The antileishmanial activity of the antarctic brown alga Ascoseira mirabilis Skottsberg

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorClementino, Leandro da Costa [UNESP]-
Autor(es): dc.creatorOda, Fernando Bombarda [UNESP]-
Autor(es): dc.creatorTeixeira, Thaiz Rodrigues-
Autor(es): dc.creatorTavares, Renata Spagolla Napoleão-
Autor(es): dc.creatorColepicolo, Pio-
Autor(es): dc.creatorSantos, André Gonzaga dos [UNESP]-
Autor(es): dc.creatorDebonsi, Hosana Maria-
Autor(es): dc.creatorGraminha, Márcia A. S. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:26:21Z-
Data de disponibilização: dc.date.available2022-02-22T00:26:21Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/14786419.2020.1782403-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/199062-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/199062-
Descrição: dc.descriptionLeishmaniasis is a group of diseases that have limited and high toxic therapeutic options. Herein, we evaluated the antileishmanial potential and cytotoxicity of hexanic extract obtained from the Antarctic brown alga Ascoseira mirabilis using bioguided fractionation against Leishmania amazonensis and murine macrophages, which was fractionated by SPE, yielding seven fractions (F1-F7). The fraction F6 showed good anti-amastigote activity (IC50 = 73.4 ± 0.4 μg mL−1) and low cytotoxicity (CC50 > 100 μg mL−1). Thus, in order to identify the bioactive constituent(s) of F6, the fraction was separated in a semipreparative HPLC, yielding four fractions (F6.1-F6.4). F6.2 was the most bioactive fraction (IC50 = 66.5 ± 4.5 μg mL−1) and GC-MS analyses revealed that the compounds octadecane, propanoic acid, 1-monomyristin and azelaic acid correspond to 61% of its composition. These data show for the first time the antileishmanial potential of the Antarctic alga A. mirabilis.-
Descrição: dc.descriptionChemistry Institute São Paulo State University (UNESP)-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences of Ribeirão Preto São Paulo University (USP)-
Descrição: dc.descriptionChemistry Institute São Paulo University (USP)-
Descrição: dc.descriptionChemistry Institute São Paulo State University (UNESP)-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationNatural Product Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntarctic macroalgae-
Palavras-chave: dc.subjectAscoseiraceae-
Palavras-chave: dc.subjectBrown algae-
Palavras-chave: dc.subjectCutaneous leishmaniasis-
Palavras-chave: dc.subjectGC-MS-
Palavras-chave: dc.subjectNatural products-
Título: dc.titleThe antileishmanial activity of the antarctic brown alga Ascoseira mirabilis Skottsberg-
Tipo de arquivo: dc.typelivro digital-
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