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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Iowa State University | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | Vet Resources International - AMVC Management Services | - |
Autor(es): dc.contributor | Corteva Agriscience | - |
Autor(es): dc.creator | Naberhaus, Samantha A. | - |
Autor(es): dc.creator | Krull, Adam C. | - |
Autor(es): dc.creator | Arruda, Bailey L. | - |
Autor(es): dc.creator | Arruda, Paulo | - |
Autor(es): dc.creator | Sahin, Orhan | - |
Autor(es): dc.creator | Schwartz, Kent J. | - |
Autor(es): dc.creator | Burrough, Eric R. | - |
Autor(es): dc.creator | Magstadt, Drew R. | - |
Autor(es): dc.creator | Matias Ferreyra, Franco | - |
Autor(es): dc.creator | Gatto, Igor R. H. [UNESP] | - |
Autor(es): dc.creator | Meiroz de Souza Almeida, Henrique [UNESP] | - |
Autor(es): dc.creator | Wang, Chong | - |
Autor(es): dc.creator | Kreuder, Amanda J. | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:24:46Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:24:46Z | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2020-01-29 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.3389/fvets.2019.00502 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/198525 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/198525 | - |
Descrição: dc.description | Since 2014, Salmonella 4,[5],12:i:- has emerged as the most common serovar of Salmonella enterica identified from swine samples submitted to veterinary diagnostic laboratories in the United States. To compare the pathogenicity of S. 4,[5],12:i:- in swine to the known pathogenic Salmonella Typhimurium and lesser pathogenic Salmonella Derby, 72 pigs (20 per Salmonella serovar treatment and 12 controls) were inoculated with either S. Typhimurium, S. 4,[5],12:i:-, S. Derby, or sham-inoculated and followed for up to 28 days thereafter via rectal temperature, fecal scoring, and fecal culture. Animals were euthanized on days 2, 4, or 28 to determine the gross and histopathologic signs of disease and tissue colonization. The results clearly demonstrate that for the isolates selected, serovar 4,[5],12:i:- possesses similar ability as serovar Typhimurium to cause clinical disease, colonize the tonsils and ileocecal lymph nodes, and be shed in the feces of infected swine past resolution of clinical disease. To compare the competitive fitness of S. 4,[5],12:i:- to S. Typhimurium in swine when co-infected, 12 pigs were co-inoculated with equal concentrations of both S. Typhimurium and S. 4,[5],12:i and followed for up to 10 days thereafter. When co-inoculated, serovar 4,[5],12:i:- was consistently detected in the feces of a higher percentage of pigs and at higher concentrations than serovar Typhimurium, suggesting an increased competitive fitness of 4,[5],12:i:- relative to serovar Typhimurium when inoculated simultaneously into naïve pigs. Whole genome sequencing analysis of the isolates used in these studies revealed similar virulence factor presence in all S. 4,[5],12:i:- and S. Typhimurium isolates, but not S. Derby, providing additional evidence for similar pathogenicity potential between serovars 4,[5],12:i:- and Typhimurium. Altogether, this data strongly supports the hypothesis that S. 4,[5],12:i:- is a pathogen of swine and suggests a mechanism through increased competitive fitness for the increasing identification of Salmonella 4,[5],12:i:- in swine diagnostic samples over the past several years. | - |
Descrição: dc.description | National Pork Board | - |
Descrição: dc.description | Department of Veterinary Diagnostic and Production Animal Medicine College of Veterinary Medicine Iowa State University | - |
Descrição: dc.description | Department of Statistics College of Liberal Arts and Sciences Iowa State University | - |
Descrição: dc.description | Department of Veterinary Microbiology and Preventive Medicine College of Veterinary Medicine Iowa State University | - |
Descrição: dc.description | School of Agricultural and Veterinarian Sciences Preventive Veterinary Medicine and Animal Reproduction São Paulo State University (unesp) | - |
Descrição: dc.description | Vet Resources International - AMVC Management Services | - |
Descrição: dc.description | Corteva Agriscience | - |
Descrição: dc.description | School of Agricultural and Veterinarian Sciences Preventive Veterinary Medicine and Animal Reproduction São Paulo State University (unesp) | - |
Descrição: dc.description | National Pork Board: 16-215 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Frontiers in Veterinary Science | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | 4,[5],12:i:- | - |
Palavras-chave: dc.subject | Derby | - |
Palavras-chave: dc.subject | monophasic | - |
Palavras-chave: dc.subject | pathogenesis | - |
Palavras-chave: dc.subject | porcine | - |
Palavras-chave: dc.subject | Salmonella | - |
Palavras-chave: dc.subject | swine | - |
Palavras-chave: dc.subject | Typhimurium | - |
Título: dc.title | Pathogenicity and Competitive Fitness of Salmonella enterica Serovar 4,[5],12:i:- Compared to Salmonella Typhimurium and Salmonella Derby in Swine | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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