Bruxism throughout the lifespan and variants in MMP2, MMP9 and COMT

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorSchool of Dental Medicine-
Autor(es): dc.contributorPositivo University-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorVieira, Alexandre R.-
Autor(es): dc.creatorScariot, Rafaela-
Autor(es): dc.creatorGerber, Jennifer T.-
Autor(es): dc.creatorArid, Juliana-
Autor(es): dc.creatorKüchler, Erika C.-
Autor(es): dc.creatorSebastiani, Aline M.-
Autor(es): dc.creatorPalinkas, Marcelo-
Autor(es): dc.creatorDíaz-Serrano, Kranya V.-
Autor(es): dc.creatorTorres, Carolina P.-
Autor(es): dc.creatorRegalo, Simone C.H.-
Autor(es): dc.creatorNelson-Filho, Paulo-
Autor(es): dc.creatorBussaneli, Diego G. [UNESP]-
Autor(es): dc.creatorDeeley, Kathleen-
Autor(es): dc.creatorModesto, Adriana-
Data de aceite: dc.date.accessioned2022-02-22T00:25:53Z-
Data de disponibilização: dc.date.available2022-02-22T00:25:53Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/jpm10020044-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/198913-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/198913-
Descrição: dc.descriptionBruxism is a masticatory muscle activity characterized by grinding of the teeth and clenching of the jaw that causes tooth wear and breakage, temporomandibular joint disorders, muscle pain, and headache. Bruxism occurs in both adults and children. Clinical characteristics and habits were evaluated in an adult sample. Moreover, we used DNA samples from 349 adults and 151 children to determine the presence of association with specific genes. Genomic DNA was obtained from saliva. The markers rs2241145 and rs243832 (metalloproteinase 2 (MMP2)), rs13925 and rs2236416 (metalloproteinase 9 (MMP9)), and rs6269 (cathecol-o-methyltransferase (COMT)) were genotyped. Data were submitted to statistical analysis with a significance level of 0.05. In adults, in univariate logistic regression, presence of caries, attrition, and use of alcohol were increased in bruxism individuals (p < 0.05). In addition, in adults, there was an association between bruxism and MMP9 (rs13925, p = 0.0001) and bruxism and COMT (rs6269, p = 0.003). In children, a borderline association was observed for MMP9 (rs2236416, p = 0.08). When we performed multivariate logistic regression analyses in adults, the same clinical characteristics remained associated with bruxism, and orthodontic treatment was also associated, besides rs13925, in the AG genotype (p = 0.015, ORa: 3.40 (1.27–9.07)). For the first time, we provide statistical evidence that these genes are associate with bruxism.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionUniversity of Pittsburgh-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Oral Biology University of Pittsburgh School of Dental Medicine, 412 Salk Pavilion, 335 Sutherland Drive-
Descrição: dc.descriptionDepartment of Pediatric Dentistry University of Pittsburgh School of Dental Medicine-
Descrição: dc.descriptionDepartment of Oral and Maxillofacial Surgery Positivo University-
Descrição: dc.descriptionDepartment of Pediatric Dentistry USP-
Descrição: dc.descriptionDepartment of Morphology Physiology and Basic Pathology USP-
Descrição: dc.descriptionDepartment of Pediatric Dentistry UNESP-
Descrição: dc.descriptionDepartment of Pediatric Dentistry UNESP-
Descrição: dc.descriptionFAPESP: 2015/06866-5-
Idioma: dc.languageen-
Relação: dc.relationJournal of Personalized Medicine-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBiomarkers-
Palavras-chave: dc.subjectChild dentistry-
Palavras-chave: dc.subjectGenetics-
Palavras-chave: dc.subjectMatrix metalloproteinases-
Palavras-chave: dc.subjectOral diagnosis-
Palavras-chave: dc.subjectTemporomandibular disorders-
Título: dc.titleBruxism throughout the lifespan and variants in MMP2, MMP9 and COMT-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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