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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | Universidade Estadual de Campinas (UNICAMP) | - |
Autor(es): dc.creator | Araujo, Cássia F [UNESP] | - |
Autor(es): dc.creator | Andere, Naira M R B [UNESP] | - |
Autor(es): dc.creator | Castro Dos Santos, Nídia C [UNESP] | - |
Autor(es): dc.creator | Mathias-Santamaria, Ingrid F. [UNESP] | - |
Autor(es): dc.creator | Reis, Aurélio A | - |
Autor(es): dc.creator | de Oliveira, Luciane D. [UNESP] | - |
Autor(es): dc.creator | Jardini, Maria A N [UNESP] | - |
Autor(es): dc.creator | Casarin, Renato C V | - |
Autor(es): dc.creator | Santamaria, Mauro P. [UNESP] | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:24:05Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:24:05Z | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2019-11-30 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1002/JPER.18-0399 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/198275 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/198275 | - |
Descrição: dc.description | BACKGROUND: To assess the clinical and microbiological responses of amoxicillin + metronidazole (AMX + MET) versus clarithromycin (CLM) as adjuncts to one-stage full-mouth ultrasonic debridement (FMUD) in the treatment of generalized aggressive periodontitis (GAgP). METHODS: For this parallel, double-masked, pilot randomized clinical trial, 46 patients with GAgP were selected and randomly assigned into two groups: AMX+MET group (n = 23): FMUD associated with AMX (500 mg three times a day) and MET (400 mg three times a day) for 7 days; and CLM group (n = 23): FMUD associated with CLM (500 mg twice a day) for 7 days. Clinical parameters were evaluated at baseline, 3, and 6 months post-treatment. The levels of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, and Fusobacterium nucleatum from subgingival biofilm were determined by quantitative polymerase chain reaction. RESULTS: Both treatments significantly improved all clinical parameters compared with baseline and promoted a significant reduction of A. actinomycetemcomitans and P. gingivalis counts (P > 0.05). CLM succeeded in decreasing T. forsythia at 6 months (P < 0.05), but no antibiotic was able to reduce F. nucleatum. There was no difference between the two protocols regarding the reported adverse effects (P > 0.05). CONCLUSIONS: The results suggest that CLM is not superior than AMX + MET in the treatment of GAgP. However, this antibiotic led to good clinical outcomes and may be a possible alternative to AMX+MET in the treatment of severe periodontitis in young patients. Future studies with larger sample sizes are needed to confirm this statement (NCT02969928). | - |
Descrição: dc.description | Division of Periodontics Institute of Science and Technology São Paulo State University (Unesp) | - |
Descrição: dc.description | Department of Prosthodontics and Periodontics Division of Periodontics Piracicaba Dental School University of Campinas (Unicamp) | - |
Descrição: dc.description | Division of Periodontics Institute of Science and Technology São Paulo State University (Unesp) | - |
Formato: dc.format | 1431-1440 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Journal of periodontology | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | aggressive periodontitis | - |
Palavras-chave: dc.subject | amoxicillin | - |
Palavras-chave: dc.subject | anti-infective agents | - |
Palavras-chave: dc.subject | clarithromycin | - |
Palavras-chave: dc.subject | metronidazole | - |
Palavras-chave: dc.subject | periodontal debridement | - |
Título: dc.title | Two different antibiotic protocols as adjuncts to one-stage full-mouth ultrasonic debridement to treat generalized aggressive periodontitis: A pilot randomized controlled clinical trial | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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