Prognostic phenotypic classification for canine mammary tumors

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorFac Med Sao Jose Do Rio Preto-
Autor(es): dc.contributorAC Camargo Canc Ctr-
Autor(es): dc.creatorVarallo, Giovanna Rossi [UNESP]-
Autor(es): dc.creatorGelaleti, Gabriela Bottaro [UNESP]-
Autor(es): dc.creatorMaschio-Signorini, Larissa Bazela [UNESP]-
Autor(es): dc.creatorMoschetta, Marina Gobbe-
Autor(es): dc.creatorLopes, Juliana Ramos [UNESP]-
Autor(es): dc.creatorDe Nardi, Andrigo Barboza [UNESP]-
Autor(es): dc.creatorTinucci-Costa, Mirela [UNESP]-
Autor(es): dc.creatorRocha, Rafael Malagoli-
Autor(es): dc.creatorPires De Campos Zuccari, Debora Aparecida-
Data de aceite: dc.date.accessioned2022-02-22T00:11:53Z-
Data de disponibilização: dc.date.available2022-02-22T00:11:53Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2019-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3892/ol.2019.11052-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/197321-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/197321-
Descrição: dc.descriptionMammary neoplasms are a heterogeneous form of disease, and in order to determine its course and biological features with more accuracy, investigations based on tumor phenotypes are required. The aim of the present study was to propose and validate a phenotypic classification for canine mammary tumors and to assess any association between clinicopathological characteristics, survival and prognosis. For the immunohistochemistry analysis, the primary antibodies against estrogen receptor-alpha, progesterone receptor, human epidermal growth factor receptor 2 (HER-2)/neu and E-cadherin were used. A total of 110 canine mammary tumors were investigated; 42 tumors were classified as luminal A, 41 as luminal B, 17 as triple-negative and 10 as HER-2-positive. The luminal A and B phenotypes were associated with improved prognosis, whereas HER-2positive and triple-negative tumors were more aggressive, and exhibited a significant association with the occurrence of metastasis, a worse Tumor-Node-Metastasis classification and shorter survival time (P<0.05). In addition, there were different levels of E-cadherin expression intensity observed among the four tumor profiles investigated. Luminal A and B phenotypes presented an upregulation of E-cadherin compared with the HER-2 positive and triple-negative phenotypes (P<0.05). From the results of the present study, the proposed immunohistochemical panel and phenotypic classification techniques could be useful diagnostic tools with a good technical applicability in veterinary oncology. The analysis of E-cadherin expression in the panel of tumor markers allowed a more accurate classification for determining the biological features of the mammary tumor.-
Descrição: dc.descriptionConselho Nacional Cientifico e Tecnologico-
Descrição: dc.descriptionFundacao de Apoio a Pesquisa e Extensao de Sao Jose do Rio Preto-
Descrição: dc.descriptionUniv Estadual Paulista, Fac Agr & Vet Sci, BR-14884900 Jaboticabal, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Ins Biosci Letters & Exact Sci, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil-
Descrição: dc.descriptionFac Med Sao Jose Do Rio Preto, Dept Mol Biol, Lab Mol Invest Canc, 5418 Brigadeiro Faria Lima Ave, BR-15090000 Sao Jose Do Rio Preto, SP, Brazil-
Descrição: dc.descriptionAC Camargo Canc Ctr, Int Res Ctr, BR-01508010 Sao Paulo, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Fac Agr & Vet Sci, BR-14884900 Jaboticabal, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Ins Biosci Letters & Exact Sci, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil-
Descrição: dc.descriptionConselho Nacional Cientifico e Tecnologico: 140624/2013-
Descrição: dc.descriptionFundacao de Apoio a Pesquisa e Extensao de Sao Jose do Rio Preto: 208/2014-
Formato: dc.format6545-6553-
Idioma: dc.languageen-
Publicador: dc.publisherSpandidos Publ Ltd-
Relação: dc.relationOncology Letters-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectdogs-
Palavras-chave: dc.subjectE-cadherin-
Palavras-chave: dc.subjectmammary tumors-
Palavras-chave: dc.subjectphenotypes-
Palavras-chave: dc.subjectprognostic-
Título: dc.titlePrognostic phenotypic classification for canine mammary tumors-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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