Comprehensive Characterization of Titania Nanotubes Fabricated on Ti-Nb Alloys: Surface Topography, Structure, Physicomechanical Behavior, and a Cell Culture Assay

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Autor(es): dc.contributorNatl Res Tomsk Polytech Univ-
Autor(es): dc.contributorPeter Great St Petersburg Polytech Univ-
Autor(es): dc.contributorFirst IP Pavlov State Med Univ St Petersburg-
Autor(es): dc.contributorGR Derzhavin Tambov State Univ-
Autor(es): dc.contributorIHCE-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorChernozem, Roman V.-
Autor(es): dc.creatorSurmeneva, Maria A.-
Autor(es): dc.creatorIgnatov, Viktor P.-
Autor(es): dc.creatorPeltek, Oleksii O.-
Autor(es): dc.creatorGoncharenko, Alexander A.-
Autor(es): dc.creatorMuslimov, Albert R.-
Autor(es): dc.creatorTimin, Alexander S.-
Autor(es): dc.creatorTyurin, Alexander I.-
Autor(es): dc.creatorIvanov, Yurii F.-
Autor(es): dc.creatorGrandini, Carlos R. [UNESP]-
Autor(es): dc.creatorSurmenev, Roman A.-
Data de aceite: dc.date.accessioned2022-02-22T00:17:50Z-
Data de disponibilização: dc.date.available2022-02-22T00:17:50Z-
Data de envio: dc.date.issued2020-12-10-
Data de envio: dc.date.issued2020-12-10-
Data de envio: dc.date.issued2020-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1021/acsbiomaterials.9b01857-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/197697-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/197697-
Descrição: dc.descriptionIn this study, hybrid composites based on beta-alloy Ti-xNb and oxide nanotubes (NTs) have been successfully prepared. NTs of different sizes were grown on Ti-Nb substrates with different Nb contents (5, 25, and 50 wt %) via electrochemical anodization at 30 and 60 V. Scanning electron microscopy imaging revealed that vertically aligned nanotubular structures form on the surface of Ti-Nb alloy substrates and influence Nb content in alloys based on NT length. X-ray diffraction analysis confirmed the formation of the anodized TiO2 layer and revealed several phases as the Nb content increased, starting with alpha' for low Nb content (5 wt %), the martensite alpha '' for intermediate Nb content (25 wt %), and the beta phase for the highest Nb content (50 wt %). Nanoindentation testing was used to evaluate the changes in mechanical properties of oxide NTs grown on Ti-Nb alloys with different compositions. NT arrays showed wide variations in Young's modulus and hardness depending upon the anodization voltage and the Nb content. The hardness and Young's modulus strongly correlated with NT morphology and structure. The highly dense morphology formed at a lower anodization voltage results in increased elastic modulus and hardness values compared with the surfaces prepared at higher anodization voltages. The nanostructurization of Ti-Nb surface substrates favored improved surface properties for the enhanced adhesion and proliferation of human mesenchymal stem cells (hMSCs). In vitro adhesion, spreading, and proliferation of hMSCs revealed the improved surface properties of the NTs prepared at an anodization voltage of 30 V compared with the NTs prepared at 60 V. Thus it can be concluded that NTs with diameters of similar to 50 nm (at 30 V) are more favorable for cell adhesion and growth compared with NTs with diameters of 80 +/- 20 nm (at 60 V). The surfaces of Ti-25Nb substrates anodized at 30 V promoted enhanced cell growth, as the further increase in Nb content in Ti-Nb substrate (Ti-50Nb) led to reduced cell proliferation. The application of NTs on Ti-Nb substrates leads to significant reductions in mechanical properties compared with those on the Ti-Nb alloy and improves cell adhesion and proliferation, which is vitally important for successful application in regenerative medicine.-
Descrição: dc.descriptionRussian Science Foundation-
Descrição: dc.descriptionRFBR (Russian Foundation for Basic Research)-
Descrição: dc.descriptionTomsk Polytechnic University Competitiveness Enhancement Program-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionNatl Res Tomsk Polytech Univ, Phys Mat Sci & Composite Mat Ctr, Tomsk 634050, Russia-
Descrição: dc.descriptionNatl Res Tomsk Polytech Univ, Kizhner Res Ctr, Tomsk 634050, Russia-
Descrição: dc.descriptionPeter Great St Petersburg Polytech Univ, RASA Ctr, St Petersburg 195251, Russia-
Descrição: dc.descriptionFirst IP Pavlov State Med Univ St Petersburg, St Petersburg 197022, Russia-
Descrição: dc.descriptionGR Derzhavin Tambov State Univ, Res Inst Nanotechnol & Nanomat, Tambov 392000, Russia-
Descrição: dc.descriptionIHCE, Tomsk 634055, Russia-
Descrição: dc.descriptionUniv Estadual Paulista, Dept Fes, BR-17033360 Bauru, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Dept Fes, BR-17033360 Bauru, SP, Brazil-
Descrição: dc.descriptionRussian Science Foundation: 15-13-00043-
Descrição: dc.descriptionRFBR (Russian Foundation for Basic Research): 18-33-20076-
Descrição: dc.descriptionRFBR (Russian Foundation for Basic Research): 18-29-17047-
Descrição: dc.descriptionFAPESP: 2015/50.280-5-
Descrição: dc.descriptionCNPq: 308.204/2017-4-
Formato: dc.format1487-1499-
Idioma: dc.languageen-
Publicador: dc.publisherAmer Chemical Soc-
Relação: dc.relationAcs Biomaterials Science & Engineering-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectimplant-
Palavras-chave: dc.subjectsurface modification-
Palavras-chave: dc.subjectTiNb alloy-
Palavras-chave: dc.subjectanodization-
Palavras-chave: dc.subjectnanotubes-
Título: dc.titleComprehensive Characterization of Titania Nanotubes Fabricated on Ti-Nb Alloys: Surface Topography, Structure, Physicomechanical Behavior, and a Cell Culture Assay-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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