Blood flow restriction impairs the inflammatory adaptations of strength training in overweight men: A clinical randomized trial

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of Health Sciences of Porto Alegre-
Autor(es): dc.contributorMethodist University Center IPA-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorDa Silva, Igor Martins-
Autor(es): dc.creatorSantos, Maeli Andressa-
Autor(es): dc.creatorGalvão, Simone Lunelli-
Autor(es): dc.creatorDorneles, Gilson P.-
Autor(es): dc.creatorLira, Fabio Santos [UNESP]-
Autor(es): dc.creatorRomão, Pedro R. T.-
Autor(es): dc.creatorPeres, Alessandra-
Data de aceite: dc.date.accessioned2022-02-22T00:25:53Z-
Data de disponibilização: dc.date.available2022-02-22T00:25:53Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1139/apnm-2019-0700-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/198915-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/198915-
Descrição: dc.descriptionThe aim of this study was to evaluate the impact of high-intensity strength training (ST) or low-intensity strength training with bloodflowrestriction (ST-BFR) on monocyte subsets, the expression of C-C chemokine receptor 5 (CCR5), and CD16 on monocytes, and tumor necrosis factor alpha (TNF-α) production of overweight men. Thirty overweight men were randomly assigned to conventional ST or ST-BFR. Both groups performed exercises of knee extension and biceps curl with equal volume (3 sessions/week) over 8 weeks, and the peripheral frequency of monocytes (CD14+CD16−, classical monocytes; CD14+CD16+, intermediate monocytes; CD14−CD16+, nonclassical monocytes), the mean fluorescence intensity (MFI) of CCR5 and CD16 on CD14+ monocytes; and the production of TNF-α by lipopolysaccharide (LPS)-stimulated cells were quantified. Eight weeks of ST increased the frequency of CD14+CD16− monocytes (p = 0.04) and reduced the percentage of CD14−CD16+ (p = 0.02) and the production of TNF-α by LPS-stimulated cells (p = 0.03). The MFI of CD16 on CD14+ monocytes decreased after the ST intervention (p = 0.02). No difference in monocyte subsets, CCR5 or CD16 expression, and TNF-α production were identified after ST-BFR intervention (p > 0.05). The adoption of ST promotes anti-inflammatory effects on monocyte subsets of overweight men, but this effect was lost when BFR was adopted. Novelty • High-intensity strength training reduces the production of TNF-α and the peripheral frequency of CD16+ monocytes in overweight men. • Blood flow restriction method blunts the strength training adaptations on monocyte subsets and pro-inflammatory TNF-α production in overweight men.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionLaboratory of Cellular and Molecular Immunology Department of Health Basic Sciences Federal University of Health Sciences of Porto Alegre-
Descrição: dc.descriptionResearch Center Methodist University Center IPA-
Descrição: dc.descriptionExercise and Immunometabolism Research Group Department of Physical Education São Paulo State University (UNESP)-
Descrição: dc.descriptionExercise and Immunometabolism Research Group Department of Physical Education São Paulo State University (UNESP)-
Descrição: dc.descriptionCAPES: CAPES-PNPD-23038007200/11-08-
Formato: dc.format659-666-
Idioma: dc.languageen-
Relação: dc.relationApplied Physiology, Nutrition and Metabolism-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCytokines-
Palavras-chave: dc.subjectExercise immunology-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectMonocytes-
Palavras-chave: dc.subjectOverweight-
Palavras-chave: dc.subjectStrength exercise-
Palavras-chave: dc.subjectTumor necrosis factor-alpha-
Palavras-chave: dc.subjectVascular occlusion-
Título: dc.titleBlood flow restriction impairs the inflammatory adaptations of strength training in overweight men: A clinical randomized trial-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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