Current approaches to drug discovery for chagas disease: Methodological advances

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorLapdesf-Laboratory of Research and Development of Drugs-
Autor(es): dc.creatorScarim, Cauê B. [UNESP]-
Autor(es): dc.creatorChin, Chung M. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:24:19Z-
Data de disponibilização: dc.date.available2022-02-22T00:24:19Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.2174/1386207322666191010144111-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/198355-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/198355-
Descrição: dc.descriptionBackground: In recent years, there has been an improvement in the in vitro and in vivo methodology for the screening of anti-chagasic compounds. Millions of compounds can now have their activity evaluated (in large compound libraries) by means of high throughput in vitro screening assays. Objective: Current approaches to drug discovery for Chagas disease. Method: This review article examines the contribution of these methodological advances in medicinal chemistry in the last four years, focusing on Trypanosoma cruzi infection, obtained from the PubMed, Web of Science, and Scopus databases. Results: Here, we have shown that the promise is increasing each year for more lead compounds for the development of a new drug against Chagas disease. Conclusion: There is increased optimism among those working with the objective to find new drug candidates for optimal treatments against Chagas disease.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Pharmaceutical Sciences-
Descrição: dc.descriptionLapdesf-Laboratory of Research and Development of Drugs-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Pharmaceutical Sciences-
Descrição: dc.descriptionFAPESP: 2016/10847-9-
Formato: dc.format509-520-
Idioma: dc.languageen-
Relação: dc.relationCombinatorial Chemistry and High Throughput Screening-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBioluminescence imaging-
Palavras-chave: dc.subjectChagas disease-
Palavras-chave: dc.subjectDrug development-
Palavras-chave: dc.subjectMethodological advances-
Palavras-chave: dc.subjectNew drugs-
Palavras-chave: dc.subjectTrypanosoma cruzi-
Título: dc.titleCurrent approaches to drug discovery for chagas disease: Methodological advances-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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