Evaluation of lipid nanoparticles for topical delivery of protocatechuic acid and ethyl protocatechuate as a new photoprotection strategy

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Autor(es): dc.contributorUniversidade Estadual de Maringá (UEM)-
Autor(es): dc.contributorUniversity of Porto-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorIINFACTS – Institute for Research and Advanced Training in Health Sciences and Technologies-
Autor(es): dc.creatorDaré, Regina G.-
Autor(es): dc.creatorCosta, Ana-
Autor(es): dc.creatorNakamura, Celso V.-
Autor(es): dc.creatorTruiti, Maria C.T.-
Autor(es): dc.creatorXimenes, Valdecir F. [UNESP]-
Autor(es): dc.creatorLautenschlager, Sueli O.S.-
Autor(es): dc.creatorSarmento, Bruno-
Data de aceite: dc.date.accessioned2022-02-22T00:25:24Z-
Data de disponibilização: dc.date.available2022-02-22T00:25:24Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-05-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.ijpharm.2020.119336-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/198734-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/198734-
Descrição: dc.descriptionExcessive exposure to solar radiation induces injurious effects on human skin. Our previous study evidenced that protocatechuic acid (P0) and ethyl protocatechuate (P2) act against photodamage and photoaging. The present study aimed to develop solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) for topical delivery of P0 or P2, as a strategy for photoprotection. Lipid nanoparticles exhibited mean particle size, polydispersity index, zeta potential and association efficiency between 200 and 400 nm, 0.160 to 0.460, −2.2 to −5.2 mV, and 60% to 80%, respectively. The formulations were stable for 3 months when stored at 4○C and 25○C/60% RH. SLNs/NLCs-P0 showed minor cytotoxicity effects compared with SLNs/NLCs-P2, in HaCat (keratinocytes) and HFF-1 (fibroblasts) cell lines. Additionally, bare NLCs exhibited less cytotoxicity effect, compared with bare SLNs. NLCs exhibited a controlled in vitro release of P0 and P2, and were able to protect the compounds against UVB degradation. Ex vivo permeability study showed that NLCs modulated P0 and P2 retention profiles on human skin layers. Furthermore, histological analysis of skin showed that NLCs-P0 did not cause morphological alterations, while NLCs-P2 showed a potential irritation effect in the skin structure. Based on these results, NLCs were considered a potential dermatological nanocarrier for P0 delivery.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Pharmacy State University of Maringá (UEM)-
Descrição: dc.descriptioni3S – Institute for Research and Innovation in Health University of Porto, Rua Alfredo Allen, 208-
Descrição: dc.descriptionINEB – Institute of Biomedical Engineering University of Porto, Rua Alfredo Allen, 208-
Descrição: dc.descriptionDepartment of Chemistry Faculty of Sciences University of São Paulo (UNESP)-
Descrição: dc.descriptionCESPU IINFACTS – Institute for Research and Advanced Training in Health Sciences and Technologies, Rua Central de Gandra 1317-
Descrição: dc.descriptionDepartment of Chemistry Faculty of Sciences University of São Paulo (UNESP)-
Descrição: dc.descriptionFAPESP: 2014/50926-0-
Descrição: dc.descriptionCAPES: 88881.188573/2018-01-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Pharmaceutics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectEthyl protocatechuate-
Palavras-chave: dc.subjectFranz cells-
Palavras-chave: dc.subjectNanostructured lipid carriers-
Palavras-chave: dc.subjectProtocatechuic acid-
Palavras-chave: dc.subjectSolid lipid nanoparticles-
Palavras-chave: dc.subjectTopical delivery-
Título: dc.titleEvaluation of lipid nanoparticles for topical delivery of protocatechuic acid and ethyl protocatechuate as a new photoprotection strategy-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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