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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | Universidade Federal de Mato Grosso do Sul (UFMS) | - |
Autor(es): dc.contributor | Universidade Federal de Uberlândia (UFU) | - |
Autor(es): dc.creator | Fidelis-de-Oliveira, Patrícia [UNESP] | - |
Autor(es): dc.creator | Aparecida-Castro, Samanta [UNESP] | - |
Autor(es): dc.creator | Silva, Denise Brentan | - |
Autor(es): dc.creator | Morais, Ingrid Beatriz de Melo | - |
Autor(es): dc.creator | Miranda, Victor Hugo Martins de [UNESP] | - |
Autor(es): dc.creator | de Gobbi, Juliana Irani [UNESP] | - |
Autor(es): dc.creator | Canabrava, Hudson Armando Nunes | - |
Autor(es): dc.creator | Bispo-da-Silva, Luiz Borges | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:24:12Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:24:12Z | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2020-04-06 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1016/j.jep.2019.112520 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/198323 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/198323 | - |
Descrição: dc.description | Ethnopharmacological relevance: Eugenia dysenterica (ED) leaves are used in Brazil to treat cardiac diseases; however, there are no scientific data describing the effects of this species on cardiac activity. Aim of the study: To investigate the effect of ED aqueous leaf extract (EDLE) on hear rate (HR) and mean arterial pressure (MAP) of anaesthetised rats and its underlying mechanism of action. Material and methods: EDLE was analysed, and its proanthocyanidin composition was determined. After performing dose-effect curves for EDLE on HR and MAP, EDLE-induced hypotension was evaluated before and after atropine (AT), L-N(ω)-nitro-L-arginine methyl ester (L-NAME), hexamethonium (HXT), indomethacin (IND), carbenoxolone (CBX), or nifedipine (NFD) administration. The effect of proanthocyanidin-depleted extract (EDLE/P-) was also determined and compared to that of the EDLE with proanthocyanidins. Results: EDLE decreased the MAP in a dose-dependent manner; HR was decreased only with the highest and most toxic dose. Only CBX and NFD decreased EDLE-induced hypotension. Five polymeric series of proanthocyanidins were identified, which were mainly constituted by procyanidin and prodelphinidin units with B-type linkage and up to 12 flavan-3-ol units. EDLE/P- induced hypotension did not differ from that induced by EDLE. Conclusions: The cardiovascular effects of EDLE were primarily related to its vascular action. EDLE-induced hypotensive effect appeared to involve L-type calcium channel blockage as well as myoendothelial gap junction signalling. The higher molecular weight proanthocyanidins from EDLE are unlikely to contribute to its cardiovascular effect. | - |
Descrição: dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
Descrição: dc.description | São Paulo State University/UNESP Department of Physiology Institute of Biosciences | - |
Descrição: dc.description | Federal University of Mato Grosso do Sul/UFMS Laboratório de Produtos Naturais e Espectrometria de Massas (LAPNEM) | - |
Descrição: dc.description | Federal University of Uberlândia/UFU Department of Pharmacology Institute of Biomedical Sciences Campus Umuarama | - |
Descrição: dc.description | São Paulo State University/UNESP Department of Physiology Institute of Biosciences | - |
Descrição: dc.description | FAPESP: 2013/18382-7 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Journal of Ethnopharmacology | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | Eugenia dysenterica | - |
Palavras-chave: dc.subject | Heart | - |
Palavras-chave: dc.subject | Hypotension | - |
Palavras-chave: dc.subject | Leaves | - |
Palavras-chave: dc.subject | MALDI-TOF | - |
Palavras-chave: dc.subject | Proanthocyanidins | - |
Título: dc.title | Hypotensive effect of Eugenia dysenterica leaf extract is primarily related to its vascular action: The possible underlying mechanisms | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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