Rock protein as cardiac hypertrophy modulator in obesity and physical exercise

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorAnaruma, Chadi Pellegrini [UNESP]-
Autor(es): dc.creatorPereira, Rodrigo Martins-
Autor(es): dc.creatorCristina da Cruz Rodrigues, Kellen-
Autor(es): dc.creatorRamos da Silva, Adelino Sanchez-
Autor(es): dc.creatorCintra, Dennys Esper-
Autor(es): dc.creatorRopelle, Eduardo Rochete-
Autor(es): dc.creatorPauli, José Rodrigo-
Autor(es): dc.creatorPereira de Moura, Leandro [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:25:57Z-
Data de disponibilização: dc.date.available2022-02-22T00:25:57Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.lfs.2019.116955-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/198934-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/198934-
Descrição: dc.descriptionObesity and cardiovascular diseases are worldwide public health issues. In this review, we discussed the participation of ROCK protein in cardiac hypertrophy, mainly through the modulation of leptin and insulin signaling pathways. Leptin plays a role in cardiovascular disease development and, through the Rho-associated protein kinase (ROCK), promotes cardiac hypertrophy. ROCK protein, is regulated by small Rho-GTPases and has two isoforms with high homology. ROCK is able to activate the MAP kinase (MAPK) pathway and modulate insulin signaling in the heart, participating in cardiac hypertrophy development of concentric and eccentric left ventricle growth. Although different types of stimulus can lead to morphologically antagonistic heart growth, physical exercise promotes improvements in hemodynamic function, emerging as a promising non-pharmacological tool to improve overall health. Leptin can activate ROCK in a pathological way, increasing MAPK activity and decreasing insulin signaling via insulin receptor substrate 1 (IRS1) serine 307 residue phosphorylation, phosphatase and tensin homolog, and protein kinase Cβ2. In turn, physical exercise decreases leptin levels and positively modulates insulin signaling as well as increases ROCK-dependent IRS1 (Ser632/635) phosphorylation, improving phosphatidylinositol 3-kinase/protein kinase B axis and promoting physiologic heart growth. Currently, there is a lack of studies about differences in ROCK isoforms, especially during exercise and/or obesity. However, the understanding of its biological function and the complex mechanism underlying the distinct types of cardiac hypertrophy development can be a useful tool in the improvement and treatment of cardiovascular outcomes.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Physical Education Institute of Biosciences - São Paulo State University (UNESP)-
Descrição: dc.descriptionExercise Cell Biology Lab (ECEBIL) School of Applied Science - University of Campinas-
Descrição: dc.descriptionCEPECE - Center of Research in Sport Sciences School of Applied Sciences - University of Campinas (UNICAMP)-
Descrição: dc.descriptionSchool of Physical Education and Sport of Ribeirão Preto - University of São Paulo (USP)-
Descrição: dc.descriptionLaboratory of Nutritional Genomics (LabGeN) School of Applied Science - University of Campinas-
Descrição: dc.descriptionLaboratory of Molecular Biology of Exercise (LaBMEx) School of Applied Science - University of Campinas-
Descrição: dc.descriptionDepartment of Physical Education Institute of Biosciences - São Paulo State University (UNESP)-
Descrição: dc.descriptionFAPESP: 2015/07199-2-
Descrição: dc.descriptionFAPESP: 2016/14388-9-
Descrição: dc.descriptionFAPESP: 2018/15461-7-
Idioma: dc.languageen-
Relação: dc.relationLife Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCardiac hypertrophy-
Palavras-chave: dc.subjectLeptin-
Palavras-chave: dc.subjectObesity-
Palavras-chave: dc.subjectPhysical exercise-
Palavras-chave: dc.subjectROCK-
Título: dc.titleRock protein as cardiac hypertrophy modulator in obesity and physical exercise-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.