein-coding genes were identified within the genomic regions that explain more than 0.5% of the additive genetic variance for these traits. These genes were associated with insulin, leptin, glucose, protein and lipid metabolisms; energy balance; heat and oxidative stress; bile secretion; satiety; feed behaviour; salivation; digestion; and nutrient absorption. Enrichment analysis revealed functional pathways (p-value <.05) such as neuropeptide signalling (GO:0007218), negative regulation of canonical Wingless/Int-1 (Wnt) signalling (GO:0090090), bitter taste receptor activity (GO:0033038), neuropeptide hormone activity (GO:0005184), bile secretion (bta04976), taste transduction (bta0742) and glucagon signalling pathway (bta04922). The identification of these genes, pathways and their respective functions should contribute to a better understanding of the genetic and physiological mechanisms regulating Nellore FE-related traits.-
Descrição: dc.descriptionDepartment of Animal Science Federal University of Goiás (UFG)-
Descrição: dc.descriptionEmbrapa Rice and Beans Santo Antônio de Goiás-
Descrição: dc.descriptionDepartment of Animal Science São Paulo State University (UNESP)-
Descrição: dc.descriptionCobb-Vantress Inc.-
Descrição: dc.descriptionNational Association of Breeders and Researchers (ANCP)-
Descrição: dc.descriptionDepartment of Veterinary Medicine Faculty of Animal Science and Food Engineering University of Sao Paulo-
Descrição: dc.descriptionBeef Cattle Research Center Animal Science Institute-
Descrição: dc.descriptionEmbrapa Cerrados-
Descrição: dc.descriptionDepartment of Animal Science São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationJournal of Animal Breeding and Genetics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBos indicus-
Palavras-chave: dc.subjectGBLUP-
Palavras-chave: dc.subjectresidual body weight gain-
Palavras-chave: dc.subjectresidual feed intake-
Palavras-chave: dc.subjectweighted single-step-
Título: dc.titleWeighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattle-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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