Effects of turmeric extract supplementation on inflammation and muscle damage after a half-marathon race: a randomized, double-blind, placebo-controlled trial

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Autor(es): dc.contributorUniversidade Federal de Goiás (UFG)-
Autor(es): dc.contributorUniversity of Alberta-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorFaria, Flávia Rasmussen-
Autor(es): dc.creatorGomes, Aline Corado-
Autor(es): dc.creatorAntunes, Alisson-
Autor(es): dc.creatorRezende, Kênnia Rocha-
Autor(es): dc.creatorPimentel, Gustavo Duarte-
Autor(es): dc.creatorOliveira, Camila Lemos Pinto-
Autor(es): dc.creatorAntunes, Barbara Moura [UNESP]-
Autor(es): dc.creatorLira, Fabio Santos [UNESP]-
Autor(es): dc.creatorAoki, Marcelo Saldanha-
Autor(es): dc.creatorMota, João Felipe-
Data de aceite: dc.date.accessioned2022-02-22T00:25:32Z-
Data de disponibilização: dc.date.available2022-02-22T00:25:32Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00421-020-04385-7-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/198797-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/198797-
Descrição: dc.descriptionPurpose: Strenuous exercise induces inflammation and muscle damage. Turmeric (Curcuma longa L.) is a widely used spice that exhibits potent anti-inflammatory response and appears to decrease indirect markers of muscle damage. A randomized, double-blind, placebo-controlled trial was conducted to evaluate the effects of Curcuma longa L. extract (CLE) on inflammation and muscle damage after a half-marathon race. Methods: Twenty-eight healthy, normal-weight men were randomly assigned to one of two groups: (1) CLE (3 capsules per day, 500 mg each); or (2) placebo (PLA, 3 capsules per day, 500 mg of microcrystalline cellulose). Participants received the intervention for 4 weeks and immediately before and after the half-marathon race. Creatine kinase, lactate dehydrogenase, alanine aminotransferase, aspartate aminotransferase, myoglobin, interleukins 6 and 10 were assessed at baseline, immediately before, after, and at 2, 24, and 48 h after the half-marathon race. Results: The half-marathon race increased markers of inflammation and muscle damage. A greater increase in interleukin-10 was observed in the CLE group immediately after the competition compared to the PLA group (7.54 ± 1.45 vs 5.25 ± 0.59 pg/mL; p < 0.05; d = 0.55). Myoglobin concentration was lower 2 h after the race in participants from the CLE group compared to the PLA group (62.10 ± 8.26 vs 107.85 ± 18.45 ng/mL; p = 0.01; d = 0.86). Conclusion: Curcuma longa L. extract supplementation leads to an increase in IL-10 and decreased myoglobin in recreational male runners after a half-marathon race. Trial registration number: U1111-1179-6335, February 13, 2016.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionClinical and Sports Nutrition Research Laboratory (LABINCE) School of Nutrition Federal University of Goiás, St. 227, Block 68, Setor Leste Universitário-
Descrição: dc.descriptionLaboratory of Biopharmacy and Pharmacokinetics Federal University of Goiás-
Descrição: dc.descriptionDepartment of Agricultural Food and Nutritional Science Human Nutrition Research Unit Faculty of Agricultural Life and Environmental Sciences University of Alberta-
Descrição: dc.descriptionDepartment of Physical Education Exercise and Immunometabolism Research Group São Paulo State University (UNESP)-
Descrição: dc.descriptionSchool of Arts Sciences and Humanities University of São Paulo-
Descrição: dc.descriptionDepartment of Physical Education Exercise and Immunometabolism Research Group São Paulo State University (UNESP)-
Descrição: dc.descriptionCNPq: 484023/2013-6-
Formato: dc.format1531-1540-
Idioma: dc.languageen-
Relação: dc.relationEuropean Journal of Applied Physiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCurcuma-
Palavras-chave: dc.subjectExercise-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectMuscle damage-
Título: dc.titleEffects of turmeric extract supplementation on inflammation and muscle damage after a half-marathon race: a randomized, double-blind, placebo-controlled trial-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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