Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer

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Autor(es): dc.contributorUniversity of Cambridge-
Autor(es): dc.contributorUniversity of Gothenburg-
Autor(es): dc.contributorNewcastle University-
Autor(es): dc.contributorInternational Training Center-
Autor(es): dc.contributorAnimal Management in Rural and Remote Indigenous Communities (AMRRIC)-
Autor(es): dc.contributorWorld Vets-
Autor(es): dc.contributorHopkins Belize Humane Society-
Autor(es): dc.contributorStichting Dierenbescherming Suriname-
Autor(es): dc.contributorGovernment of Sikkim-
Autor(es): dc.contributorUniversity of Chile-
Autor(es): dc.contributorUniversity of Panamá-
Autor(es): dc.contributorSt. George’s University-
Autor(es): dc.contributorThe Nakuru District Veterinary Scheme Ltd-
Autor(es): dc.contributorAnimal Medical Centre-
Autor(es): dc.contributorUC Davis School of Veterinary Medicine-
Autor(es): dc.contributorSão José do Rio Preto-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorLadybrand Animal Clinic-
Autor(es): dc.contributorVeterinary Clinic Sr. Dog’s-
Autor(es): dc.contributorWorld Vets Latin America Veterinary Training Center-
Autor(es): dc.contributorNational Veterinary Research Institute-
Autor(es): dc.contributorAnimal Clinic-
Autor(es): dc.contributorIntermunicipal Stray Animals Care Centre (DIKEPAZ)-
Autor(es): dc.contributorAnimal Protection Society of Samoa-
Autor(es): dc.contributorUniversity of Zulia-
Autor(es): dc.contributorVeterinary Clinic BIOCONTROL-
Autor(es): dc.contributorUniversity of Thessaly-
Autor(es): dc.contributorHospital Veterinário Berna-
Autor(es): dc.contributorUniversidade Vila Velha-
Autor(es): dc.contributorVeterinary Clinic Zoovetservis-
Autor(es): dc.contributorÉcole Inter-états des Sciences et Médecine Vétérinaires de Dakar-
Autor(es): dc.contributorUtrecht University-
Autor(es): dc.contributorVetexpert Veterinary Group-
Autor(es): dc.contributorLopez Quintana Veterinary Clinic-
Autor(es): dc.contributorSaint Gilles les Bains-
Autor(es): dc.contributorUniversity of Messina-
Autor(es): dc.contributorUniversidad Autónoma del Estado de México-
Autor(es): dc.contributorUniversidad de las Américas-
Autor(es): dc.contributorVeterinary Council of Tanzania-
Autor(es): dc.contributorTouray & Meyer Vet Clinic-
Autor(es): dc.contributorHillside Animal Hospital-
Autor(es): dc.contributorThe Kampala Veterinary Surgery-
Autor(es): dc.contributorAsavet Veterinary Charities-
Autor(es): dc.contributorVets Beyond Borders-
Autor(es): dc.contributorAutonomous University of Yucatan-
Autor(es): dc.contributorUniversidad de Caldas-
Autor(es): dc.contributorUniversity of Lisbon-
Autor(es): dc.contributorFour Paws International-
Autor(es): dc.contributorHelp in Suffering-
Autor(es): dc.contributorVeterinary Clinic Dr José Rojas-
Autor(es): dc.contributorEngineering and Management Sciences-
Autor(es): dc.contributorCorozal Veterinary Clinic-
Autor(es): dc.contributorVeterinary Clinic Vetmaster-
Autor(es): dc.contributorState Hospital of Veterinary Medicine-
Autor(es): dc.contributorJomo Kenyatta University of Agriculture and Technology-
Autor(es): dc.contributorUniversity of Melbourne-
Autor(es): dc.contributorAnimal Anti Cruelty League-
Autor(es): dc.contributorFaculty of Veterinary Medicine Bucharest-
Autor(es): dc.contributorAnkara University-
Autor(es): dc.contributorNational University of Asuncion-
Autor(es): dc.contributorLilongwe Society for Protection and Care of Animals (LSPCA)-
Autor(es): dc.contributorVeterinary clinic Canine Heart-
