Direct antiviral therapy for treatment of hepatitis C: A real-world study from Brazil

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorFundacao Hosp Estadual Acre-
Autor(es): dc.contributorHosp Portugues-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniv Fed Juiz de Fora-
Autor(es): dc.contributorUniversidade Federal do Rio de Janeiro (UFRJ)-
Autor(es): dc.contributorInst Neurol Curitiba SC Ltda-
Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.contributorUniv Fed Alagoas-
Autor(es): dc.contributorAmbulatorio Hepatites Virais Prefeitura Municipal-
Autor(es): dc.contributorHosp Albert Einstein-
Autor(es): dc.contributorCtr Referencia Especialidades Cent Ribeirao Preto-
Autor(es): dc.contributorUniv Fed Rio Grande do Sul-
Autor(es): dc.contributorCTA Sae Ambulatorio Hepatites Virais-
Autor(es): dc.contributorUniversidade Federal de Goiás (UFG)-
Autor(es): dc.contributorInst Infectol Emilio Ribas-
Autor(es): dc.contributorHosp Base Dist Fed-
Autor(es): dc.contributorAmbulatorio Hepatites Virais Feira Santana Prefei-
Autor(es): dc.contributorUniv Fed Paraiba-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorOliveira Lobato, Cirley Maria de-
Autor(es): dc.creatorCodes, Liana-
Autor(es): dc.creatorSilva, Giovanni Faria [UNESP]-
Autor(es): dc.creatorMeirelles Souza, Aecio Flavio-
Autor(es): dc.creatorMoraes Coelho, Henrique Sergio-
Autor(es): dc.creatorAlves Pedroso, Maria Lucia-
Autor(es): dc.creatorParise, Edison Roberto-
Autor(es): dc.creatorTojal de Barros Lima, Leila Maria Soares-
Autor(es): dc.creatorBorba, Luiz Augusto-
Autor(es): dc.creatorEvangelista, Andreia Silva-
Autor(es): dc.creatorFontes Rezende, Rosamar Eulira-
Autor(es): dc.creatorCheinquer, Hugo-
Autor(es): dc.creatorOba Kuniyoshi, Aline Satie-
Autor(es): dc.creatorAires, Rodrigo Sebba-
Autor(es): dc.creatorDias Quintela, Eloiza Helena-
Autor(es): dc.creatorCosta Mendes, Liliana Sampaio-
Autor(es): dc.creatorVosqui Nascimento, Fabio Carneiro-
Autor(es): dc.creatorMoraes de Medeiros Filho, Jose Eymard-
Autor(es): dc.creatorCardoso Gomes Ferraz, Maria Lucia-
Autor(es): dc.creatorAbdala, Edson-
Autor(es): dc.creatorBittencourt, Paulo Lisboa-
Autor(es): dc.creatorBrazilian Real-Life Study HCV Trea-
Data de aceite: dc.date.accessioned2022-02-22T00:14:46Z-
Data de disponibilização: dc.date.available2022-02-22T00:14:46Z-
Data de envio: dc.date.issued2020-12-10-
Data de envio: dc.date.issued2020-12-10-
Data de envio: dc.date.issued2019-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.aohep.2019.08.001-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/197553-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/197553-
Descrição: dc.descriptionIntroduction and objectives: Direct antiviral agents (DAAs) including sofosbuvir (SOF), daclatasvir (DCV), simeprevir ( SIM) and ombitasvir, paritaprevir and dasabuvir were introduced 2015 in Brazil for treatment of hepatitis C virus (HCV) infection. The aims of this study were to assess effectiveness and safety of HCV treatment with DAA in real-life world in a highly admixed population from Brazil. Materials and methods: All Brazilian reference centers for HCV treatment were invited to take part in a web-based registry, prospectively conducted by the Brazilian Society of Hepatology, to assess outcomes of HCV treatment in Brazil with DAAs. Data to be collected included demographics, disease severity and comorbidities, genotype (GT), viral load, DAA regimens, treatment side effects and sustained virological response (SVR). Results: 3939 patients (60% males, mean age 58 +/- 10 years) throughout the country were evaluated. Most had advanced fibrosis or cirrhosis, GT1 and were treated with SOF/DCV or SOF/SIM. Overall SVR rates were higher than 95%. Subjects with decompensated cirrhosis, GT2 and GT3 have lower SVR rates of 85%, 90% and 91%, respectively. Cirrhosis and decompensated cirrhosis in GT1 and male sex and decompensated cirrhosis in GT3 were significantly associated with no SVR. Adverse events (AD) and serious AD occurred in 18% and 5% of those subjects, respectively, but less than 1% of patients required treatment discontinuation. Conclusion: SOF-based DAA regimens are effective and safe in the heterogeneous highly admixed Brazilian population and could remain an option for HCV treatment at least in low-income countries. (C) 2019 Fundacion Clinica Medica Sur, A.C. Published by Elsevier Espana, S.L.U.-
Descrição: dc.descriptionFundacao Hosp Estadual Acre, Rio Branco, AC, Brazil-
Descrição: dc.descriptionHosp Portugues, Salvador, BA, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Botucatu, SP, Brazil-
Descrição: dc.descriptionUniv Fed Juiz de Fora, Juiz De Fora, MG, Brazil-
Descrição: dc.descriptionUniv Fed Rio de Janeiro, Rio De Janeiro, RJ, Brazil-
Descrição: dc.descriptionInst Neurol Curitiba SC Ltda, Curitiba, Parana, Brazil-
Descrição: dc.descriptionUniv Fed Sao Paulo, Sao Paulo, SP, Brazil-
Descrição: dc.descriptionUniv Fed Alagoas, Maceio, AL, Brazil-
Descrição: dc.descriptionAmbulatorio Hepatites Virais Prefeitura Municipal, Criciuma, SC, Brazil-
Descrição: dc.descriptionHosp Albert Einstein, Sao Paulo, SP, Brazil-
Descrição: dc.descriptionCtr Referencia Especialidades Cent Ribeirao Preto, Ribeirao Preto, SP, Brazil-
Descrição: dc.descriptionUniv Fed Rio Grande do Sul, Porto Alegre, RS, Brazil-
Descrição: dc.descriptionCTA Sae Ambulatorio Hepatites Virais, Maringa, PR, Brazil-
Descrição: dc.descriptionUniv Fed Goias, Goiania, Go, Brazil-
Descrição: dc.descriptionInst Infectol Emilio Ribas, Sao Paulo, SP, Brazil-
Descrição: dc.descriptionHosp Base Dist Fed, Brasilia, DF, Brazil-
Descrição: dc.descriptionAmbulatorio Hepatites Virais Feira Santana Prefei, Feira De Santana, BA, Brazil-
Descrição: dc.descriptionUniv Fed Paraiba, Joao Pessoa, Paraiba, Brazil-
Descrição: dc.descriptionUniv Sao Paulo, Sao Paulo, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Botucatu, SP, Brazil-
Formato: dc.format849-854-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier B.V.-
Relação: dc.relationAnnals Of Hepatology-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectChronic hepatitis C-
Palavras-chave: dc.subjectDirect antiviral agents-
Palavras-chave: dc.subjectHepatic fibrosis-
Palavras-chave: dc.subjectCirrhosis-
Título: dc.titleDirect antiviral therapy for treatment of hepatitis C: A real-world study from Brazil-
Tipo de arquivo: dc.typelivro digital-
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