Beyond the Biological Effect of a Chemically Characterized Poplar Propolis: Antibacterial and Antiviral Activity and Comparison with Flurbiprofen in Cytokines Release by LPS-Stimulated Human Mononuclear Cells

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Autor(es): dc.contributorUniv Siena-
Autor(es): dc.contributorUniv Florence-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorGoverna, Paolo-
Autor(es): dc.creatorCusi, Maria Grazia-
Autor(es): dc.creatorBorgonetti, Vittoria-
Autor(es): dc.creatorSforcin, Jose Mauricio [UNESP]-
Autor(es): dc.creatorTerrosi, Chiara-
Autor(es): dc.creatorBaini, Giulia-
Autor(es): dc.creatorMiraldi, Elisabetta-
Autor(es): dc.creatorBiagi, Marco-
Data de aceite: dc.date.accessioned2022-02-22T00:16:10Z-
Data de disponibilização: dc.date.available2022-02-22T00:16:10Z-
Data de envio: dc.date.issued2020-12-10-
Data de envio: dc.date.issued2020-12-10-
Data de envio: dc.date.issued2019-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/biomedicines7040073-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/197624-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/197624-
Descrição: dc.descriptionBee propolis, especially Euro-Asian poplar propolis, is among the most well-known natural products traditionally used to treat pharyngitis and minor wounds. The aim of this research was to investigate the pharmacological properties responsible for poplar propolis effectiveness using, for the first time, different in vitro approaches applied to a chemically characterized sample. The anti-inflammatory activity was compared with flurbiprofen by determining pro-inflammatory cytokines released by lipopolysaccharide-stimulated human peripheral blood mononuclear cells (PBMC). The antibacterial activity against Gram+ and Gram- bacteria was assessed, as well as antiviral effects on H1N1 influenza a virus. Poplar propolis (5 and 25 mu g/mL) exerted a concentration-dependent anti-inflammatory activity. In this range of concentrations, propolis effect was not inferior to flurbiprofen on cytokines released by lipopolysaccharide (LPS)-stimulated human PBMC. Poplar propolis was found to upregulate IL-6 and IL-1 beta in non-stimulated PBMC. S. aureus, S. pyogenes, and S. pneumoniae were the most susceptible bacterial strains with inhibitory concentrations ranging from 156 to 625 mu g/mL. A direct anti-influenza activity was not clearly seen. Effective anti-inflammatory concentrations of propolis were significantly lower than the antibacterial and antiviral ones and results suggested that the anti-inflammatory activity was the most important feature of poplar propolis linked to its rationale use in medicine.-
Descrição: dc.descriptionUniv Siena, Dept Biotechnol Chem & Pharm, Dept Excellence 2018 2022, I-53100 Siena, Italy-
Descrição: dc.descriptionUniv Siena, Dept Med Biotechnol, Microbiol Unit, I-53100 Siena, Italy-
Descrição: dc.descriptionUniv Florence, Dept Neurosci Psychol Pharmacol & Child Hlth, I-50139 Florence, Italy-
Descrição: dc.descriptionSao Paulo State Univ, Inst Biosci, BR-18618970 Botucatu, SP, Brazil-
Descrição: dc.descriptionUniv Siena, Dept Phys Sci Earth & Environm, I-53100 Siena, Italy-
Descrição: dc.descriptionSao Paulo State Univ, Inst Biosci, BR-18618970 Botucatu, SP, Brazil-
Formato: dc.format10-
Idioma: dc.languageen-
Publicador: dc.publisherMdpi-
Relação: dc.relationBiomedicines-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectpoplar propolis-
Palavras-chave: dc.subjectanti-inflammatory-
Palavras-chave: dc.subjectcytokines release-
Palavras-chave: dc.subjectflurbiprofen-
Palavras-chave: dc.subjectflavonoids-
Palavras-chave: dc.subjectantibacterial-
Palavras-chave: dc.subjectinfluenza virus-
Palavras-chave: dc.subjectneuraminidase-
Título: dc.titleBeyond the Biological Effect of a Chemically Characterized Poplar Propolis: Antibacterial and Antiviral Activity and Comparison with Flurbiprofen in Cytokines Release by LPS-Stimulated Human Mononuclear Cells-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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