The use of sulfonamide derivatives in the treatment of trypanosomatid parasites including trypanosoma cruzi, trypanosoma brucei, and leishmania ssp

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorScarim, Cauê B. [UNESP]-
Autor(es): dc.creatorChelucci, Rafael C. [UNESP]-
Autor(es): dc.creatorDos Santos, Jean L. [UNESP]-
Autor(es): dc.creatorChin, Chung M. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:24:36Z-
Data de disponibilização: dc.date.available2022-02-22T00:24:36Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.2174/1573406415666190620141109-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/198453-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/198453-
Descrição: dc.descriptionMore than 10 million people around the world are afflicted by Neglected Tropical Diseases, such as Chagas Disease, Human African Trypanosomiasis, and Leishmania. These diseases mostly occur in undeveloped countries that suffer from a lack of economic incentive, research, and policy for new compound development. Sulfonamide moieties are effective scaffolds present in several compounds that are determinants to treat various diseases, principally neglected tropical diseases. This review article examines the contribution of these scaffolds in medicinal chemistry in the last five years, focusing on three trypanosomatid parasites: Trypanosoma cruzi, Trypanosoma brucei, and Leishmania ssp. We also present perspectives for their use in drug designs in an effort to contribute to new drug development. In addition, we consider the physicochemical parameters, whose molecules all presented according to Lipinski's rule. The correlation between the selective index and LogP was evaluated, showing that sulfonamide derivatives can act differently against each trypanosomatid parasite. Moreover, the approaches of novel drugs and technologies are very important for the eventual drug discovery against trypanosomatid diseases.-
Descrição: dc.descriptionUniversidade Estadual Paulista-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Pharmaceutical Sciences-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Pharmaceutical Sciences-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 2016/10847-9-
Formato: dc.format24-38-
Idioma: dc.languageen-
Relação: dc.relationMedicinal Chemistry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectChagas disease-
Palavras-chave: dc.subjectHuman African Trypanosomiasis (HAT)-
Palavras-chave: dc.subjectLeishmania-
Palavras-chave: dc.subjectNew compounds-
Palavras-chave: dc.subjectSulfonamides-
Palavras-chave: dc.subjectTropical Diseases-
Título: dc.titleThe use of sulfonamide derivatives in the treatment of trypanosomatid parasites including trypanosoma cruzi, trypanosoma brucei, and leishmania ssp-
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