Anxiogenesis induced by social defeat in male mice: Role of nitric oxide, NMDA, and CRF1 receptors in the medial prefrontal cortex and BNST

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorFaria, M. P. [UNESP]-
Autor(es): dc.creatorLaverde, C. F. [UNESP]-
Autor(es): dc.creatorNunes-de-Souza, R. L. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:24:34Z-
Data de disponibilização: dc.date.available2022-02-22T00:24:34Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.neuropharm.2020.107973-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/198444-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/198444-
Descrição: dc.descriptionNitric oxide (NO) release in the right medial prefrontal cortex (RmPFC) produces anxiogenesis. In the bed nucleus of the stria terminalis (BNST), a region that receives neuronal projections from the mPFC, NO provokes anxiety, an effect that is blocked by local injections of corticotrophin-releasing factor type 1 receptor (CRF1) or n-methyl-D-aspartate receptor (NMDAr) antagonist. Anxiety is also enhanced by social defeat stress, and chronic stress impairs and facilitates, respectively, PFC and BNST roles in modulating behavioral responses to aversive situations. This study investigated whether the (i) chronic social defeat stress (CSDS) increases NO signaling in the mPFC; and/or (ii) anxiogenic effects provoked by the intra-RmPFC injection of NOC-9 (an NO donor) or by CSDS are prevented by intra-BNST injections of AP-7 (0.05 nmol) or CP 376395 (3.0 nmol), respectively, NMDAr and CRF1 antagonists, in male Swiss-Webster mice exposed to the elevated plus-maze (EPM). Results showed that (a) CSDS increased anxiety (i.e., reduced open-arm exploration) and repeatedly activated nNOS-containing neurons, as measured by ΔFosB (a stable nonspecific marker of neural activity) + nNOS double-labeling, in the right (but not left) mPFC, (b) NOC-9 in the RmPFC also increased anxiety, and (c) both CSDS and NOC-9 effects were reversed by injections of AP-7 or CP 376395 into the BNST. These results suggest that NMDA and CRF1 receptors located in BNST play an important role in the modulation of anxiety provoked by NO in the RmPFC, as well as by chronic social defeat in mice.-
Descrição: dc.descriptionASCRS Research Foundation-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionJoint Graduate Program of Physiological Sciences (PIPGCF) UFSCar-UNESP-
Descrição: dc.descriptionSão Paulo State University (Unesp) School of Pharmaceutical Sciences Lab. Pharmacology-
Descrição: dc.descriptionJoint Graduate Program of Physiological Sciences (PIPGCF) UFSCar-UNESP-
Descrição: dc.descriptionSão Paulo State University (Unesp) School of Pharmaceutical Sciences Lab. Pharmacology-
Descrição: dc.descriptionFAPESP: 2013/01383-6-
Descrição: dc.descriptionFAPESP: 2017/25409-0-
Descrição: dc.descriptionCAPES: 2053/2013-
Descrição: dc.descriptionCNPq: 306556/2015-4-
Descrição: dc.descriptionCNPq: 478696/2013-2-
Idioma: dc.languageen-
Relação: dc.relationNeuropharmacology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAnxiety-
Palavras-chave: dc.subjectFosB + nNOS double-labeling-
Palavras-chave: dc.subjectmPFC and BNST-
Palavras-chave: dc.subjectNitric oxide-
Palavras-chave: dc.subjectNMDA and CRF1 receptors-
Palavras-chave: dc.subjectSocially defeated mice-
Palavras-chave: dc.subjectΔ-
Título: dc.titleAnxiogenesis induced by social defeat in male mice: Role of nitric oxide, NMDA, and CRF1 receptors in the medial prefrontal cortex and BNST-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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