Autor(es): dc.creatorStrakova, Andrea-
Autor(es): dc.creatorNicholls, Thomas J.-
Autor(es): dc.creatorBaez-Ortega, Adrian-
Autor(es): dc.creatorNí Leathlobhair, Máire-
Autor(es): dc.creatorSampson, Alexander T.-
Autor(es): dc.creatorHughes, Katherine-
Autor(es): dc.creatorBolton, Isobelle A. G.-
Autor(es): dc.creatorGori, Kevin-
Autor(es): dc.creatorWang, Jinhong-
Autor(es): dc.creatorAirikkala-Otter, Ilona-
Autor(es): dc.creatorAllen, Janice L.-
Autor(es): dc.creatorAllum, Karen M.-
Autor(es): dc.creatorArnold, Clara L.-
Autor(es): dc.creatorBansse-Issa, Leontine-
Autor(es): dc.creatorBhutia, Thinlay N.-
Autor(es): dc.creatorBisson, Jocelyn L.-
Autor(es): dc.creatorBlank, Kelli-
Autor(es): dc.creatorBriceño, Cristóbal-
Autor(es): dc.creatorCastillo Domracheva, Artemio-
Autor(es): dc.creatorCorrigan, Anne M.-
Autor(es): dc.creatorCran, Hugh R.-
Autor(es): dc.creatorCrawford, Jane T.-
Autor(es): dc.creatorCutter, Stephen M.-
Autor(es): dc.creatorDavis, Eric-
Autor(es): dc.creatorde Castro, Karina F.-
Autor(es): dc.creatorDe Nardi, Andrigo B. [UNESP]-
Autor(es): dc.creatorde Vos, Anna P.-
Autor(es): dc.creatorDelgadillo Keenan, Laura-
Autor(es): dc.creatorDonelan, Edward M.-
Autor(es): dc.creatorEspinoza Huerta, Adela R.-
Autor(es): dc.creatorFaramade, Ibikunle A.-
Autor(es): dc.creatorFazil, Mohammed-
Autor(es): dc.creatorFotopoulou, Eleni-
Autor(es): dc.creatorFruean, Skye N.-
Autor(es): dc.creatorGallardo-Arrieta, Fanny-
Autor(es): dc.creatorGlebova, Olga-
Autor(es): dc.creatorGouletsou, Pagona G.-
Autor(es): dc.creatorHäfelin Manrique, Rodrigo F.-
Autor(es): dc.creatorHenriques, Joaquim J. G. P.-
Autor(es): dc.creatorHorta, Rodrigo S.-
Autor(es): dc.creatorIgnatenko, Natalia-
Autor(es): dc.creatorKane, Yaghouba-
Autor(es): dc.creatorKing, Cathy-
Autor(es): dc.creatorKoenig, Debbie-
Autor(es): dc.creatorKrupa, Ada-
Autor(es): dc.creatorKruzeniski, Steven J.-
Autor(es): dc.creatorLanza-Perea, Marta-
Autor(es): dc.creatorLazyan, Mihran-
Autor(es): dc.creatorLopez Quintana, Adriana M.-
Autor(es): dc.creatorLosfelt, Thibault-
Autor(es): dc.creatorMarino, Gabriele-
Autor(es): dc.creatorMartínez Castañeda, Simón-
Autor(es): dc.creatorMartínez-López, Mayra F.-
Autor(es): dc.creatorMasuruli, Bedan M.-
Autor(es): dc.creatorMeyer, Michael-
Autor(es): dc.creatorMigneco, Edward J.-
Autor(es): dc.creatorNakanwagi, Berna-
Autor(es): dc.creatorNeal, Karter B.-
Autor(es): dc.creatorNeunzig, Winifred-
Autor(es): dc.creatorNixon, Sally J.-
Autor(es): dc.creatorOrtega-Pacheco, Antonio-
Autor(es): dc.creatorPedraza-Ordoñez, Francisco-
Autor(es): dc.creatorPeleteiro, Maria C.-
Autor(es): dc.creatorPolak, Katherine-
Autor(es): dc.creatorPye, Ruth J.-
Autor(es): dc.creatorRamirez-Ante, Juan C.-
Autor(es): dc.creatorReece, John F.-
Autor(es): dc.creatorRojas Gutierrez, Jose-
Autor(es): dc.creatorSadia, Haleema-
Autor(es): dc.creatorSchmeling, Sheila K.-
Autor(es): dc.creatorShamanova, Olga-
Autor(es): dc.creatorSherlock, Alan G.-
Autor(es): dc.creatorSteenland-Smit, Audrey E.-
Autor(es): dc.creatorSvitich, Alla-
Autor(es): dc.creatorTapia Martínez, Lester J.-
Autor(es): dc.creatorThoya Ngoka, Ismail-
Autor(es): dc.creatorTorres, Cristian G.-
Autor(es): dc.creatorTudor, Elizabeth M.-
Autor(es): dc.creatorvan der Wel, Mirjam G.-
Autor(es): dc.creatorVițălaru, Bogdan A.-
Autor(es): dc.creatorVural, Sevil A.-
Autor(es): dc.creatorWalkinton, Oliver-
Autor(es): dc.creatorWehrle-Martinez, Alvaro S.-
Autor(es): dc.creatorWiddowson, Sophie A. E.-
Autor(es): dc.creatorZvarich, Irina-
