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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | CQC | - |
Autor(es): dc.creator | Sato, Tabata [UNESP] | - |
Autor(es): dc.creator | Mello, Daphne [UNESP] | - |
Autor(es): dc.creator | Vasconcelos, Luana [UNESP] | - |
Autor(es): dc.creator | Valente, Artur | - |
Autor(es): dc.creator | Borges, Alexandre [UNESP] | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:26:22Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:26:22Z | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2020-06-01 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.3390/ijms21124561 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/199066 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/199066 | - |
Descrição: dc.description | Chitosan-DNA (CS-DNA) and Chitosan-Pectin (CS-P) hydrogels were formulated as a sustained drug delivery carrier for drug delivery. For this, hydrogels were prepared by emulsion technique: mixing aqueous phase of the CS and DNA or P solution with benzyl alcohol using a high-performance dispersing instrument. Green Propolis (GP) was incorporated by imbibition: hydrogels were placed in GP aqueous solution (70 µg/mL) for 2 h. The specimens were freeze-dried and then characterized using different techniques. In vitro cell viability and morphology were also performed using the MG63 cell line. The presence of P was evidenced by the occurrence of a strong band at 1745 cm-1, also occurring in the blend. DNA and CS-DNA showed a strong band at 1650 cm−1, slightly shifted from the chitosan band. The sorption of GP induced a significant modification of the gel surface morphology and some phase separation occurs between chitosan and DNA. Drug release kinetics in water and in saliva follow a two-step mechanism. Significant biocompatibility revealed that these hydrogels were non-toxic and provided acceptable support for cell survival. Thus, the hydrogel complexation of chitosan with DNA and with Pectin provides favorable micro-environment for cell growth and is a viable alternative drug delivery system for Green Propolis. | - |
Descrição: dc.description | Department of Dental Materials and Prosthodontics Institute of Science and Technology Sao Paulo State University UNESP | - |
Descrição: dc.description | Department of Bioscience and Buccal Diagnose Institute of Science and Technology Sao Paulo State University UNESP | - |
Descrição: dc.description | Department of Chemistry University of Coimbra CQC | - |
Descrição: dc.description | Department of Dental Materials and Prosthodontics Institute of Science and Technology Sao Paulo State University UNESP | - |
Descrição: dc.description | Department of Bioscience and Buccal Diagnose Institute of Science and Technology Sao Paulo State University UNESP | - |
Formato: dc.format | 1-15 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | International Journal of Molecular Sciences | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | Chitosan | - |
Palavras-chave: dc.subject | DNA | - |
Palavras-chave: dc.subject | Hydrogel | - |
Palavras-chave: dc.subject | Pectin | - |
Palavras-chave: dc.subject | Propolis | - |
Título: dc.title | Chitosan-based coacervate polymers for propolis encapsulation: Release and cytotoxicity studies | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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