Effects of different pre-operative doses of dexamethasone on alveolar repair in rats

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorBrazilian Navy-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversity of Araraquara (UNIARA)-
Autor(es): dc.contributorUniversidade Federal do Rio de Janeiro (UFRJ)-
Autor(es): dc.creatorde Lima, Thiago Soares-
Autor(es): dc.creatorde O P Ribeiro, Amanda [UNESP]-
Autor(es): dc.creatorSantos, Vinícius Bastos P.-
Autor(es): dc.creatorde Costa Neto, Oswaldo Castro-
Autor(es): dc.creatorMarques, Daniela Oliveira-
Autor(es): dc.creatorQueiroz, Thallita Pereira-
Autor(es): dc.creatorVisconti, Maria Augusta-
Autor(es): dc.creatorEsteves, Jônatas Caldeira-
Data de aceite: dc.date.accessioned2022-02-22T00:24:03Z-
Data de disponibilização: dc.date.available2022-02-22T00:24:03Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.archoralbio.2019.104624-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/198258-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/198258-
Descrição: dc.descriptionDexamethasone has been widly used in oral and maxillofacial surgery for controlling of postoperative surgical inflammation. Despite its clinical effectiveness, several studies have demonstrated the negative impact of this drug on the healing of soft and hard tissues. This study aimed to assess the effects of different pre-operative doses of dexamethasone on alveolar repair. Sixty rats were divided into four groups of 15 animals each. Single pre-operative doses of dexamethasone equivalent to human doses of 4 mg (Group 4 mg), 8 mg (Group 8 mg), and 12 mg (Group 12 mg), calculated by allometric dose extrapolation, were administered; and rats in the Control Group were injected with saline solution. The animals were anesthetized, and their left mandibular first molars (M1) were removed. After three, seven, and 40 days, 5 animals from each group were euthanized, and bone samples of M1 alveolus were collected for radipgraphic, histomorphological and histometric evaluation of the early and late phases of alveolar healing. At three days, Group 12 mg presented reduced radiographic density, percentage of collagen, and connective matrix compared with the Control Group. At 7 days, the percentage of bone was increased in the Control Group compared to Groups 8 mg and 12 mg (P < 0.05). It can be concluded that a single pre-operative dose of 12 mg of dexamethasone affected the early stages of alveolar repair in rats.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)-
Descrição: dc.descriptionOdontoclínica Geral da Marinha Brazilian Navy, Praça Barão de Ladario, 1 - Centro-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Dentistry, Av. Eng. Francisco José Longo, 777 - Jardim Sao Dimas-
Descrição: dc.descriptionSchool of Dentistry University of Araraquara (UNIARA), R. Carlos Gomes, 1338 - Centro-
Descrição: dc.descriptionSchool of Dentistry Federal University of Rio de Janeiro (UFRJ), R. Prof. Rodolpho Paulo Rocco, 325 - Cidade Universitária da Universidade Federal do Rio de Janeiro-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Dentistry, Av. Eng. Francisco José Longo, 777 - Jardim Sao Dimas-
Idioma: dc.languageen-
Relação: dc.relationArchives of Oral Biology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBone regeneration-
Palavras-chave: dc.subjectDental alveolus-
Palavras-chave: dc.subjectDexamethasone-
Título: dc.titleEffects of different pre-operative doses of dexamethasone on alveolar repair in rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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