Atenção: Todas as denúncias são sigilosas e sua identidade será preservada.
Os campos nome e e-mail são de preenchimento opcional
Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | University of Warwick | - |
Autor(es): dc.contributor | Keele University | - |
Autor(es): dc.contributor | Lancaster University | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | Instituto Oswaldo Cruz | - |
Autor(es): dc.contributor | University of Warwick Science Park | - |
Autor(es): dc.contributor | University of California Davis | - |
Autor(es): dc.contributor | NEIKER- Instituto Vasco de Investigación y Desarrollo Agrario | - |
Autor(es): dc.contributor | University of Greenwich | - |
Autor(es): dc.creator | Courtenay, Orin | - |
Autor(es): dc.creator | Dilger, Erin | - |
Autor(es): dc.creator | Calvo-Bado, Leo A. | - |
Autor(es): dc.creator | Kravar-Garde, Lidija | - |
Autor(es): dc.creator | Carter, Vicky | - |
Autor(es): dc.creator | Bell, Melissa J. | - |
Autor(es): dc.creator | Alves, Graziella B. [UNESP] | - |
Autor(es): dc.creator | Goncalves, Raquel | - |
Autor(es): dc.creator | Makhdoomi, Muhammad M. | - |
Autor(es): dc.creator | González, Mikel A. | - |
Autor(es): dc.creator | Nunes, Caris M. [UNESP] | - |
Autor(es): dc.creator | Bray, Daniel P. | - |
Autor(es): dc.creator | Brazil, Reginaldo P. | - |
Autor(es): dc.creator | Hamilton, James G.C. | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:23:32Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:23:32Z | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2019-01-01 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1371/journal.pntd.0007767 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/198104 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/198104 | - |
Descrição: dc.description | Objective To evaluate the efficacy of a synthetic sex-aggregation pheromone of the sand fly vector Lu. longipalpis, co-located with residual insecticide, to reduce the infection incidence of Leishmania infantum in the canine reservoir. Methods A stratified cluster randomised trial was designed to detect a 50% reduction in canine incident infection after 24 months in 42 recruited clusters, randomly assigned to one of three intervention arms (14 cluster each): synthetic pheromone + insecticide, insecticide-impregnated dog collars, or placebo control. Infection incidence was measured by seroconversion to anti-Leishmania serum antibody, Leishmania parasite detection and canine tissue parasite loads. Changes in relative Lu. longipalpis abundance within households were measured by setting three CDC light traps per household. Results A total 1,454 seronegative dogs were followed-up for a median 15.2 (95% C.I.s: 14.6, 16.2) months per cluster. The pheromone + insecticide intervention provided 13% (95% C.I. 0%, 44.0%) protection against anti-Leishmania antibody seroconversion, 52% (95% C.I. 6.2%, 74.9%) against parasite infection, reduced tissue parasite loads by 53% (95% C.I. 5.4%, 76.7%), and reduced household female sand fly abundance by 49% (95% C.I. 8.2%, 71.3%). Variation in the efficacy against seroconversion varied between trial strata. Equivalent protection attributed to the impregnated-collars were 36% (95% C.I. 14.4%, 51.8%), 23% (95% C.I. 0%, 57.5%), 48% (95% C.I. 0%, 73.4%) and 43% (95% C.I. 0%, 67.9%), respectively. Comparison of the two interventions showed no statistically consistent differences in their efficacies; however, the errors were broad for all outcomes. Reductions in sand fly numbers were predominant where insecticide was located (chicken and dog sleeping sites), with no evidence of insecticide-induced repellence onto humans or dogs. Conclusion The synthetic pheromone co-located with insecticide provides protection particularly against canine L. infantum parasite transmission and sand fly vector abundance. The effect estimates are not dissimilar to those of the insecticide-impregnated collars, which are documented to reduce canine infection incidence, human infection and clinical VL disease incidence, in different global regions. The trialled novel lure-and-kill approach is a low-cost potential vector control tool against ZVL in the Americas. | - |
Descrição: dc.description | Johannes Gutenberg-Universität Mainz | - |
Descrição: dc.description | Zeeman Institute and School of Life Sciences University of Warwick | - |
Descrição: dc.description | School of Life Sciences Institute of Science and Technology in Medicine Keele University | - |
Descrição: dc.description | Division of Biomedical and Life Sciences Faculty of Health and Medicine Lancaster University | - |
Descrição: dc.description | Faculdade de Medicina Veterinária Universidade Estadual Paulista (UNESP) | - |
Descrição: dc.description | Laboratório de Doenças Parasitárias Instituto Oswaldo Cruz | - |
Descrição: dc.description | Micropathology Ltd Venture Centre University of Warwick Science Park | - |
Descrição: dc.description | Department of Animal Health and Production São Paulo State University (UNESP) School of Veterinary Medicine | - |
Descrição: dc.description | School of Veterinary Medicine University of California Davis, Garrod Drive | - |
Descrição: dc.description | Department of Animal Health NEIKER- Instituto Vasco de Investigación y Desarrollo Agrario | - |
Descrição: dc.description | Agriculture Health and Environments Department Natural Resources Institute Faculty of Engineering and Science University of Greenwich | - |
Descrição: dc.description | Faculdade de Medicina Veterinária Universidade Estadual Paulista (UNESP) | - |
Descrição: dc.description | Department of Animal Health and Production São Paulo State University (UNESP) School of Veterinary Medicine | - |
Descrição: dc.description | Johannes Gutenberg-Universität Mainz: WT091689MF | - |
Idioma: dc.language | en | - |
Relação: dc.relation | PLoS Neglected Tropical Diseases | - |
???dc.source???: dc.source | Scopus | - |
Título: dc.title | Sand fly synthetic sex-aggregation pheromone co-located with insecticide reduces the incidence of infection in the canine reservoir of visceral leishmaniasis: A stratified cluster randomised trial | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
O Portal eduCAPES é oferecido ao usuário, condicionado à aceitação dos termos, condições e avisos contidos aqui e sem modificações. A CAPES poderá modificar o conteúdo ou formato deste site ou acabar com a sua operação ou suas ferramentas a seu critério único e sem aviso prévio. Ao acessar este portal, você, usuário pessoa física ou jurídica, se declara compreender e aceitar as condições aqui estabelecidas, da seguinte forma: