Evaluation of the uterine hormonal control of the bat Artibeus lituratus during the different phases of its reproductive cycle

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUFOB - Universidade Federal do Oeste da Bahia-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Federal de Goiás (UFG)-
Autor(es): dc.creatorSantiago, Cornélio S.-
Autor(es): dc.creatorAlbernaz, Edna S. S.-
Autor(es): dc.creatorSantos, Renata T. S.-
Autor(es): dc.creatorGuerra, Luiz H. A. [UNESP]-
Autor(es): dc.creatorSantos, Fernanda C. A.-
Autor(es): dc.creatorGóes, Rejane M. [UNESP]-
Autor(es): dc.creatorMorielle-Versute, Eliana [UNESP]-
Autor(es): dc.creatorTaboga, Sebastião R. [UNESP]-
Autor(es): dc.creatorBeguelini, Mateus R.-
Data de aceite: dc.date.accessioned2022-02-22T00:24:26Z-
Data de disponibilização: dc.date.available2022-02-22T00:24:26Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/jmor.21098-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/198402-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/198402-
Descrição: dc.descriptionArtibeus lituratus is a frugivorous bat that directly assists in the restoration of degraded habitats through the effective dispersion of seeds and fruits. Given its great importance, this work aimed to evaluate the uterine hormonal control of A. lituratus during its different reproductive phases. The uteri of 30 sexually mature adult females, five specimens for each of the six sample groups (NON, nonreproductive; P1, initial pregnancy; P2, intermediate pregnancy; P3, advanced pregnancy; LAC, lactating; P + LAC, pregnant-lactating), were submitted to analyses of serum estradiol and progesterone concentrations, in addition to immunohistochemical analyses. Both estradiol and progesterone, gradually increased during pregnancy, with a marked significant increase in P3 females. Both returned to low levels in LAC-females; however, estradiol levels decreased further in P + LAC-females, while progesterone increased in the same group. In general, signs indicative of aromatase expression were observed in the endometrium of all analyzed groups and in the placenta of bats in the gestation groups. Similarly, ERα and PR were expressed in the myometrium, endometrium and placenta at varying levels of intensity. The results indicate that the uterine microenvironment of A. lituratus is directly regulated by serum concentrations of estradiol and progesterone, and fluctuations in these concentrations control morphological and physiological changes of this organ during different phases of the reproductive cycle. Research highlights: Increases in serum concentrations of estradiol and progesterone coordinate the gestational period of A. lituratus. Estradiol activates ERα, stimulating cell proliferation in the uterus, in addition to activating the expression of PR, which trigger the quiescence of the myometrium and stimulation of the secretion and differentiation of the endometrium. Results showed several similarities to humans, indicating the use of A. lituratus as an animal model in reproductive studies.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado da Bahia-
Descrição: dc.descriptionCenter of Biological and Health Science UFOB - Universidade Federal do Oeste da Bahia-
Descrição: dc.descriptionDepartment of Biology UNESP – Univ. Estadual Paulista-
Descrição: dc.descriptionDepartment of Histology and Embryology UFG – Universidade Federal de Goiás-
Descrição: dc.descriptionDepartment of Zoology and Botany UNESP – Univ. Estadual Paulista-
Descrição: dc.descriptionDepartment of Biology UNESP – Univ. Estadual Paulista-
Descrição: dc.descriptionDepartment of Zoology and Botany UNESP – Univ. Estadual Paulista-
Descrição: dc.descriptionCNPq: 407106/2018-9-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado da Bahia: 7616/2015-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado da Bahia: 9038/2015-
Formato: dc.format302-315-
Idioma: dc.languageen-
Relação: dc.relationJournal of Morphology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectChiroptera-
Palavras-chave: dc.subjectestradiol-
Palavras-chave: dc.subjectprogesterone-
Palavras-chave: dc.subjectreproduction-
Palavras-chave: dc.subjectuterus-
Título: dc.titleEvaluation of the uterine hormonal control of the bat Artibeus lituratus during the different phases of its reproductive cycle-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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