Protective effect of tomato-oleoresin supplementation on oxidative injury recoveries cardiac function by improving β-adrenergic response in a diet-obesity induced model

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversity of Milan-
Autor(es): dc.creatorFerron, Artur Junio Togneri [UNESP]-
Autor(es): dc.creatorAldini, Giancarlo-
Autor(es): dc.creatorFrancisqueti-Ferron, Fabiane Valentini [UNESP]-
Autor(es): dc.creatorDe Almeida Silva, Carol Cristina Vágula [UNESP]-
Autor(es): dc.creatorBazan, Silmeia Garcia Zanati [UNESP]-
Autor(es): dc.creatorGarcia, Jéssica Leite [UNESP]-
Autor(es): dc.creatorDe Campos, Dijon Henrique Salomé [UNESP]-
Autor(es): dc.creatorGhiraldeli, Luciana [UNESP]-
Autor(es): dc.creatorKitawara, Koody Andre Hassemi [UNESP]-
Autor(es): dc.creatorAltomare, Alessandra-
Autor(es): dc.creatorCorrea, Camila Renata [UNESP]-
Autor(es): dc.creatorMoreto, Fernando [UNESP]-
Autor(es): dc.creatorFerreira, Ana Lucia A. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:23:16Z-
Data de disponibilização: dc.date.available2022-02-22T00:23:16Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/antiox8090368-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/198008-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/198008-
Descrição: dc.descriptionThe system redox imbalance is one of the pathways related to obesity-related cardiac dysfunction. Lycopene is considered one of the best antioxidants. The aim of this study was to test if the tomato-oleoresin would be able to recovery cardiac function by improving β-adrenergic response due its antioxidant effect. A total of 40 animals were randomly divided into two experimental groups to receive either the control diet (Control, n = 20) or a high sugar-fat diet (HSF, n = 20) for 20 weeks. Once cardiac dysfunction was detected by echocardiogram in the HSF group, animals were re- divided to begin the treatment with Tomato-oleoresin or vehicle, performing four groups: Control (n = 6); (Control + Ly, n = 6); HSF (n = 6) and (HSF + Ly, n = 6). Tomato oleoresin (10 mg lycopene/kg body weight (BW) per day) was given orally every morning for a 10-week period. The analysis included nutritional and plasma biochemical parameters, systolic blood pressure, oxidative parameters in plasma, heart, and cardiac analyses in vivo and in vitro. A comparison among the groups was performed by two-way analysis of variance (ANOVA). Results: The HSF diet was able to induce obesity, insulin-resistance, cardiac dysfunction, and oxidative damage. However, the tomato-oleoresin supplementation improved insulin-resistance, cardiac remodeling, and dysfunction by improving the β-adrenergic response. It is possible to conclude that tomato-oleoresin is able to reduce the oxidative damage by improving the system’s β-adrenergic response, thus recovering cardiac function.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionMedical School Sao Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Pharmaceutical Sciences University of Milan-
Descrição: dc.descriptionMedical School Sao Paulo State University (Unesp)-
Descrição: dc.descriptionCNPq: 424209/2016-0-
Idioma: dc.languageen-
Relação: dc.relationAntioxidants-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCardiac dysfunction-
Palavras-chave: dc.subjectHigh sugar-fat diet-
Palavras-chave: dc.subjectLycopene-
Palavras-chave: dc.subjectObesity-
Palavras-chave: dc.subjectTomato-oleoresin-
Palavras-chave: dc.subjectβ-adrenergic system-
Título: dc.titleProtective effect of tomato-oleoresin supplementation on oxidative injury recoveries cardiac function by improving β-adrenergic response in a diet-obesity induced model-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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