Use of molecular markers can help to understand the genetic diversity of Babesia bovis

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)-
Autor(es): dc.contributorInst Zootecnia-
Autor(es): dc.creatorMarques Simas, Paulo Vitor [UNESP]-
Autor(es): dc.creatorBassetto, Cesar Cristiano [UNESP]-
Autor(es): dc.creatorGiglioti, Rodrigo-
Autor(es): dc.creatorOkino, Cintia Hiromi-
Autor(es): dc.creatorOliveira, Henrique Nunes de [UNESP]-
Autor(es): dc.creatorSena Oliveira, Marcia Cristina de-
Data de aceite: dc.date.accessioned2022-02-22T00:16:42Z-
Data de disponibilização: dc.date.available2022-02-22T00:16:42Z-
Data de envio: dc.date.issued2020-12-10-
Data de envio: dc.date.issued2020-12-10-
Data de envio: dc.date.issued2020-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.meegid.2019.104161-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/197660-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/197660-
Descrição: dc.descriptionCattle babesiosis is a tick-borne disease responsible for significant losses for the livestock industries in tropical areas of the world. These piroplasms are under constant control of the host immune system, which lead to a strong selective pressure for arising more virulent or attenuated phenotypes. Aiming to better understand the most critical genetic modifications in Babesia bovis genome, related to virulence, an in silico analysis was performed using DNA sequences from GenBank. Fourteen genes (sbp-2, sbp-4, trap, msa-1, msa-2b, msa-2c, Bv80 (or Bb-1), 18S rRNA, acs-1, ama-1, beta-tub, cp-2, p0, rap-1a) related to parasite infection and immunogenicity and ITS region were selected for alignment and comparison of several isolates of Babesia bovis from different geographic regions around the world. Among the 15 genes selected for the study of diversity, only 7 genes (sbp-2, sbp-4, trap, msa-1, msa-2b, msa-2c, Bv80) and the ITS region presented sufficient genetic variation for the studies of phylogeny. Despite this genetic diversity observed into groups, there was not sufficient information available to associate molecular markers with virulence of isolates. However, some genetic groups no were correlated with geographic region what could indicate some typical evolutionary characteristics in the relation between parasitehost. Further studies using these genes in herds presenting diverse clinical conditions are required. The better understanding of evolutionary mechanisms of the parasite may contribute to improve prophylactic and therapeutic measures. In this way, we suggest that genes used in our study are potential markers of virulence and attenuation and have to be analyzed with the use of sequences from animals that present clinical signs of babesiosis and asymptomatic carriers.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionBrazilian Agricultural Research Corporation-
Descrição: dc.descriptionUniv Estadual Paulista, Fac Ciencias Agr & Vet, Jaboticabal, SP, Brazil-
Descrição: dc.descriptionEmbrapa Pecuaria Sudeste, Sao Carlos, SP, Brazil-
Descrição: dc.descriptionInst Zootecnia, Ctr Pesquisa Genet & Reprod Anim, Nova Odessa, SP, Brazil-
Descrição: dc.descriptionWashington Luiz Rd,Km 234, BR-13560970 Sao Carlos, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Fac Ciencias Agr & Vet, Jaboticabal, SP, Brazil-
Descrição: dc.descriptionFAPESP: 2016/07216-7-
Descrição: dc.descriptionFAPESP: 2018/16582-2-
Descrição: dc.descriptionCNPq: 153231/2018-1-
Descrição: dc.descriptionBrazilian Agricultural Research Corporation: Embrapa SEG 02.12.02.008.00.00-
Formato: dc.format9-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier B.V.-
Relação: dc.relationInfection Genetics And Evolution-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectBabesia bovis-
Palavras-chave: dc.subjectMolecular markers-
Palavras-chave: dc.subjectDiversity-
Palavras-chave: dc.subjectVirulence-
Palavras-chave: dc.subjectAttenuation-
Título: dc.titleUse of molecular markers can help to understand the genetic diversity of Babesia bovis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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