Predictive Model for Delivery Efficiency: Erythrocyte Membrane-Camouflaged Magnetofluorescent Nanocarriers Study

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Autor(es): dc.contributorUniversidade Federal de Goiás (UFG)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorSousa-Junior, Ailton A.-
Autor(es): dc.creatorMendanha, Sebastião A.-
Autor(es): dc.creatorCarrião, Marcus S.-
Autor(es): dc.creatorCapistrano, Gustavo-
Autor(es): dc.creatorPróspero, André G. [UNESP]-
Autor(es): dc.creatorSoares, Guilherme A. [UNESP]-
Autor(es): dc.creatorCintra, Emílio R.-
Autor(es): dc.creatorSantos, Sônia F.O.-
Autor(es): dc.creatorZufelato, Nicholas-
Autor(es): dc.creatorAlonso, Antônio-
Autor(es): dc.creatorLima, Eliana M.-
Autor(es): dc.creatorMiranda, José Ricardo A. [UNESP]-
Autor(es): dc.creatorSilveira-Lacerda, Elisângela De P.-
Autor(es): dc.creatorCardoso, Cléver G.-
Autor(es): dc.creatorBakuzis, Andris F.-
Data de aceite: dc.date.accessioned2022-02-22T00:25:00Z-
Data de disponibilização: dc.date.available2022-02-22T00:25:00Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-03-02-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1021/acs.molpharmaceut.9b01094-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/198599-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/198599-
Descrição: dc.descriptionDelivery efficiencies of theranostic nanoparticles (NPs) based on passive tumor targeting strongly depend either on their blood circulation time or on appropriate modulations of the tumor microenvironment. Therefore, predicting the NP delivery efficiency before and after a tumor microenvironment modulation is highly desirable. Here, we present a new erythrocyte membrane-camouflaged magnetofluorescent nanocarrier (MMFn) with long blood circulation time (92 h) and high delivery efficiency (10% ID for Ehrlich murine tumor model). MMFns owe their magnetic and fluorescent properties to the incorporation of manganese ferrite nanoparticles (MnFe2O4 NPs) and IR-780 (a lipophilic indocyanine fluorescent dye), respectively, to their erythrocyte membrane-derived camouflage. MMFn composition, morphology, and size, as well as optical absorption, zeta potential, and fluorescent, magnetic, and magnetothermal properties, are thoroughly examined in vitro. We then present an analytical pharmacokinetic (PK) model capable of predicting the delivery efficiency (DE) and the time of peak tumor uptake (tmax), as well as changes in DE and tmax due to modulations of the tumor microenvironment, for potentially any nanocarrier. Experimental PK data sets (blood and tumor amounts of MMFns) are simultaneously fit to the model equations using the PK modeling software Monolix. We then validate our model analytical solutions with the numerical solutions provided by Monolix. We also demonstrate how our a priori nonmechanistic model for passive targeting relates to a previously reported mechanistic model for active targeting. All in vivo PK studies, as well as in vivo and ex vivo biodistribution studies, were conducted using two noninvasive techniques, namely, fluorescence molecular tomography (FMT) and alternating current biosusceptometry (ACB). Finally, histopathology corroborates our PK and biodistribution results.-
Descrição: dc.descriptionPhysics Institute Federal University of Goiás-
Descrição: dc.descriptionBiomagnetism Lab Physics and Biophysics Department São Paulo State University-
Descrição: dc.descriptionLaboratory of Pharmaceutical Nanotechnology and Drug Delivery Systems School of Pharmacy Federal University of Goiás-
Descrição: dc.descriptionBiological Sciences Institute Federal University of Goiás-
Descrição: dc.descriptionBiomagnetism Lab Physics and Biophysics Department São Paulo State University-
Formato: dc.format837-851-
Idioma: dc.languageen-
Relação: dc.relationMolecular Pharmaceutics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectiron oxide-based nanoparticles-
Palavras-chave: dc.subjectmagnetic hyperthermia-
Palavras-chave: dc.subjectmembrane-coated nanoparticles-
Palavras-chave: dc.subjectnear-infrared dye-
Palavras-chave: dc.subjectpharmacokinetic model-
Palavras-chave: dc.subjectphotothermal therapy-
Palavras-chave: dc.subjecttumor delivery efficiency-
Título: dc.titlePredictive Model for Delivery Efficiency: Erythrocyte Membrane-Camouflaged Magnetofluorescent Nanocarriers Study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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