Novel iron complexes with quinoxaline N-1,N-4-dioxide derivatives: synthesis, characterization and antimycobacterial activity

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniv Republica-
Autor(es): dc.contributorUniv Navarra-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorTarallo, M. Belen-
Autor(es): dc.creatorUrquiola, Carolina-
Autor(es): dc.creatorMonge, Antonio-
Autor(es): dc.creatorPavan, Fernando R. [UNESP]-
Autor(es): dc.creatorLeite, Clarice Q. [UNESP]-
Autor(es): dc.creatorTorre, Maria H.-
Autor(es): dc.creatorGambino, Dinorah-
Autor(es): dc.creatorCollery, P.-
Autor(es): dc.creatorMaymard, I-
Autor(es): dc.creatorTheophanides, T.-
Autor(es): dc.creatorKhassanova, L.-
Autor(es): dc.creatorCollery, T.-
Data de aceite: dc.date.accessioned2022-02-22T00:12:19Z-
Data de disponibilização: dc.date.available2022-02-22T00:12:19Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2008-01-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/197384-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/197384-
Descrição: dc.descriptionThree new iron complexes with 3-aminoquinoxaline-2-carbonitrile N-1, N-4-dioxide derivatives (L) with stoichiometries [Fe(L1)(2)], [Fe(L1)(3)] and [Fe(L2)(3)]center dot 5H(2)O were synthesized and characterized. Both ligands and complexes showed in vitro activity against Mycobacterium. tuberculosis H(37)Rv (ATCC 27294) (MIC=3.9 mu g/mL for [Fe(L1)(2)] and [Fe(L2)(3)]center dot 5H(2)O and 7.8 mu g/mL for [Fe(L1)(3)]) with low citotoxicity. Two of the three complexes presented better activity than the free ligands, demonstrating that metal coordination can favorably modify the profile of antimycobacterial activity of 3-aminoquinoxaline-2-carbonitrile N-1,N-4-dioxide derivatives.-
Descrição: dc.descriptionCHLCC-
Descrição: dc.descriptionPEDECIBA Quimica-
Descrição: dc.descriptionUniv Republica, Fac Quim, Catedra Quim Inorgan, Gral Flores 2124,CC 1157, Montevideo 11800, Uruguay-
Descrição: dc.descriptionUniv Navarra, CIFA, Pamplona, Spain-
Descrição: dc.descriptionUnesp, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil-
Descrição: dc.descriptionUnesp, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil-
Formato: dc.format867-+-
Idioma: dc.languageen-
Publicador: dc.publisherJohn Libbey Eurotext-
Relação: dc.relationMetal Ions In Biology And Medicine, Vol 10-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectM. tuberculosis-
Palavras-chave: dc.subjectquinoxaline N-1,N-4-dioxides-
Palavras-chave: dc.subjectiron complexes-
Título: dc.titleNovel iron complexes with quinoxaline N-1,N-4-dioxide derivatives: synthesis, characterization and antimycobacterial activity-
Aparece nas coleções:Repositório Institucional - Unesp

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