A low cost method for carbamazepine, ciprofloxacin and norfloxacin determination in pharmaceutical formulations based on spot-test and smartphone images

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorLamarca, Rafaela Silva [UNESP]-
Autor(es): dc.creatorLima Gomes, Paulo Clairmont Feitosa de [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:23:51Z-
Data de disponibilização: dc.date.available2022-02-22T00:23:51Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.microc.2019.104297-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/198192-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/198192-
Descrição: dc.descriptionThe use of digital image-based method to determine several compounds has been applied in the different fields of sciences and health area. Antibiotics and antiepileptics are used worldwide and require a strict monitoring. High cost methods using chromatographic techniques are commonly applied to the quality control of those pharmaceutical compounds. Therefore, the present study aims to present a simple and precise method to determine carbamazepine, ciprofloxacin and norfloxacin in pharmaceutical formulations using low-cost devices and digital images obtained by smartphone. Spot-tests and a box to capture the digital images were made in a 3D printer. The images were processed in the RGB system by Image J software to obtain the RGB channels signal values as analytical signal. The smartphone enabled quick and in situ analyzes, a limit of detection of 3.0, 1.0 and 1.0 mg L−1 and limit of quantification of 5.0, 3.0 and 3.0 mg L−1 were obtained for carbamazepine (CBZ), ciprofloxacin (CIP) and norfloxacin (NOR), respectively. The intra-day precision (RSD %) varied from 0.590 to 19.5 %. The developed method was compared to a method using spectrophotometry, and the results obtained by both methods were statistically equal. The proposed method allowed rapid analyzes, of about 16 s, low samples and chemical volume were required (8 µL), and a total cost of U$ 2.00. The developed method presents a new analytical tool, environmental friendly, portable and useful for labs with limited resources.-
Descrição: dc.descriptionInstituto Nacional de Ciência e Tecnologia em Toxinas-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionUnesp National Institute for Alternative Technologies of Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM) Institute of Chemistry, P.O. Box 355-
Descrição: dc.descriptionUnesp National Institute for Alternative Technologies of Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM) Institute of Chemistry, P.O. Box 355-
Descrição: dc.descriptionInstituto Nacional de Ciência e Tecnologia em Toxinas: 2014-50945-4-
Descrição: dc.descriptionFAPESP: 2016-03369-3-
Descrição: dc.descriptionFAPESP: 2018/22393-8-
Idioma: dc.languageen-
Relação: dc.relationMicrochemical Journal-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCarbamazepine-
Palavras-chave: dc.subjectCiprofloxacin-
Palavras-chave: dc.subjectDigital image-based method-
Palavras-chave: dc.subjectNorfloxacin-
Palavras-chave: dc.subjectSmartphone-
Palavras-chave: dc.subjectSpot-test-
Título: dc.titleA low cost method for carbamazepine, ciprofloxacin and norfloxacin determination in pharmaceutical formulations based on spot-test and smartphone images-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.