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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | ETT Spa | - |
Autor(es): dc.contributor | Institute of Biophysics | - |
Autor(es): dc.contributor | University of Eastern Piedmont | - |
Autor(es): dc.contributor | University of Genova | - |
Autor(es): dc.contributor | Italian National Police | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.creator | Alloisio, Susanna | - |
Autor(es): dc.creator | Clericuzio, Marco | - |
Autor(es): dc.creator | Nobile, Mario | - |
Autor(es): dc.creator | Salis, Annalisa | - |
Autor(es): dc.creator | Damonte, Gianluca | - |
Autor(es): dc.creator | Canali, Claudia | - |
Autor(es): dc.creator | Fortuna-Perez, Ana Paula [UNESP] | - |
Autor(es): dc.creator | Cornara, Laura | - |
Autor(es): dc.creator | Burlando, Bruno | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:26:25Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:26:25Z | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2019-12-31 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1080/01480545.2020.1788057 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/199084 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/199084 | - |
Descrição: dc.description | Zornia latifolia is a plant suspected to possess psychoactive properties and marketed as a marijuana substitute under the name ‘maconha brava’. In this study, the effects of fractions obtained from a 2-propanol extract of aerial portions of the plant were determined by multielectrode array (MEA) analyses on cultured networks of rat cortical neurons. Lipophilic (ZL_lipo, mainly containing flavonoid aglycones), and hydrophilic (ZL_hydro, mainly containing flavonoid glycosides) fractions were initially obtained from the raw extract. ZL_lipo significantly inhibited mean firing rate (MFR) and mean bursting rate (MBR) of MEA recordings, while ZL_hydro induced no inhibition. Column chromatography separation of ZL_lipo yielded five fractions (ZL1-ZL5), among which ZL1 induced the strongest MFR and MBR inhibition. NMR and HPLC-MS analyses of ZL1 revealed the prevalence of the common flavonoids genistein (1) and apigenin (2) (in about a 1:1 ratio), and the presence of the rare flavone syzalterin (6,8-dimethylapigenin) (3) as a minor compound. Exposures of MEA to apigenin and genistein standards did not induce the MFR and MBR inhibition observed with ZL1, whereas exposure to syzalterin standard or to a 1:9 mixture syzalterin-genistein induced effects similar to ZL1. These inhibitory effects were comparable to that observed with high-THC hashish, possibly accounting for the plant psychoactive properties. Data indicate that Z. latifolia, currently marketed as a free herbal product, should be subjected to measures of control. In addition, syzalterin showed distinctive pharmacological properties, opening the way to its possible exploitation as a neuroactive drug. | - |
Descrição: dc.description | ETT Spa | - |
Descrição: dc.description | National Research Council (CNR) Institute of Biophysics | - |
Descrição: dc.description | Department of Sciences and Technological Innovation (DISIT) University of Eastern Piedmont | - |
Descrição: dc.description | Center of Excellence for Biomedical Research (CEBR) University of Genova | - |
Descrição: dc.description | Department of Experimental Medicine (DIMES) Section of Biochemistry University of Genova | - |
Descrição: dc.description | Forensic Science Police Service Italian National Police | - |
Descrição: dc.description | Department of Botany São Paulo State University (UNESP) | - |
Descrição: dc.description | Department of Earth Environment and Life Sciences (DISTAV) University of Genova | - |
Descrição: dc.description | Department of Pharmacy (DIFAR) University of Genova | - |
Descrição: dc.description | Department of Botany São Paulo State University (UNESP) | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Drug and Chemical Toxicology | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | Flavonoids | - |
Palavras-chave: dc.subject | hashish | - |
Palavras-chave: dc.subject | multielectrode array | - |
Palavras-chave: dc.subject | psychoactive metabolites | - |
Palavras-chave: dc.subject | smart drugs | - |
Título: dc.title | Cannabis-like activity of Zornia latifolia Sm. detected in vitro on rat cortical neurons: major role of the flavone syzalterin | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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