A topical cell therapy approach for diabetic chronic ulcers: Effects of mesenchymal stromal cells associated with platelet-rich plasma

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorCordCell CellTherapy-
Autor(es): dc.creatorStessuk, Talita-
Autor(es): dc.creatorRibeiro-Paes, João Tadeu [UNESP]-
Autor(es): dc.creatorColpas, Paula Tavares-
Autor(es): dc.creatorMartins Alves, Paulo César-
Autor(es): dc.creatorRehder, Jussara-
Autor(es): dc.creatorBosnardo, Carla Aparecida Faccio-
Autor(es): dc.creatorGuillaumon, Ana Terezinha-
Autor(es): dc.creatorForte, Andresa-
Autor(es): dc.creatorPuzzi, Maria Beatriz-
Data de aceite: dc.date.accessioned2022-02-22T00:24:46Z-
Data de disponibilização: dc.date.available2022-02-22T00:24:46Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/jocd.13321-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/198524-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/198524-
Descrição: dc.descriptionBackground: Diabetic cutaneous ulcers are subjected to several physiological and biochemical defects, which contribute to wound chronicity and therapeutic failure. Platelet-rich plasma (PRP) has been used for stimulating tissue regeneration, and mesenchymal stromal cells (MSCs) have demonstrated therapeutic properties in all phases of skin regeneration in cell therapy studies. Aims: The objective of this study was to evaluate the therapeutic effects related to the use of a biomembrane composed of autologous MSCs and PRP on chronic wounds of diabetic patients (pre-post pilot study). Patients/Methods: Six diabetic patients with chronic wounds for more than 6 months were subjected to adipose tissue collection for isolation of MSCs, blood collection for PRP preparation, and topical administration of a biomembrane of MSCs and PRP on each chronic wound. The statistical difference regarding the evolution of ulcers was calculated by means of paired t test. Results: There was granulation tissue formation starting from 7 days after topical application. Total re-epithelialization occurred in 5 of the 9 lesions treated, and the mean wound healing rate (WHR) was 74.55% (±32.55%) after 90 days. No cicatricial hypertrophy or retraction was observed. Conclusion: Mesenchymal stromal cells topical therapy associated with PRP is well-tolerated and able to provide a reduction in ulcer area of diabetic chronic wounds.-
Descrição: dc.descriptionUniversity of São Paulo USP-
Descrição: dc.descriptionSão Paulo State University UNESP–Campus de Assis-
Descrição: dc.descriptionUniversity of Campinas UNICAMP-
Descrição: dc.descriptionCordCell CellTherapy-
Descrição: dc.descriptionSão Paulo State University UNESP–Campus de Assis-
Idioma: dc.languageen-
Relação: dc.relationJournal of Cosmetic Dermatology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcell therapy-
Palavras-chave: dc.subjectdiabetes mellitus-
Palavras-chave: dc.subjectmesenchymal stromal cells-
Palavras-chave: dc.subjectplatelet-rich plasma-
Palavras-chave: dc.subjectwound healing-
Título: dc.titleA topical cell therapy approach for diabetic chronic ulcers: Effects of mesenchymal stromal cells associated with platelet-rich plasma-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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