Hypotensive effect of Eugenia dysenterica leaf extract is primarily related to its vascular action: The possible underlying mechanisms

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Federal de Mato Grosso do Sul (UFMS)-
Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.creatorFidelis-de-Oliveira, Patrícia [UNESP]-
Autor(es): dc.creatorAparecida-Castro, Samanta [UNESP]-
Autor(es): dc.creatorSilva, Denise Brentan-
Autor(es): dc.creatorMorais, Ingrid Beatriz de Melo-
Autor(es): dc.creatorMiranda, Victor Hugo Martins de [UNESP]-
Autor(es): dc.creatorde Gobbi, Juliana Irani [UNESP]-
Autor(es): dc.creatorCanabrava, Hudson Armando Nunes-
Autor(es): dc.creatorBispo-da-Silva, Luiz Borges-
Data de aceite: dc.date.accessioned2022-02-22T00:24:12Z-
Data de disponibilização: dc.date.available2022-02-22T00:24:12Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-04-06-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jep.2019.112520-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/198323-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/198323-
Descrição: dc.descriptionEthnopharmacological relevance: Eugenia dysenterica (ED) leaves are used in Brazil to treat cardiac diseases; however, there are no scientific data describing the effects of this species on cardiac activity. Aim of the study: To investigate the effect of ED aqueous leaf extract (EDLE) on hear rate (HR) and mean arterial pressure (MAP) of anaesthetised rats and its underlying mechanism of action. Material and methods: EDLE was analysed, and its proanthocyanidin composition was determined. After performing dose-effect curves for EDLE on HR and MAP, EDLE-induced hypotension was evaluated before and after atropine (AT), L-N(ω)-nitro-L-arginine methyl ester (L-NAME), hexamethonium (HXT), indomethacin (IND), carbenoxolone (CBX), or nifedipine (NFD) administration. The effect of proanthocyanidin-depleted extract (EDLE/P-) was also determined and compared to that of the EDLE with proanthocyanidins. Results: EDLE decreased the MAP in a dose-dependent manner; HR was decreased only with the highest and most toxic dose. Only CBX and NFD decreased EDLE-induced hypotension. Five polymeric series of proanthocyanidins were identified, which were mainly constituted by procyanidin and prodelphinidin units with B-type linkage and up to 12 flavan-3-ol units. EDLE/P- induced hypotension did not differ from that induced by EDLE. Conclusions: The cardiovascular effects of EDLE were primarily related to its vascular action. EDLE-induced hypotensive effect appeared to involve L-type calcium channel blockage as well as myoendothelial gap junction signalling. The higher molecular weight proanthocyanidins from EDLE are unlikely to contribute to its cardiovascular effect.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSão Paulo State University/UNESP Department of Physiology Institute of Biosciences-
Descrição: dc.descriptionFederal University of Mato Grosso do Sul/UFMS Laboratório de Produtos Naturais e Espectrometria de Massas (LAPNEM)-
Descrição: dc.descriptionFederal University of Uberlândia/UFU Department of Pharmacology Institute of Biomedical Sciences Campus Umuarama-
Descrição: dc.descriptionSão Paulo State University/UNESP Department of Physiology Institute of Biosciences-
Descrição: dc.descriptionFAPESP: 2013/18382-7-
Idioma: dc.languageen-
Relação: dc.relationJournal of Ethnopharmacology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectEugenia dysenterica-
Palavras-chave: dc.subjectHeart-
Palavras-chave: dc.subjectHypotension-
Palavras-chave: dc.subjectLeaves-
Palavras-chave: dc.subjectMALDI-TOF-
Palavras-chave: dc.subjectProanthocyanidins-
Título: dc.titleHypotensive effect of Eugenia dysenterica leaf extract is primarily related to its vascular action: The possible underlying mechanisms-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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