Two different antibiotic protocols as adjuncts to one-stage full-mouth ultrasonic debridement to treat generalized aggressive periodontitis: A pilot randomized controlled clinical trial

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.creatorAraujo, Cássia F [UNESP]-
Autor(es): dc.creatorAndere, Naira M R B [UNESP]-
Autor(es): dc.creatorCastro Dos Santos, Nídia C [UNESP]-
Autor(es): dc.creatorMathias-Santamaria, Ingrid F. [UNESP]-
Autor(es): dc.creatorReis, Aurélio A-
Autor(es): dc.creatorde Oliveira, Luciane D. [UNESP]-
Autor(es): dc.creatorJardini, Maria A N [UNESP]-
Autor(es): dc.creatorCasarin, Renato C V-
Autor(es): dc.creatorSantamaria, Mauro P. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:24:05Z-
Data de disponibilização: dc.date.available2022-02-22T00:24:05Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/JPER.18-0399-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/198275-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/198275-
Descrição: dc.descriptionBACKGROUND: To assess the clinical and microbiological responses of amoxicillin + metronidazole (AMX + MET) versus clarithromycin (CLM) as adjuncts to one-stage full-mouth ultrasonic debridement (FMUD) in the treatment of generalized aggressive periodontitis (GAgP). METHODS: For this parallel, double-masked, pilot randomized clinical trial, 46 patients with GAgP were selected and randomly assigned into two groups: AMX+MET group (n = 23): FMUD associated with AMX (500 mg three times a day) and MET (400 mg three times a day) for 7 days; and CLM group (n = 23): FMUD associated with CLM (500 mg twice a day) for 7 days. Clinical parameters were evaluated at baseline, 3, and 6 months post-treatment. The levels of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, and Fusobacterium nucleatum from subgingival biofilm were determined by quantitative polymerase chain reaction. RESULTS: Both treatments significantly improved all clinical parameters compared with baseline and promoted a significant reduction of A. actinomycetemcomitans and P. gingivalis counts (P > 0.05). CLM succeeded in decreasing T. forsythia at 6 months (P < 0.05), but no antibiotic was able to reduce F. nucleatum. There was no difference between the two protocols regarding the reported adverse effects (P > 0.05). CONCLUSIONS: The results suggest that CLM is not superior than AMX + MET in the treatment of GAgP. However, this antibiotic led to good clinical outcomes and may be a possible alternative to AMX+MET in the treatment of severe periodontitis in young patients. Future studies with larger sample sizes are needed to confirm this statement (NCT02969928).-
Descrição: dc.descriptionDivision of Periodontics Institute of Science and Technology São Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Prosthodontics and Periodontics Division of Periodontics Piracicaba Dental School University of Campinas (Unicamp)-
Descrição: dc.descriptionDivision of Periodontics Institute of Science and Technology São Paulo State University (Unesp)-
Formato: dc.format1431-1440-
Idioma: dc.languageen-
Relação: dc.relationJournal of periodontology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectaggressive periodontitis-
Palavras-chave: dc.subjectamoxicillin-
Palavras-chave: dc.subjectanti-infective agents-
Palavras-chave: dc.subjectclarithromycin-
Palavras-chave: dc.subjectmetronidazole-
Palavras-chave: dc.subjectperiodontal debridement-
Título: dc.titleTwo different antibiotic protocols as adjuncts to one-stage full-mouth ultrasonic debridement to treat generalized aggressive periodontitis: A pilot randomized controlled clinical trial-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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