PD-1 regulates leishmanicidal activity and IL-17 in dogs with leishmaniasis

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorRebech, Gabriela Torres [UNESP]-
Autor(es): dc.creatorVenturin, Gabriela Lovizutto [UNESP]-
Autor(es): dc.creatorSiqueira Ito, Lucas Takeshi [UNESP]-
Autor(es): dc.creatorBragato, Jaqueline Poleto [UNESP]-
Autor(es): dc.creatorde Carvalho Fonseca, Bianca Stefanini [UNESP]-
Autor(es): dc.creatorMelo, Larrissa Martins [UNESP]-
Autor(es): dc.creatorCosta, Sidnei Ferro [UNESP]-
Autor(es): dc.creatorde Rezende Eugênio, Flávia [UNESP]-
Autor(es): dc.creatordos Santos, Paulo Sérgio Patto [UNESP]-
Autor(es): dc.creatorde Lima, Valéria Marçal Felix [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:23:32Z-
Data de disponibilização: dc.date.available2022-02-22T00:23:32Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.vetimm.2019.109970-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/198108-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/198108-
Descrição: dc.descriptionLeishmaniasis is an immunosuppressive disease caused by protozoa of the genus Leishmania, for which dogs are the domestic reservoir. The programmed cell death-1 molecule (PD-1) is highly expressed in leukocyte cells of dogs with leishmaniasis, and it promotes T lymphocyte exhaustion and suppression of cytokine secretion. Because PD-1 has a suppressive function regarding cell immunity, we evaluated the effect of PD-1 blocking antibodies on NO, ROS and interleukin 17 (IL-17) production and on parasite load in spleen leukocyte cultures from dogs with leishmaniasis. In vitro, PD-1 blocking promoted increased levels of intracellular NO and NO2 and reduced the levels of IL-17 in the culture supernatant, in addition to reducing the parasite load, but it did not change ROS levels. We conclude that PD-1 participates in the regulation of the immune response and that the blocking antibody is effective in restoring host microbicidal activity. This can be investigated in an immunotherapeutic study in the future.-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Veterinary Medicine-
Descrição: dc.descriptionDepartment of Surgery and Animal Reproduction São Paulo State University (UNESP) School of Veterinary Medicine, Rua Clovis Pestana, 793-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Veterinary Medicine-
Descrição: dc.descriptionDepartment of Surgery and Animal Reproduction São Paulo State University (UNESP) School of Veterinary Medicine, Rua Clovis Pestana, 793-
Idioma: dc.languageen-
Relação: dc.relationVeterinary Immunology and Immunopathology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCD279-
Palavras-chave: dc.subjectCytokines-
Palavras-chave: dc.subjectProtozoa-
Palavras-chave: dc.subjectSpleen leukocytes-
Título: dc.titlePD-1 regulates leishmanicidal activity and IL-17 in dogs with leishmaniasis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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