beta-cyclodextrin complexation as an approach to enhance the biopharmaceutical properties of Norfloxacin B Hydrate

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniv Nacl Cordoba-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorSoledad Bueno, Maria-
Autor(es): dc.creatorChierentin, Lucas [UNESP]-
Autor(es): dc.creatorBongioanni, Agustina-
Autor(es): dc.creatorNunes Salgado, Herida Regina [UNESP]-
Autor(es): dc.creatorRaquel Longhi, Marcela-
Autor(es): dc.creatorGarnero, Claudia-
Data de aceite: dc.date.accessioned2022-02-22T00:13:53Z-
Data de disponibilização: dc.date.available2022-02-22T00:13:53Z-
Data de envio: dc.date.issued2020-12-10-
Data de envio: dc.date.issued2020-12-10-
Data de envio: dc.date.issued2019-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.carres.2019.107818-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/197513-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/197513-
Descrição: dc.descriptionBinary systems of Norfloxacin B Hydrate with beta-CD were explored by reliable biopharmaceutical studies as potential candidates for the preparation of drug delivery systems. Initially, studies of antimicrobial activity and solubility of the different polymorphic forms of Norfloxacin provided evidence to select Norfloxacin B Hydrate as the optimal solid form of Norfloxacin. Solid binary systems were preparing by kneading, freeze-drying, and physical mixture methods. The influence on the solubility, dissolution rate and chemical stability of Norfloxacin B Hydrate was investigated. These studies showed an increment of solubility and dissolution rate in physiological simulated fluids. However, the solid systems were moderated hygroscopically under accelerated storage conditions, which produces a destabilizing effect that accelerated the chemical reactivity of the drug in such conditions. Therefore, special cares must be considered in the manufacturing process and the packaging selection. Moreover, the experimental results proved that freeze-drying was not an appropriate method for the preparation. In conclusion, the Norfloxacin oral bioavailability can be improved with this binary systems, that could be applied in the production of an alternative pharmaceutical formulation of the drug.-
Descrição: dc.descriptionConsejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)-
Descrição: dc.descriptionUniversidad Nacional de Cordoba-
Descrição: dc.descriptionPACD-FCFAr-UNESP (Araraquara-Brazil)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionUniao Quimica (Minas Gerais-Brazil)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionSecretaria de Ciencia y Tecnologia de la Universidad Nacional de Cordoba (SECyT-UNC)-
Descrição: dc.descriptionUniv Nacl Cordoba, CONICET, Unidad Invest & Desarrollo Tecnol Farmaceut UNITE, Ciudad Univ X5000HUA, Cordoba, Argentina-
Descrição: dc.descriptionUniv Nacl Cordoba, Dept Ciencias Farmaceut, Fac Ciencias Quim, Ciudad Univ X5000HUA, Cordoba, Argentina-
Descrição: dc.descriptionUniv Estadual Paulista, Fac Ciencias Farmaceut, Rodovia Araraquara Jau,Km 1, BR-14801902 Araraquara, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Fac Ciencias Farmaceut, Rodovia Araraquara Jau,Km 1, BR-14801902 Araraquara, SP, Brazil-
Descrição: dc.descriptionFAPESP: 2010/13335-2-
Formato: dc.format6-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier B.V.-
Relação: dc.relationCarbohydrate Research-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectNorfloxacin-
Palavras-chave: dc.subjectPolymorphism-
Palavras-chave: dc.subjectBioassay-
Palavras-chave: dc.subjectCyclodextrin complexation-
Palavras-chave: dc.subjectSolubility-
Título: dc.titlebeta-cyclodextrin complexation as an approach to enhance the biopharmaceutical properties of Norfloxacin B Hydrate-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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