Atenção: Todas as denúncias são sigilosas e sua identidade será preservada.
Os campos nome e e-mail são de preenchimento opcional
Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | The Forsyth Institute | - |
Autor(es): dc.contributor | Guarulhos University | - |
Autor(es): dc.creator | Castro dos Santos, Nidia C. [UNESP] | - |
Autor(es): dc.creator | Andere, Naira M. R. B. [UNESP] | - |
Autor(es): dc.creator | Araujo, Cássia F. [UNESP] | - |
Autor(es): dc.creator | de Marco, Andrea C. [UNESP] | - |
Autor(es): dc.creator | Kantarci, Alpdogan | - |
Autor(es): dc.creator | Van Dyke, Thomas E. | - |
Autor(es): dc.creator | Santamaria, Mauro P. [UNESP] | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:26:20Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:26:20Z | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2019-12-31 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1002/JPER.19-0613 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/199050 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/199050 | - |
Descrição: dc.description | Background: Supplementation with omega-3 polyunsaturated fatty acids (ω-3 PUFA) and low-dose aspirin (ASA) have been proposed as a host modulation regimen to control chronic inflammatory diseases. The aim of this study was to investigate the clinical and immunological impact of orally administered ω-3 PUFA and ASA as adjuncts to periodontal debridement for the treatment of periodontitis in patients type 2 diabetes. Methods: Seventy-five patients (n = 25/group) were randomly assigned to receive placebo and periodontal debridement (CG), ω-3 PUFA + ASA (3 g of fish oil/d + 100 mg ASA/d for 2 months) after periodontal debridement (test group [TG]1), or ω-3 PUFA + ASA (3 g of fish oil/d + 100 mg ASA/d for 2 months) before periodontal debridement (TG2). Periodontal parameters and GCF were collected at baseline (t0), 3 months after periodontal debridement and ω-3 PUFA + ASA or placebo for TG1 and CG (t1), after ω-3 PUFA + ASA (before periodontal debridement) for TG2 (t1), and 6 months after periodontal debridement (all groups) (t2). GCF was analyzed for cytokine levels by multiplex ELISA. Results: Ten patients (40%) in TG1 and nine patients (36%) in TG2 achieved the clinical endpoint for treatment (less than or equal to four sites with probing depth ≥ 5 mm), as opposed to four (16%) in CG. There was clinical attachment gain in moderate and deep pockets for TG1. IFN-γ and interleukin (IL)-8 levels decreased over time for both test groups. IL-6 levels were lower for TG1. HbA1c levels reduced for TG1. Conclusion: Adjunctive ω-3 and ASA after periodontal debridement provides clinical and immunological benefits to the treatment of periodontitis in patients with type 2 diabetes. | - |
Descrição: dc.description | Division of Periodontics Unesp – São Paulo State University Institute of Science and Technology | - |
Descrição: dc.description | Center for Clinical and Translational Research The Forsyth Institute | - |
Descrição: dc.description | Dental Research Division Guarulhos University | - |
Descrição: dc.description | Division of Periodontics Unesp – São Paulo State University Institute of Science and Technology | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Journal of Periodontology | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | aspirin | - |
Palavras-chave: dc.subject | diabetes | - |
Palavras-chave: dc.subject | immunomodulation | - |
Palavras-chave: dc.subject | inflammation | - |
Palavras-chave: dc.subject | omega-3 fatty acids | - |
Palavras-chave: dc.subject | periodontitis | - |
Título: dc.title | Omega-3 PUFA and aspirin as adjuncts to periodontal debridement in patients with periodontitis and type 2 diabetes mellitus: Randomized clinical trial | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
O Portal eduCAPES é oferecido ao usuário, condicionado à aceitação dos termos, condições e avisos contidos aqui e sem modificações. A CAPES poderá modificar o conteúdo ou formato deste site ou acabar com a sua operação ou suas ferramentas a seu critério único e sem aviso prévio. Ao acessar este portal, você, usuário pessoa física ou jurídica, se declara compreender e aceitar as condições aqui estabelecidas, da seguinte forma: