Developmental genome-wide DNA methylation asymmetry between mouse placenta and embryo

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorResearch Center of the CHU Sainte-Justine-
Autor(es): dc.contributorUniversité De Montréal-
Autor(es): dc.contributorResearch Institute of the McGill University Health Centre-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorMcGill University-
Autor(es): dc.contributorMcGill University and Genome Quebec Innovation Centre-
Autor(es): dc.contributorCanadian Center for Computational Genomics-
Autor(es): dc.creatorLegault, L. M.-
Autor(es): dc.creatorDoiron, K.-
Autor(es): dc.creatorLemieux, A.-
Autor(es): dc.creatorCaron, M.-
Autor(es): dc.creatorChan, D.-
Autor(es): dc.creatorLopes, F. L. [UNESP]-
Autor(es): dc.creatorBourque, G.-
Autor(es): dc.creatorSinnett, D.-
Autor(es): dc.creatorMcGraw, S.-
Data de aceite: dc.date.accessioned2022-02-22T00:24:45Z-
Data de disponibilização: dc.date.available2022-02-22T00:24:45Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-08-02-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/15592294.2020.1722922-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/198519-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/198519-
Descrição: dc.descriptionIn early embryos, DNA methylation is remodelled to initiate the developmental program but for mostly unknown reasons, methylation marks are acquired unequally between embryonic and placental cells. To better understand this, we generated high-resolution DNA methylation maps of mouse mid-gestation (E10.5) embryo and placenta. We uncovered specific subtypes of differentially methylated regions (DMRs) that contribute directly to the developmental asymmetry existing between mid-gestation embryonic and placental DNA methylation patterns. We show that the asymmetry occurs rapidly during the acquisition of marks in the post-implanted conceptus (E3.5-E6.5), and that these patterns are long-lasting across subtypes of DMRs throughout prenatal development and in somatic tissues. We reveal that at the peri–implantation stages, the de novo methyltransferase activity of DNMT3B is the main driver of methylation marks on asymmetric DMRs, and that DNMT3B can largely compensate for lack of DNMT3A in the epiblast and extraembryonic ectoderm, whereas DNMT3A can only partially compensate in the absence of DNMT3B. However, as development progresses and as DNMT3A becomes the principal de novo methyltransferase, the compensatory DNA methylation mechanism of DNMT3B on DMRs becomes less effective.-
Descrição: dc.descriptionResearch Center of the CHU Sainte-Justine-
Descrição: dc.descriptionDepartment of Biochemistry and Molecular Medicine Université De Montréal-
Descrição: dc.descriptionResearch Institute of the McGill University Health Centre-
Descrição: dc.descriptionSchool of Veterinary Medicine São Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Human Genetics McGill University-
Descrição: dc.descriptionMcGill University and Genome Quebec Innovation Centre-
Descrição: dc.descriptionCanadian Center for Computational Genomics-
Descrição: dc.descriptionDepartment of Pediatrics Université De Montréal-
Descrição: dc.descriptionDepartment of Obstetrics and Gynecology Université De Montréal-
Descrição: dc.descriptionSchool of Veterinary Medicine São Paulo State University (Unesp)-
Formato: dc.format800-815-
Idioma: dc.languageen-
Relação: dc.relationEpigenetics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDNA methylation-
Palavras-chave: dc.subjectearly development-
Palavras-chave: dc.subjectembryo-
Palavras-chave: dc.subjectplacenta-
Título: dc.titleDevelopmental genome-wide DNA methylation asymmetry between mouse placenta and embryo-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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