Cocrystals of ciprofloxacin with nicotinic and isonicotinic acids: Mechanochemical synthesis, characterization, thermal and solubility study

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorde Almeida, Amanda Cosmo [UNESP]-
Autor(es): dc.creatorTorquetti, Carolina [UNESP]-
Autor(es): dc.creatorFerreira, Patrícia Osório [UNESP]-
Autor(es): dc.creatorFernandes, Richard Perosa [UNESP]-
Autor(es): dc.creatordos Santos, Everton Carvalho [UNESP]-
Autor(es): dc.creatorKogawa, Ana Carolina [UNESP]-
Autor(es): dc.creatorCaires, Flávio Junior [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:23:35Z-
Data de disponibilização: dc.date.available2022-02-22T00:23:35Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.tca.2019.178346-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/198125-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/198125-
Descrição: dc.descriptionThis article describes the synthesis and characterization of new cocrystals of ciprofloxacin with nicotinic and isonicotinic acids as coformers. The cocrystals were obtained by a mechanochemical method (neat and liquid-assisted grinding). The characterization of the cocrystals was carried out using differential scanning calorimetry (DSC), thermogravimetry and simultaneous differential thermal analysis (TG-DTA), infrared spectroscopy (IR), and powder X-ray diffractometry (PXRD). Using these thermal, spectroscopic and diffractometric methods it was possible to verify the formation of the cocrystals, either with or without the addition of ethanol. Additionally, binary phase diagrams, constructed from the data of the DSC curves, confirmed the formation of the cocrystals and their stoichiometry; 1:1 (mol/mol) was determined as the optimal stoichiometric ratio. Furthermore, the formed cocrystals were capable of improving the aqueous solubility of the bioactive agent used in this study.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP)-
Descrição: dc.descriptionSchool of Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP)-
Descrição: dc.descriptionSchool of Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationThermochimica Acta-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCiprofloxacin-
Palavras-chave: dc.subjectCocrystal-
Palavras-chave: dc.subjectMechanochemical synthesis-
Palavras-chave: dc.subjectSolubility study-
Palavras-chave: dc.subjectThermal analysis-
Título: dc.titleCocrystals of ciprofloxacin with nicotinic and isonicotinic acids: Mechanochemical synthesis, characterization, thermal and solubility study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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