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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Estadual de Maringá (UEM) | - |
Autor(es): dc.contributor | University of Porto | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | IINFACTS – Institute for Research and Advanced Training in Health Sciences and Technologies | - |
Autor(es): dc.creator | Daré, Regina G. | - |
Autor(es): dc.creator | Costa, Ana | - |
Autor(es): dc.creator | Nakamura, Celso V. | - |
Autor(es): dc.creator | Truiti, Maria C.T. | - |
Autor(es): dc.creator | Ximenes, Valdecir F. [UNESP] | - |
Autor(es): dc.creator | Lautenschlager, Sueli O.S. | - |
Autor(es): dc.creator | Sarmento, Bruno | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:25:24Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:25:24Z | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2020-05-30 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1016/j.ijpharm.2020.119336 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/198734 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/198734 | - |
Descrição: dc.description | Excessive exposure to solar radiation induces injurious effects on human skin. Our previous study evidenced that protocatechuic acid (P0) and ethyl protocatechuate (P2) act against photodamage and photoaging. The present study aimed to develop solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) for topical delivery of P0 or P2, as a strategy for photoprotection. Lipid nanoparticles exhibited mean particle size, polydispersity index, zeta potential and association efficiency between 200 and 400 nm, 0.160 to 0.460, −2.2 to −5.2 mV, and 60% to 80%, respectively. The formulations were stable for 3 months when stored at 4○C and 25○C/60% RH. SLNs/NLCs-P0 showed minor cytotoxicity effects compared with SLNs/NLCs-P2, in HaCat (keratinocytes) and HFF-1 (fibroblasts) cell lines. Additionally, bare NLCs exhibited less cytotoxicity effect, compared with bare SLNs. NLCs exhibited a controlled in vitro release of P0 and P2, and were able to protect the compounds against UVB degradation. Ex vivo permeability study showed that NLCs modulated P0 and P2 retention profiles on human skin layers. Furthermore, histological analysis of skin showed that NLCs-P0 did not cause morphological alterations, while NLCs-P2 showed a potential irritation effect in the skin structure. Based on these results, NLCs were considered a potential dermatological nanocarrier for P0 delivery. | - |
Descrição: dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
Descrição: dc.description | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | - |
Descrição: dc.description | Department of Pharmacy State University of Maringá (UEM) | - |
Descrição: dc.description | i3S – Institute for Research and Innovation in Health University of Porto, Rua Alfredo Allen, 208 | - |
Descrição: dc.description | INEB – Institute of Biomedical Engineering University of Porto, Rua Alfredo Allen, 208 | - |
Descrição: dc.description | Department of Chemistry Faculty of Sciences University of São Paulo (UNESP) | - |
Descrição: dc.description | CESPU IINFACTS – Institute for Research and Advanced Training in Health Sciences and Technologies, Rua Central de Gandra 1317 | - |
Descrição: dc.description | Department of Chemistry Faculty of Sciences University of São Paulo (UNESP) | - |
Descrição: dc.description | FAPESP: 2014/50926-0 | - |
Descrição: dc.description | CAPES: 88881.188573/2018-01 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | International Journal of Pharmaceutics | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | Ethyl protocatechuate | - |
Palavras-chave: dc.subject | Franz cells | - |
Palavras-chave: dc.subject | Nanostructured lipid carriers | - |
Palavras-chave: dc.subject | Protocatechuic acid | - |
Palavras-chave: dc.subject | Solid lipid nanoparticles | - |
Palavras-chave: dc.subject | Topical delivery | - |
Título: dc.title | Evaluation of lipid nanoparticles for topical delivery of protocatechuic acid and ethyl protocatechuate as a new photoprotection strategy | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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