A novel strategy for glioblastoma treatment combining alpha-cyano-4-hydroxycinnamic acid with cetuximab using nanotechnology-based delivery systems

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversity of Minho-
Autor(es): dc.contributorICVS/3B’s-PT Government Associate Laboratory-
Autor(es): dc.contributorBarretos Cancer Hospital-
Autor(es): dc.creatorFerreira, Natália N. [UNESP]-
Autor(es): dc.creatorGranja, Sara-
Autor(es): dc.creatorBoni, Fernanda Isadora [UNESP]-
Autor(es): dc.creatorFerreira, Leonardo M. B. [UNESP]-
Autor(es): dc.creatorReis, Rui M.-
Autor(es): dc.creatorBaltazar, Fátima-
Autor(es): dc.creatorGremião, Maria Palmira D. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:24:29Z-
Data de disponibilização: dc.date.available2022-02-22T00:24:29Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s13346-020-00713-8-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/198422-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/198422-
Descrição: dc.descriptionCombination therapy that uses multiple drugs against different molecular targets should be considered as interesting alternatives for treating complex diseases such as glioblastoma (GBM). Drugs like alpha-cyano-4-hydroxycinnamic acid (CHC) and the monoclonal antibody cetuximab (CTX) are already explored for their capacity to act against different hallmarks of cancer. Previous reports suggest that the simultaneous use of these drugs, as a novel combining approach, might result in additive or synergistic effects. Therefore, advances in nanotechnology-based delivery systems will inevitably bring nano-mediated therapeutic gains to the proposed combination since they enable the association of different drugs into a single carrier. The current study provides indications that the new dual therapeutic strategy proposed, in association with nanotechnology, provides significative improvements when compared to the use of isolated drugs. Nanotechnological tools were employed by developing polymeric nanoparticles based on poly(lactic-co-glycolic acid) and chitosan for CHC encapsulation. Furthermore, these structures were conjugated with CTX by supramolecular forces. In summary, the encapsulation of the CHC drug into the nanoparticles increased its individual therapeutic capacity. In addition, conjugation with CTX seemed to enhance therapeutic efficacy, especially for U251 GBM cells. In conclusion, developed nanostructured delivery systems exhibited a set of favorable attributes and potential to be applied as a promising new alternative for GBM treatment. [Figure not available: see fulltext.]-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação para a Ciência e a Tecnologia-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University UNESP, Rodovia Araraquara/Jaú Km 1-
Descrição: dc.descriptionLife and Health Sciences Research Institute (ICVS) School of Medicine University of Minho-
Descrição: dc.descriptionICVS/3B’s-PT Government Associate Laboratory-
Descrição: dc.descriptionMolecular Oncology Research Center Barretos Cancer Hospital-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University UNESP, Rodovia Araraquara/Jaú Km 1-
Descrição: dc.descriptionFAPESP: 2014/50928-2-
Descrição: dc.descriptionFAPESP: 2016/09671-3-
Descrição: dc.descriptionFAPESP: 2018/ 04546-1-
Descrição: dc.descriptionCNPq: 465687/2014-8-
Descrição: dc.descriptionFundação para a Ciência e a Tecnologia: SFRH/BPD/117858/2016-
Formato: dc.format594-609-
Idioma: dc.languageen-
Relação: dc.relationDrug Delivery and Translational Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCetuximab-
Palavras-chave: dc.subjectCombinatory effect-
Palavras-chave: dc.subjectGlioblastoma-
Palavras-chave: dc.subjectNanotechnology-
Palavras-chave: dc.subjectNovel therapeutic strategy-
Palavras-chave: dc.subjectα-Cyano-4-hydroxycinnamic acid-
Título: dc.titleA novel strategy for glioblastoma treatment combining alpha-cyano-4-hydroxycinnamic acid with cetuximab using nanotechnology-based delivery systems-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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