Sand fly synthetic sex-aggregation pheromone co-located with insecticide reduces the incidence of infection in the canine reservoir of visceral leishmaniasis: A stratified cluster randomised trial

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Autor(es): dc.contributorUniversity of Warwick-
Autor(es): dc.contributorKeele University-
Autor(es): dc.contributorLancaster University-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorInstituto Oswaldo Cruz-
Autor(es): dc.contributorUniversity of Warwick Science Park-
Autor(es): dc.contributorUniversity of California Davis-
Autor(es): dc.contributorNEIKER- Instituto Vasco de Investigación y Desarrollo Agrario-
Autor(es): dc.contributorUniversity of Greenwich-
Autor(es): dc.creatorCourtenay, Orin-
Autor(es): dc.creatorDilger, Erin-
Autor(es): dc.creatorCalvo-Bado, Leo A.-
Autor(es): dc.creatorKravar-Garde, Lidija-
Autor(es): dc.creatorCarter, Vicky-
Autor(es): dc.creatorBell, Melissa J.-
Autor(es): dc.creatorAlves, Graziella B. [UNESP]-
Autor(es): dc.creatorGoncalves, Raquel-
Autor(es): dc.creatorMakhdoomi, Muhammad M.-
Autor(es): dc.creatorGonzález, Mikel A.-
Autor(es): dc.creatorNunes, Caris M. [UNESP]-
Autor(es): dc.creatorBray, Daniel P.-
Autor(es): dc.creatorBrazil, Reginaldo P.-
Autor(es): dc.creatorHamilton, James G.C.-
Data de aceite: dc.date.accessioned2022-02-22T00:23:32Z-
Data de disponibilização: dc.date.available2022-02-22T00:23:32Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1371/journal.pntd.0007767-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/198104-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/198104-
Descrição: dc.descriptionObjective To evaluate the efficacy of a synthetic sex-aggregation pheromone of the sand fly vector Lu. longipalpis, co-located with residual insecticide, to reduce the infection incidence of Leishmania infantum in the canine reservoir. Methods A stratified cluster randomised trial was designed to detect a 50% reduction in canine incident infection after 24 months in 42 recruited clusters, randomly assigned to one of three intervention arms (14 cluster each): synthetic pheromone + insecticide, insecticide-impregnated dog collars, or placebo control. Infection incidence was measured by seroconversion to anti-Leishmania serum antibody, Leishmania parasite detection and canine tissue parasite loads. Changes in relative Lu. longipalpis abundance within households were measured by setting three CDC light traps per household. Results A total 1,454 seronegative dogs were followed-up for a median 15.2 (95% C.I.s: 14.6, 16.2) months per cluster. The pheromone + insecticide intervention provided 13% (95% C.I. 0%, 44.0%) protection against anti-Leishmania antibody seroconversion, 52% (95% C.I. 6.2%, 74.9%) against parasite infection, reduced tissue parasite loads by 53% (95% C.I. 5.4%, 76.7%), and reduced household female sand fly abundance by 49% (95% C.I. 8.2%, 71.3%). Variation in the efficacy against seroconversion varied between trial strata. Equivalent protection attributed to the impregnated-collars were 36% (95% C.I. 14.4%, 51.8%), 23% (95% C.I. 0%, 57.5%), 48% (95% C.I. 0%, 73.4%) and 43% (95% C.I. 0%, 67.9%), respectively. Comparison of the two interventions showed no statistically consistent differences in their efficacies; however, the errors were broad for all outcomes. Reductions in sand fly numbers were predominant where insecticide was located (chicken and dog sleeping sites), with no evidence of insecticide-induced repellence onto humans or dogs. Conclusion The synthetic pheromone co-located with insecticide provides protection particularly against canine L. infantum parasite transmission and sand fly vector abundance. The effect estimates are not dissimilar to those of the insecticide-impregnated collars, which are documented to reduce canine infection incidence, human infection and clinical VL disease incidence, in different global regions. The trialled novel lure-and-kill approach is a low-cost potential vector control tool against ZVL in the Americas.-
Descrição: dc.descriptionJohannes Gutenberg-Universität Mainz-
Descrição: dc.descriptionZeeman Institute and School of Life Sciences University of Warwick-
Descrição: dc.descriptionSchool of Life Sciences Institute of Science and Technology in Medicine Keele University-
Descrição: dc.descriptionDivision of Biomedical and Life Sciences Faculty of Health and Medicine Lancaster University-
Descrição: dc.descriptionFaculdade de Medicina Veterinária Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionLaboratório de Doenças Parasitárias Instituto Oswaldo Cruz-
Descrição: dc.descriptionMicropathology Ltd Venture Centre University of Warwick Science Park-
Descrição: dc.descriptionDepartment of Animal Health and Production São Paulo State University (UNESP) School of Veterinary Medicine-
Descrição: dc.descriptionSchool of Veterinary Medicine University of California Davis, Garrod Drive-
Descrição: dc.descriptionDepartment of Animal Health NEIKER- Instituto Vasco de Investigación y Desarrollo Agrario-
Descrição: dc.descriptionAgriculture Health and Environments Department Natural Resources Institute Faculty of Engineering and Science University of Greenwich-
Descrição: dc.descriptionFaculdade de Medicina Veterinária Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionDepartment of Animal Health and Production São Paulo State University (UNESP) School of Veterinary Medicine-
Descrição: dc.descriptionJohannes Gutenberg-Universität Mainz: WT091689MF-
Idioma: dc.languageen-
Relação: dc.relationPLoS Neglected Tropical Diseases-
???dc.source???: dc.sourceScopus-
Título: dc.titleSand fly synthetic sex-aggregation pheromone co-located with insecticide reduces the incidence of infection in the canine reservoir of visceral leishmaniasis: A stratified cluster randomised trial-
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Aparece nas coleções:Repositório Institucional - Unesp

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