Predicting hemorrhagic transformation in patients not submitted to reperfusion therapies

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Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.contributorColumbia Univ-
Autor(es): dc.contributorUniv Fortaleza-
Autor(es): dc.contributorHosp Geral Fortaleza-
Autor(es): dc.contributorUniv Fed Ceara-
Autor(es): dc.contributorUniversidade Federal da Bahia (UFBA)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorHosp Inst Neurol Curitiba-
Autor(es): dc.contributorHosp Israelita Brasileiro Albert Einstein-
Autor(es): dc.creatorAndrade, Joao Brainer Clares de-
Autor(es): dc.creatorMohr, Jay P.-
Autor(es): dc.creatorLima, Fabricio Oliveira-
Autor(es): dc.creatorCarvalho, Joao Jose de Freitas-
Autor(es): dc.creatorFarias, Victor Aguiar Evangelista de-
Autor(es): dc.creatorOliveira-Filho, Jamary-
Autor(es): dc.creatorPontes-Neto, Octavio Marques-
Autor(es): dc.creatorBazan, Rodrigo [UNESP]-
Autor(es): dc.creatorMerida, Kristel Larisa Back-
Autor(es): dc.creatorFranciscato, Luisa-
Autor(es): dc.creatorPires, Matheus Mendes-
Autor(es): dc.creatorModolo, Gabriel Pinheiro [UNESP]-
Autor(es): dc.creatorMarques, Mayara Silva-
Autor(es): dc.creatorMiranda, Renata Carolina Acri Nunes-
Autor(es): dc.creatorSilva, Gisele Sampaio-
Data de aceite: dc.date.accessioned2022-02-22T00:22:43Z-
Data de disponibilização: dc.date.available2022-02-22T00:22:43Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2020.104940-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/197895-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/197895-
Descrição: dc.descriptionBackground: Well studied in patients with ischemic stroke after reperfusion thera-pies (RT), hemorrhagic transformation (HT) is also common in patients not treated with RT and can lead to disability even in initially asymptomatic cases. The best predictors of HT in patients not treated with RT are not well established. Therefore, we aimed to identify predictors of HT in patients not submitted to RT and create a user-friendly predictive score (PROpHET). Material and Methods: Patients admitted to a Comprehensive Stroke Center from 2015 to 2017 were prospectively evaluated and randomly selected to the derivation cohort. A multivariable logistic regression modeling was built to produce a predictive grading score for HT. The external vali-dation was assessed using datasets from 7 Comprehensive Stroke Centers using the area under the receiver operating characteristic curve (AUROC). Results: In the derivation group, 448 patients were included in the final analysis. The validation group included 2,683 patients. The score derived from significant predictors of HT in the multivariate logistic regression analysis was male sex (1 point), ASPECTS <= 7 (2 points), presence of leukoaraiosis (1 point), hyperdense cerebral middle artery sign (1 point), glycemia at admission >= 180 mg/dL (1 point), cardioembolism (1 point) and lacunar syndrome (-3 points) as a protective factor. The grading score ranges from -3 to 7. A Score >= 3 had 78.2% sensitivity and 75% specificity, and AUROC of 0.82 for all cases of HT. In the validation cohort, our score had an AUROC of 0.83. Conclusions: The PROpHET is a simple, quick, cost-free, and easy-to-perform tool that allows risk stratification of HT in patients not submitted to RT. A cost-free computerized version of our score is available online with a user-friendly interface.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionUniv Fed Sao Paulo, Rua Napoleao Barros 715, Sao Paulo, SP, Brazil-
Descrição: dc.descriptionColumbia Univ, Doris & Stanley Tananbaum Stroke Ctr, Neurol Inst New York, 710 W 168th St,6TH Floor,NI 614, New York, NY 10032 USA-
Descrição: dc.descriptionUniv Fortaleza, Fortaleza, Cear, Brazil-
Descrição: dc.descriptionHosp Geral Fortaleza, Fortaleza, Ceara, Brazil-
Descrição: dc.descriptionUniv Fed Ceara, Campus Quixada, Quixada, CE, Brazil-
Descrição: dc.descriptionUniv Fed Bahia, Salvador, BA, Brazil-
Descrição: dc.descriptionUniv Sao Paulo, Ribeirao Preto, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Sao Paulo, Brazil-
Descrição: dc.descriptionHosp Inst Neurol Curitiba, Curitiba, Parana, Brazil-
Descrição: dc.descriptionHosp Geral Fortaleza, Rua Avila Goulart 900, Fortaleza, CE, Brazil-
Descrição: dc.descriptionPraca 15 Novembro SN, Salvador, BA, Brazil-
Descrição: dc.descriptionHosp Clin, Floor 4th, Ribeirao Preto, SP, Brazil-
Descrição: dc.descriptionAv Prof Mario Rubens Guimaraes Montenegro, Botucatu, SP, Brazil-
Descrição: dc.descriptionR Jeremias Maciel Perretto 300, Curitiba, PR, Brazil-
Descrição: dc.descriptionHosp Israelita Brasileiro Albert Einstein, Rua Albert Einstein 627, Sao Paulo, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Sao Paulo, Brazil-
Formato: dc.format10-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier B.V.-
Relação: dc.relationJournal Of Stroke & Cerebrovascular Diseases-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectIschemic stroke-
Palavras-chave: dc.subjectHemorrhagic transformation-
Palavras-chave: dc.subjectComplicationVascular neurology-
Título: dc.titlePredicting hemorrhagic transformation in patients not submitted to reperfusion therapies-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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