Atenção: Todas as denúncias são sigilosas e sua identidade será preservada.
Os campos nome e e-mail são de preenchimento opcional
Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | University of Edinburgh | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | King Abdulaziz University | - |
Autor(es): dc.creator | Boehm, Ines | - |
Autor(es): dc.creator | Alhindi, Abrar [UNESP] | - |
Autor(es): dc.creator | Leite, Ana S. [UNESP] | - |
Autor(es): dc.creator | Logie, Chandra | - |
Autor(es): dc.creator | Gibbs, Alyssa | - |
Autor(es): dc.creator | Murray, Olivia | - |
Autor(es): dc.creator | Farrukh, Rizwan | - |
Autor(es): dc.creator | Pirie, Robert | - |
Autor(es): dc.creator | Proudfoot, Christopher | - |
Autor(es): dc.creator | Clutton, Richard | - |
Autor(es): dc.creator | Wishart, Thomas M. | - |
Autor(es): dc.creator | Jones, Ross A. | - |
Autor(es): dc.creator | Gillingwater, Thomas H. | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:26:20Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:26:20Z | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2019-12-31 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1111/joa.13260 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/199052 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/199052 | - |
Descrição: dc.description | The neuromuscular junction (NMJ)—a synapse formed between lower motor neuron and skeletal muscle fibre—represents a major focus of both basic neuroscience research and clinical neuroscience research. Although the NMJ is known to play an important role in many neurodegenerative conditions affecting humans, the vast majority of anatomical and physiological data concerning the NMJ come from lower mammalian (e.g. rodent) animal models. However, recent findings have demonstrated major differences between the cellular anatomy and molecular anatomy of human and rodent NMJs. Therefore, we undertook a comparative morphometric analysis of the NMJ across several larger mammalian species in order to generate baseline inter-species anatomical reference data for the NMJ and to identify animal models that better represent the morphology of the human NMJ in vivo. Using a standardized morphometric platform (‘NMJ-morph’), we analysed 5,385 individual NMJs from lower/pelvic limb muscles (EDL, soleus and peronei) of 6 mammalian species (mouse, cat, dog, sheep, pig and human). There was marked heterogeneity of NMJ morphology both within and between species, with no overall relationship found between NMJ morphology and muscle fibre diameter or body size. Mice had the largest NMJs on the smallest muscle fibres; cats had the smallest NMJs on the largest muscle fibres. Of all the species examined, the sheep NMJ had the most closely matched morphology to that found in humans. Taken together, we present a series of comprehensive baseline morphometric data for the mammalian NMJ and suggest that ovine models are likely to best represent the human NMJ in health and disease. | - |
Descrição: dc.description | Edinburgh Medical School: Biomedical Sciences University of Edinburgh | - |
Descrição: dc.description | Euan MacDonald Centre for Motor Neurone Disease Research University of Edinburgh | - |
Descrição: dc.description | School of Medicine UNESP-São Paulo State University | - |
Descrição: dc.description | Faculty of Medicine Department of Anatomy King Abdulaziz University | - |
Descrição: dc.description | The Roslin Institute and R(D)SVS University of Edinburgh | - |
Descrição: dc.description | School of Medicine UNESP-São Paulo State University | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Journal of Anatomy | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | comparative anatomy | - |
Palavras-chave: dc.subject | mammalian | - |
Palavras-chave: dc.subject | neuromuscular junction | - |
Palavras-chave: dc.subject | NMJ-morph | - |
Palavras-chave: dc.subject | synapse | - |
Título: dc.title | Comparative anatomy of the mammalian neuromuscular junction | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
O Portal eduCAPES é oferecido ao usuário, condicionado à aceitação dos termos, condições e avisos contidos aqui e sem modificações. A CAPES poderá modificar o conteúdo ou formato deste site ou acabar com a sua operação ou suas ferramentas a seu critério único e sem aviso prévio. Ao acessar este portal, você, usuário pessoa física ou jurídica, se declara compreender e aceitar as condições aqui estabelecidas, da seguinte forma: