Advances in ophthalmic preparation: the role of drug nanocrystals and lipid-based nanosystems

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorInstitute for Technological Research (IPT)-
Autor(es): dc.contributorUniversity of Alberta-
Autor(es): dc.creatorPeters, Maria Christina Camasmie-
Autor(es): dc.creatorSantos Neto, Edson dos-
Autor(es): dc.creatorMonteiro, Lis Marie-
Autor(es): dc.creatorYukuyama, Megumi Nishitani-
Autor(es): dc.creatorMachado, Marcella Gabrielle Mendes [UNESP]-
Autor(es): dc.creatorde Oliveira, Isabela Fernandes-
Autor(es): dc.creatorZanin, Maria Helena Ambrosio-
Autor(es): dc.creatorLöbenberg, Raimar-
Autor(es): dc.creatorBou-Chacra, Nádia-
Data de aceite: dc.date.accessioned2022-02-22T00:23:23Z-
Data de disponibilização: dc.date.available2022-02-22T00:23:23Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-03-15-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/1061186X.2019.1663858-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/198046-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/198046-
Descrição: dc.descriptionNanocrystals and lipid-based nanosystems have the potential to play a crucial role in a significant shift in the treatment of ophthalmic diseases. These drug delivery systems allow overcoming the barriers imposed by anatomy and physiology of the organ of vision. This review aims to present new perspectives for these innovative preparations, emphasising the applications of the nanocrystal and lipid-based nanosystem while outlining their advantages and the drawbacks. The in vivo performance of the lipid-based nanosystems was highlighted. Lipid-based nanosystems and nanocrystals showed a prolonged effect, improved ocular bioavailability, upper therapeutic efficacy, higher permeation, prolonged residence time, and sustained drug release, compared to the current applications. Well-established and innovative developments updates of these systems are highlighted herein.-
Descrição: dc.descriptionFaculty of Pharmaceutical Sciences Department of Pharmacy University of Sao Paulo-
Descrição: dc.descriptionOphthalmology Division Clinical Hospital of the Faculty of Medicine University of São Paulo-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionInstitute for Technological Research (IPT)-
Descrição: dc.descriptionDivision of Pharmaceutical Sciences Faculty of Pharmacy & Pharmaceutical Sciences Katz Group-Rexall Centre for Pharmacy & Health Research University of Alberta-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP)-
Formato: dc.format259-270-
Idioma: dc.languageen-
Relação: dc.relationJournal of Drug Targeting-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectdrug delivery-
Palavras-chave: dc.subjectlipid-based nanosystems-
Palavras-chave: dc.subjectNanocrystals-
Palavras-chave: dc.subjectocular bioavailability-
Palavras-chave: dc.subjectophthalmic-
Título: dc.titleAdvances in ophthalmic preparation: the role of drug nanocrystals and lipid-based nanosystems-
Aparece nas coleções:Repositório Institucional - Unesp

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