Microbiota modulation and effects on metabolic biomarkers by orange juice: a controlled clinical trial

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversity of California-
Autor(es): dc.contributorUNH CRNH Auvergne-
Autor(es): dc.creatorFidélix, Melaine [UNESP]-
Autor(es): dc.creatorMilenkovic, Dragan-
Autor(es): dc.creatorSivieri, Katia [UNESP]-
Autor(es): dc.creatorCesar, Thais [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:24:55Z-
Data de disponibilização: dc.date.available2022-02-22T00:24:55Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1039/c9fo02623a-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/198564-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/198564-
Descrição: dc.descriptionThe impact of habitual orange juice consumption on microbiota, lipid and sugar metabolism was investigated in a controlled clinical trial. The clinical procedure is as follows: ten women who had a regular diet without orange juice for 30 days (OJ-free diet), followed by a regular diet plus 300 ml d-1 orange juice for 60 days (OJ-Diet), and 30 days with a regular diet without orange juice (Washout). Biochemical and dietary parameters were monitored, and blood, urine and stool samples were collected every 30 days until the end of the study. Hesperidin and naringin metabolites in the urine were identified by UHPLC, and the microbiota composition of the feces was determined by 16S rRNA. At the end of the OJ-Diet, there was a reduction in glucose (-6.5%), insulin (-33%), insulin resistance (-44%), LDL-C (-16%) and triglycerides (-30%). After the washout, these parameters returned to their initial values. There were no changes in the body weight or fat during the experimental time. The intestinal bacteria, Lactobacillus spp., Akkermansia spp., and Ruminococcus spp., increased after the intervention with orange juice. In addition, an inverse correlation was detected between these bacteria and glycemia, insulin, HOMA-IR, triglycerides, total cholesterol and LDL-C, but a direct correlation with HDL-C. In conclusion, orange juice showed a prebiotic effect, modulating the intestinal microbiota while improving the glycemia and lipid profiles.-
Descrição: dc.descriptionLaboratory of Nutrition School of Pharmaceutical Science São Paulo State University-UNESP-
Descrição: dc.descriptionDepartment of Internal Medicine UC Davis School of Medicine University of California-
Descrição: dc.descriptionUniversité Clermont Auvergne INRA UNH CRNH Auvergne-
Descrição: dc.descriptionLaboratory of Nutrition School of Pharmaceutical Science São Paulo State University-UNESP-
Formato: dc.format1599-1610-
Idioma: dc.languageen-
Relação: dc.relationFood and Function-
???dc.source???: dc.sourceScopus-
Título: dc.titleMicrobiota modulation and effects on metabolic biomarkers by orange juice: a controlled clinical trial-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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