The effects of aging on rho-kinase and insulin signaling in skeletal muscle and white adipose tissue of rats

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Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorMuñoz, Vitor Rosetto-
Autor(es): dc.creatorGaspar, Rafael Calais-
Autor(es): dc.creatorKuga, Gabriel Keine-
Autor(es): dc.creatorPavan, Isadora Carolina Betim-
Autor(es): dc.creatorSimabuco, Fernando Moreira-
Autor(es): dc.creatorDa Silva, Adelino Sanchez Ramos-
Autor(es): dc.creatorDe Moura, Leandro Pereira [UNESP]-
Autor(es): dc.creatorCintra, Dennys Esper-
Autor(es): dc.creatorRopelle, Eduardo Rochete-
Autor(es): dc.creatorPauli, José Rodrigo-
Data de aceite: dc.date.accessioned2022-02-22T00:23:22Z-
Data de disponibilização: dc.date.available2022-02-22T00:23:22Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-02-13-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1093/gerona/gly293-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/198040-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/198040-
Descrição: dc.descriptionThe insulin receptor substrate 1 regulates insulin-mediated glucose uptake and is a target of Rho-kinase (Rock); however, the relationship between age-related insulin resistance and Rock signaling specifically in skeletal muscle and adipose tissue is unknown. We evaluated the content and activity of Rock in C2C12 myotubes, and in skeletal muscle and white adipose tissue (WAT) from two rodent models that differ in their patterns of body fat accumulation during aging (Wistar and Fischer 344 rats). Body fat gain in the Wistar rats was greater than in Fischer rats and only Wistar rats had impairment of whole-body insulin sensitivity. Rock activity and insulin signaling were impaired in skeletal muscle in both rat models, but only middle-aged Wistar rats had higher Rock activity in WAT. These data are consistent with a positive role of Rock in regulating insulin signaling in both skeletal muscle and its negative role in the adipose tissue, suggesting that Rock activity in adipose tissue is important in age-related insulin resistance.-
Descrição: dc.descriptionLaboratory of Molecular Biology of Exercise University of Campinas (UNICAMP)-
Descrição: dc.descriptionLaboratory of Functional Properties in Foods School of Applied Sciences (FCA) University of Campinas (UNICAMP)-
Descrição: dc.descriptionPostgraduate Program in Rehabilitation and Functional Performance Ribeirão Preto Medical School Usp-
Descrição: dc.descriptionSchool of Physical Education and Sport of Ribeirão Preto University of São Paulo (USP)-
Descrição: dc.descriptionOcrc - Obesity and Comorbidities Research Center University of Campinas (UNICAMP)-
Descrição: dc.descriptionPostgraduate Program in Motor Science - São Paulo State University (UNESP)-
Descrição: dc.descriptionCepece - Center of Research in Sport Sciences School of Applied Sciences University of Campinas (UNICAMP)-
Descrição: dc.descriptionLaboratory of Nutritional Genomics University of Campinas (UNICAMP)-
Descrição: dc.descriptionPostgraduate Program in Motor Science - São Paulo State University (UNESP)-
Formato: dc.format432-436-
Idioma: dc.languageen-
Relação: dc.relationJournals of Gerontology - Series A Biological Sciences and Medical Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAdipose tissue-
Palavras-chave: dc.subjectAging-
Palavras-chave: dc.subjectInsulin signaling-
Palavras-chave: dc.subjectMuscle-
Palavras-chave: dc.subjectRho-kinase-
Título: dc.titleThe effects of aging on rho-kinase and insulin signaling in skeletal muscle and white adipose tissue of rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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