Experimental selective choriocapillaris photothrombosis using a modified indocyanine green formulation

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Autor(es): dc.contributorHosp Olhos Araraquara-
Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniv Calif Irvine-
Autor(es): dc.creatorCardillo, J. A.-
Autor(es): dc.creatorJorge, R.-
Autor(es): dc.creatorCosta, R. A.-
Autor(es): dc.creatorNunes, S. M. T. [UNESP]-
Autor(es): dc.creatorLavinsky, D.-
Autor(es): dc.creatorKuppermann, B. D.-
Autor(es): dc.creatorTedesco, A. C. [UNESP]-
Autor(es): dc.creatorFarah, M. E.-
Data de aceite: dc.date.accessioned2022-02-22T00:11:49Z-
Data de disponibilização: dc.date.available2022-02-22T00:11:49Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2008-02-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1136/bjo.2007.129395-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/197299-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/197299-
Descrição: dc.descriptionBackground: This in vivo study assessed and compared the effectiveness of an aqueous indocyanine green (ICG) formulation (R-ICG) and a lipid ICG formulation (L-ICG) in occluding the rabbit choriocapillaris, and determined the singlet oxygen quantum yields and aggregation properties of both formulations in vitro. Methods: Singlet oxygen production and aggregation were compared. The eye fundus of 30 albino rabbits was irradiated 0-15 min after dye injection using an 810 nm diode laser. Fluorescein angiography and light microscopy were used to evaluate the safety and efficacy of R-ICG and L-ICG. Results: L-ICG decreased the dimerisation constant and the tendency of ICG to form aggregates, and increased the efficiency of ICG in generating singlet oxygen (R-ICG, Phi Delta= 0.120 and L-ICG, Phi Delta= 0.210). Using a 10 mg/kg dose, choriocapillaris occlusion was achieved at a light dose of 35.8 J/cm(2) with L-ICG and 71.6 J/cm(2) with R-ICG with minimal damage to the neurosensory retina. Conclusion: Restrictions to the use of ICG in aqueous solution, low singlet oxygen quantum yields and high aggregation tendency, were overcome with L-ICG. The lower laser irradiance required to obtain choriocapillaris occlusion may suggest that L-ICG is a more potent and selective photosensitiser than R-ICG.-
Descrição: dc.descriptionHosp Olhos Araraquara, Retinal Diagnost & Treatment Div, BR-14802530 Araraquara, SP, Brazil-
Descrição: dc.descriptionUniv Fed Sao Paulo, Paulista Sch Med, Dept Ophthalmol, Sao Paulo, Brazil-
Descrição: dc.descriptionState Univ Sao Paulo USP Ribeirao Preto, Dept Chem, Riberir Preto, Brazil-
Descrição: dc.descriptionUniv Calif Irvine, Dept Ophthalmol, Irvine, CA USA-
Descrição: dc.descriptionState Univ Sao Paulo USP Ribeirao Preto, Dept Chem, Riberir Preto, Brazil-
Formato: dc.format276-280-
Idioma: dc.languageen-
Publicador: dc.publisherBmj Publishing Group-
Relação: dc.relationBritish Journal Of Ophthalmology-
???dc.source???: dc.sourceWeb of Science-
Título: dc.titleExperimental selective choriocapillaris photothrombosis using a modified indocyanine green formulation-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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