Pathophysiological features of obesity and its impact on cognition: Exercise training as a non-pharmacological approach

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorThe University of Sydney-
Autor(es): dc.creatorInoue, Daniela S. [UNESP]-
Autor(es): dc.creatorAntunes, Bárbara M. [UNESP]-
Autor(es): dc.creatorMaideen, Mohammad F. B.-
Autor(es): dc.creatorLira, Fábio S. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:25:31Z-
Data de disponibilização: dc.date.available2022-02-22T00:25:31Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.2174/1381612826666200114102524-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/198785-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/198785-
Descrição: dc.descriptionBackground: The number of individuals with obesity is growing worldwide and this is a worrying trend, as obesity has shown to cause pathophysiological changes, which result in the emergence of comorbidities such as cardiovascular disease, diabetes mellitus type 2 and cancer. In addition, cognitive performance may be compromised by immunometabolic deregulation of obesity. Although in more critical cases, the use of medica-tions is recommended, a physically active lifestyle is one of the main foundations for health maintenance, making physical training an important tool to reduce the harmful effects of excessive fat accumulation. Aim: The purpose of this review of the literature is to present the impact of immunometabolic alterations on cognitive function in individuals with obesity, and the role of exercise training as a non-pharmacological approach to improve the inflammatory profile, energy metabolism and neuroplasticity in obesity. Method: An overview of the etiology and pathophysiology of obesity to establish a possible link with cognitive performance in obese individuals, with the executive function being one of the most affected cognitive compo-nents. In addition, the brain-derived neurotrophic factor (BDNF) profile and its impact on cognition in obese individuals are discussed. Lastly, studies showing regular resistance and/or aerobic training, which may be able to improve the pathophysiological condition and cognitive performance through the improvement of the inflammatory profile, decreased insulin resistance and higher BDNF production are discussed. Conclusion: Exercise training is essential for reestablishment and maintenance of health by increasing energy expenditure, insulin resistance reduction, anti-inflammatory proteins and neurotrophin production corroborating to upregulation of body function.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionExercise and Immunometabolism Research Group Department of Physical Education State University (UNESP) School of Technology and Sciences-
Descrição: dc.descriptionFaculty of Health Sciences Thermal Ergonomics Laboratory The University of Sydney-
Descrição: dc.descriptionCharles Perkins Centre The University of Sydney-
Descrição: dc.descriptionExercise and Immunometabolism Research Group Department of Physical Education State University (UNESP) School of Technology and Sciences-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 2015/22402-9-
Descrição: dc.descriptionFAPESP: 2016/16712-8-
Descrição: dc.descriptionFAPESP: 2017/03947-0-
Formato: dc.format916-931-
Idioma: dc.languageen-
Relação: dc.relationCurrent Pharmaceutical Design-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAdipose tissue-
Palavras-chave: dc.subjectCognition-
Palavras-chave: dc.subjectDiabetes mellitus type 2-
Palavras-chave: dc.subjectHormones-
Palavras-chave: dc.subjectNeuroinflammation-
Palavras-chave: dc.subjectPhysical activity-
Título: dc.titlePathophysiological features of obesity and its impact on cognition: Exercise training as a non-pharmacological approach-
Aparece nas coleções:Repositório Institucional - Unesp

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