Simultaneous determination of paracetamol and caffeine in pharmaceutical formulations and synthetic urine using cork-modified graphite electrodes

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Federal do Rio Grande do Norte-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorMonteiro, M. K.S.-
Autor(es): dc.creatorSantos, E. C.M.M.-
Autor(es): dc.creatorSilva, D. R.-
Autor(es): dc.creatorMartínez-Huitle, C. A. [UNESP]-
Autor(es): dc.creatordos Santos, E. V. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:26:08Z-
Data de disponibilização: dc.date.available2022-02-22T00:26:08Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s10008-020-04722-y-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/198999-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/198999-
Descrição: dc.descriptionCork-modified graphite electrodes were used to develop a simple and selective sensor for the simultaneous determination of paracetamol (PAR) and caffeine (CAF). The sensor was fabricated on raw cork (RAC) and regranulated cork (RGC). When modified with RAC, graphite (GrRAC) displayed an improvement in voltammetric responses for PAR and CAF compared to the sensor modified with RGC (GrRGC). By applying differential pulse voltammetry (DPV) in an acidic medium with the GrRAC sensor, it was possible to simultaneously determine the concentrations of PAR and CAR (ranging from 0 to 50 μM), with limits of detection of 8.36 and 12.25 μM, respectively. The fabricated electrochemical sensor was able to individually and simultaneously detect PAR and CAF in different samples, confirming that the proposed sensor is a practical and effective tool for determining these pharmaceuticals in dosage forms and synthetic urine. Moreover, GrRAC and GrRGC possessed several advantages compared with current methods of detection, including very low detection limits, high sensitivity, long-term stability, and excellent reproducibility.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionLaboratório de Eletroquímica Ambiental e Aplicada Instituto de Química Universidade Federal do Rio Grande do Norte-
Descrição: dc.descriptionNational Institute for Alternative Technologies of Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCTDATREM) Institute of Chemistry Unesp, P.O. Box 355-
Descrição: dc.descriptionNational Institute for Alternative Technologies of Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCTDATREM) Institute of Chemistry Unesp, P.O. Box 355-
Descrição: dc.descriptionFAPESP: 2014/50945-4-
Descrição: dc.descriptionCNPq: 306323/2018-4-
Descrição: dc.descriptionCNPq: 430121/2016-4-
Descrição: dc.descriptionCNPq: 465571/2014-0-
Formato: dc.format1789-1800-
Idioma: dc.languageen-
Relação: dc.relationJournal of Solid State Electrochemistry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCaffeine-
Palavras-chave: dc.subjectCork-
Palavras-chave: dc.subjectElectrochemical sensor-
Palavras-chave: dc.subjectParacetamol-
Título: dc.titleSimultaneous determination of paracetamol and caffeine in pharmaceutical formulations and synthetic urine using cork-modified graphite electrodes-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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