Relationship between inflammation and the severity of Recurrent Respiratory Papillomatosis

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorHospital Herrera-Llerandi-
Autor(es): dc.contributorSão Paulo Federal University-
Autor(es): dc.creatorEl Achkar, Vivian Narana Ribeiro [UNESP]-
Autor(es): dc.creatorDuarte, Andressa-
Autor(es): dc.creatorCarlos, Román-
Autor(es): dc.creatorLeón, Jorge Esquiche-
Autor(es): dc.creatorRibeiro-Silva, Alfredo-
Autor(es): dc.creatorPignatari, Shirley Shizue Nagata-
Autor(es): dc.creatorKaminagakura, Estela [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:23:56Z-
Data de disponibilização: dc.date.available2022-02-22T00:23:56Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.amjoto.2019.102321-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/198226-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/198226-
Descrição: dc.descriptionObjective: To characterize inflammatory cells in Recurrent Respiratory Papillomatosis (RRP) and to correlate it with severity using the Derkay laryngoscopic scale. Materials and methods: The data and biopsies from 36 patients with Juvenile (JRRP) and 56 patients with Adult (ARRP) were collected and analyzed under light microscopy. The patients were separated into groups according to the Derkay index: ≥20 for the most severe and < 20 for the less severe cases. Immunohistochemical analysis using CD3, CD4, CD8, CD15, CD20, CD68, FoxP3 and MUM-1 antibodies was performed, and the inflammatory cells were quantified. All the clinicopathological characteristics and the results of the immunohistochemical analysis were compared among the groups proposed using the Chi-Square test and correlated through the Spearman correlation test. Results: The ARRP showed significantly higher quantities of CD3+, CD8+ and MUM1+ cells (p < .05) than the JRRP samples. The presence of CD15+ cells showed positive correlation with the Derkay index (p < .05), while the MUM-1+ cells showed an inverse correlation (p = .01). Conclusion: There are differences between the inflammatory cells population in the juvenile and adult groups and it can be related to disease severity.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Bioscience and Oral Diagnosis Institute of Science and Technology São Paulo State University - UNESP-
Descrição: dc.descriptionDepartment of Pathology Ribeirão Preto School of Medicine University of São Paulo-
Descrição: dc.descriptionPathology Department Hospital Herrera-Llerandi-
Descrição: dc.descriptionOral Pathology Department of Stomatology Public Oral Health and Forensic Dentistry School of Dentistry of Ribeirão Preto University of São Paulo-
Descrição: dc.descriptionDepartment of Pathology and Legal Medicine Ribeirão Preto School of Medicine University of São Paulo-
Descrição: dc.descriptionDepartment of Otorhinolaryngology and Head and Neck Surgery São Paulo Federal University-
Descrição: dc.descriptionDepartment of Bioscience and Oral Diagnosis Institute of Science and Technology São Paulo State University - UNESP-
Descrição: dc.descriptionFAPESP: 16/24019-0-
Idioma: dc.languageen-
Relação: dc.relationAmerican Journal of Otolaryngology - Head and Neck Medicine and Surgery-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectHuman papillomavirus-
Palavras-chave: dc.subjectInflammatory cells-
Palavras-chave: dc.subjectLaryngeal papillomatosis-
Palavras-chave: dc.subjectSquamous cell papillomatosis-
Título: dc.titleRelationship between inflammation and the severity of Recurrent Respiratory Papillomatosis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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