Separation and purification of curcumin using novel aqueous two-phase micellar systems composed of amphiphilic copolymer and cholinium ionic liquids

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversity of Minho-
Autor(es): dc.contributorRua Sílvio Lima-
Autor(es): dc.creatorKurnik, Isabelle S. [UNESP]-
Autor(es): dc.creatorNoronha, Mariana A.-
Autor(es): dc.creatorCâmara, Mayra C.C.-
Autor(es): dc.creatorMazzola, Priscila G.-
Autor(es): dc.creatorVicente, António A.-
Autor(es): dc.creatorPereira, Jorge F.B. [UNESP]-
Autor(es): dc.creatorLopes, André M.-
Data de aceite: dc.date.accessioned2022-02-22T00:26:14Z-
Data de disponibilização: dc.date.available2022-02-22T00:26:14Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.seppur.2020.117262-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/199026-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/199026-
Descrição: dc.descriptionNovel aqueous two-phase micellar systems (ATPMS) composed of Pluronic F68, a triblock amphiphilic copolymer, and cholinium-based ionic liquids (ILs) were formulated and applied for separation/purification of curcumin (CCM). CCM stability in the presence of ATPMS components was also evaluated. CCM is stable up to 24 h in copolymer (1.0 – 10.0 wt%) and ILs (0.1 – 3.0 M) aqueous solutions. Very mild phase separation conditions (close to room temperature) were achieved by adding cholinium ILs to the Pluronic F68 + McIlvaine buffer at pH 6.0 solution. The decrease of cloud-point temperature is dependent on the relative hydrophobicity of IL anion, [Hex]− > [But]− > [Pro]− > [Ac]− > Cl−. ATPMS composed of more hydrophobic ILs ([Ch][Hex] > [Ch][But] > [Ch][Pro]) are most efficient in the partition of commercial CCM into polymeric micelles (PMs)-rich phase. The best ATPMS (0.70 M [Ch][But] and 0.60 M [Ch][Hex]-based ATPMS) were then used to purify CCM from a crude extract of Curcuma longa L. Both systems were very selective to separate CCM from protein-based contaminants (selectivity values ≥ 25; purification yields ≥ 12-fold). Pluronic F68-based ATPMS are promising for selective separation of hydrophobic biomolecules by using cholinium-based ILs as adjuvants to adjust phase separation temperatures and biomolecules’ partition.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Engineering Bioprocesses and Biotechnology School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionFaculty of Pharmaceutical Sciences University of Campinas-
Descrição: dc.descriptionCentre of Biological Engineering (CEB) University of Minho, Campus de Gualtar-
Descrição: dc.descriptionUniv Coimbra CIEPQPF Department of Chemical Engineering Rua Sílvio Lima, Pólo II – Pinhal de Marrocos-
Descrição: dc.descriptionDepartment of Engineering Bioprocesses and Biotechnology School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 2014/16424-7-
Descrição: dc.descriptionFAPESP: 2017/10789-1-
Descrição: dc.descriptionFAPESP: 2018/05111-9-
Descrição: dc.descriptionFAPESP: 2018/10799-0-
Descrição: dc.descriptionFAPESP: 2019/05624-9-
Descrição: dc.descriptionFAPESP: 2019/08549-8-
Idioma: dc.languageen-
Relação: dc.relationSeparation and Purification Technology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectaqueous two-phase micellar systems (ATPMS)-
Palavras-chave: dc.subjectcurcumin (CCM)-
Palavras-chave: dc.subjectionic liquids (ILs)-
Palavras-chave: dc.subjectPluronic F68-
Palavras-chave: dc.subjectpolymeric micelles (PMs)-
Palavras-chave: dc.subjectseparation-
Título: dc.titleSeparation and purification of curcumin using novel aqueous two-phase micellar systems composed of amphiphilic copolymer and cholinium ionic liquids-
Tipo de arquivo: dc.typelivro digital-
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