Autor(es): dc.creatorChinnery, Patrick F.-
Autor(es): dc.creatorFalkenberg, Maria-
Autor(es): dc.creatorGustafsson, Claes M.-
Autor(es): dc.creatorMurchison, Elizabeth P.-
Data de aceite: dc.date.accessioned2022-02-22T00:26:07Z-
Data de disponibilização: dc.date.available2022-02-22T00:26:07Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41467-020-16765-w-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/198994-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/198994-
Descrição: dc.descriptionAutonomous replication and segregation of mitochondrial DNA (mtDNA) creates the potential for evolutionary conflict driven by emergence of haplotypes under positive selection for ‘selfish’ traits, such as replicative advantage. However, few cases of this phenomenon arising within natural populations have been described. Here, we survey the frequency of mtDNA horizontal transfer within the canine transmissible venereal tumour (CTVT), a contagious cancer clone that occasionally acquires mtDNA from its hosts. Remarkably, one canine mtDNA haplotype, A1d1a, has repeatedly and recently colonised CTVT cells, recurrently replacing incumbent CTVT haplotypes. An A1d1a control region polymorphism predicted to influence transcription is fixed in the products of an A1d1a recombination event and occurs somatically on other CTVT mtDNA backgrounds. We present a model whereby ‘selfish’ positive selection acting on a regulatory variant drives repeated fixation of A1d1a within CTVT cells.-
Descrição: dc.descriptionTransmissible Cancer Group Department of Veterinary Medicine University of Cambridge-
Descrição: dc.descriptionDepartment of Medical Biochemistry and Cell Biology University of Gothenburg-
Descrição: dc.descriptionWellcome Centre for Mitochondrial Research Newcastle University-
Descrição: dc.descriptionDepartment of Veterinary Medicine University of Cambridge-
Descrição: dc.descriptionWorldwide Veterinary Service International Training Center-
Descrição: dc.descriptionAnimal Management in Rural and Remote Indigenous Communities (AMRRIC)-
Descrição: dc.descriptionWorld Vets-
Descrição: dc.descriptionHopkins Belize Humane Society-
Descrição: dc.descriptionAnimal Shelter Stichting Dierenbescherming Suriname-
Descrição: dc.descriptionSikkim Anti-Rabies and Animal Health Programme Department of Animal Husbandry Livestock Fisheries and Veterinary Services Government of Sikkim-
Descrição: dc.descriptionConserLab Animal Preventive Medicine Department Faculty of Animal and Veterinary Sciences University of Chile-
Descrição: dc.descriptionCorozal Veterinary Hospital University of Panamá-
Descrição: dc.descriptionSt. George’s University-
Descrição: dc.descriptionThe Nakuru District Veterinary Scheme Ltd-
Descrição: dc.descriptionAnimal Medical Centre-
Descrição: dc.descriptionInternational Animal Welfare Training Institute UC Davis School of Veterinary Medicine-
Descrição: dc.descriptionCentro Universitário de Rio Preto (UNIRP) São José do Rio Preto-
Descrição: dc.descriptionSchool of Agricultural and Veterinary Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionLadybrand Animal Clinic-
Descrição: dc.descriptionVeterinary Clinic Sr. Dog’s-
Descrição: dc.descriptionWorld Vets Latin America Veterinary Training Center-
Descrição: dc.descriptionNational Veterinary Research Institute-
Descrição: dc.descriptionAnimal Clinic-
Descrição: dc.descriptionIntermunicipal Stray Animals Care Centre (DIKEPAZ)-
Descrição: dc.descriptionAnimal Protection Society of Samoa-
Descrição: dc.descriptionFaculty of Veterinary Science University of Zulia-
