Chitosan-based coacervate polymers for propolis encapsulation: Release and cytotoxicity studies

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorCQC-
Autor(es): dc.creatorSato, Tabata [UNESP]-
Autor(es): dc.creatorMello, Daphne [UNESP]-
Autor(es): dc.creatorVasconcelos, Luana [UNESP]-
Autor(es): dc.creatorValente, Artur-
Autor(es): dc.creatorBorges, Alexandre [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:26:22Z-
Data de disponibilização: dc.date.available2022-02-22T00:26:22Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijms21124561-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/199066-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/199066-
Descrição: dc.descriptionChitosan-DNA (CS-DNA) and Chitosan-Pectin (CS-P) hydrogels were formulated as a sustained drug delivery carrier for drug delivery. For this, hydrogels were prepared by emulsion technique: mixing aqueous phase of the CS and DNA or P solution with benzyl alcohol using a high-performance dispersing instrument. Green Propolis (GP) was incorporated by imbibition: hydrogels were placed in GP aqueous solution (70 µg/mL) for 2 h. The specimens were freeze-dried and then characterized using different techniques. In vitro cell viability and morphology were also performed using the MG63 cell line. The presence of P was evidenced by the occurrence of a strong band at 1745 cm-1, also occurring in the blend. DNA and CS-DNA showed a strong band at 1650 cm−1, slightly shifted from the chitosan band. The sorption of GP induced a significant modification of the gel surface morphology and some phase separation occurs between chitosan and DNA. Drug release kinetics in water and in saliva follow a two-step mechanism. Significant biocompatibility revealed that these hydrogels were non-toxic and provided acceptable support for cell survival. Thus, the hydrogel complexation of chitosan with DNA and with Pectin provides favorable micro-environment for cell growth and is a viable alternative drug delivery system for Green Propolis.-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics Institute of Science and Technology Sao Paulo State University UNESP-
Descrição: dc.descriptionDepartment of Bioscience and Buccal Diagnose Institute of Science and Technology Sao Paulo State University UNESP-
Descrição: dc.descriptionDepartment of Chemistry University of Coimbra CQC-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics Institute of Science and Technology Sao Paulo State University UNESP-
Descrição: dc.descriptionDepartment of Bioscience and Buccal Diagnose Institute of Science and Technology Sao Paulo State University UNESP-
Formato: dc.format1-15-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Molecular Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectChitosan-
Palavras-chave: dc.subjectDNA-
Palavras-chave: dc.subjectHydrogel-
Palavras-chave: dc.subjectPectin-
Palavras-chave: dc.subjectPropolis-
Título: dc.titleChitosan-based coacervate polymers for propolis encapsulation: Release and cytotoxicity studies-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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