Descrição: dc.descriptionVeterinary Clinic BIOCONTROL-
Descrição: dc.descriptionFaculty of Veterinary Medicine School of Health Sciences University of Thessaly-
Descrição: dc.descriptionVeterinary Clinic El Roble Animal Healthcare Network Faculty of Animal and Veterinary Sciences University of Chile-
Descrição: dc.descriptionOnevetGroup Hospital Veterinário Berna-
Descrição: dc.descriptionUniversidade Vila Velha-
Descrição: dc.descriptionVeterinary Clinic Zoovetservis-
Descrição: dc.descriptionÉcole Inter-états des Sciences et Médecine Vétérinaires de Dakar-
Descrição: dc.descriptionDepartment of Small Animal Medicine Faculty of Veterinary Medicine Utrecht University-
Descrição: dc.descriptionVetexpert Veterinary Group-
Descrição: dc.descriptionLopez Quintana Veterinary Clinic-
Descrição: dc.descriptionClinique Veterinaire de Grand Fond Saint Gilles les Bains-
Descrição: dc.descriptionDepartment of Veterinary Sciences University of Messina-
Descrição: dc.descriptionFacultad de Medicina Veterinaria y Zootecnia Universidad Autónoma del Estado de México-
Descrição: dc.descriptionSchool of Veterinary Medicine Universidad de las Américas-
Descrição: dc.descriptionVeterinary Council of Tanzania-
Descrição: dc.descriptionTouray & Meyer Vet Clinic-
Descrição: dc.descriptionHillside Animal Hospital-
Descrição: dc.descriptionThe Kampala Veterinary Surgery-
Descrição: dc.descriptionAsavet Veterinary Charities-
Descrição: dc.descriptionVets Beyond Borders-
Descrição: dc.descriptionFaculty of Veterinary Medicine Autonomous University of Yucatan-
Descrição: dc.descriptionLaboratorio de Patología Veterinaria Universidad de Caldas-
Descrição: dc.descriptionCentre for Interdisciplinary Research in Animal Health (CIISA) Faculty of Veterinary Medicine University of Lisbon-
Descrição: dc.descriptionFour Paws International-
Descrição: dc.descriptionHelp in Suffering-
Descrição: dc.descriptionVeterinary Clinic Dr José Rojas-
Descrição: dc.descriptionDepartment of Biotechnology Balochistan University of Information Technology Engineering and Management Sciences-
Descrição: dc.descriptionCorozal Veterinary Clinic-
Descrição: dc.descriptionVeterinary Clinic Vetmaster-
Descrição: dc.descriptionState Hospital of Veterinary Medicine-
Descrição: dc.descriptionJomo Kenyatta University of Agriculture and Technology-
Descrição: dc.descriptionLaboratory of Biomedicine and Regenerative Medicine Department of Clinical Sciences Faculty of Animal and Veterinary Sciences University of Chile-
Descrição: dc.descriptionFaculty of Veterinary and Agricultural Sciences University of Melbourne-
Descrição: dc.descriptionAnimal Anti Cruelty League-
Descrição: dc.descriptionClinical Sciences Department Faculty of Veterinary Medicine Bucharest-
Descrição: dc.descriptionDepartment of Pathology Faculty of Veterinary Medicine Ankara University-
Descrição: dc.descriptionFaculty of Veterinary Sciences National University of Asuncion-
Descrição: dc.descriptionLilongwe Society for Protection and Care of Animals (LSPCA)-
Descrição: dc.descriptionVeterinary clinic Canine Heart-
Descrição: dc.descriptionMRC-Mitochondrial Biology Unit & Department of Clinical Neurosciences University of Cambridge-
Descrição: dc.descriptionSchool of Agricultural and Veterinary Sciences São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationNature Communications-
???dc.source???: dc.sourceScopus-
Título: dc.titleRecurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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