Evaluation of cytoprotective effects of compounds isolated fromCopaifera langsdorffiiDesf. against induced cytotoxicity by exposure to methylmercury and lead

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniv Franca-
Autor(es): dc.creatorAldana, Jennyfer Andrea-
Autor(es): dc.creatorDe Grandis, Rone Aparecido [UNESP]-
Autor(es): dc.creatorNicolella, Heloiza-
Autor(es): dc.creatorGuissoni, Ana Paula Prado-
Autor(es): dc.creatorSquarisi, Iara-
Autor(es): dc.creatorArruda, Caroline-
Autor(es): dc.creatorRibeiro, Victor Pena-
Autor(es): dc.creatorTavares, Denise Crispim-
Autor(es): dc.creatorMazzaron Barcelos, Gustavo Rafael-
Autor(es): dc.creatorGreggi Antunes, Lusania Maria-
Autor(es): dc.creatorBastos, Jairo Kenupp-
Data de aceite: dc.date.accessioned2022-02-22T00:11:42Z-
Data de disponibilização: dc.date.available2022-02-22T00:11:42Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/14786419.2018.1543673-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/197253-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/197253-
Descrição: dc.descriptionCopaifera langsdorffiiL. is one of the most known medicinal species in Brazil. Its leaves are rich in phenolic compounds with potential biological activities as an antioxidant and chelating agent. This paper reports the isolation of four compounds from the hydroalcoholic extract of the leaves ofC. langsdorffiiand the investigation of their possible cytoprotective effects against heavy metal poisoning. Quercitrin (1), afzelin (2), 3,5-di-O-(3-O-methyl galloyl) quinic acid (3) and 4,5-di-O-(3-O-methyl galloyl) quinic acid (4), were associated with toxic doses of methylmercury and lead and evaluated by Alamar blue cell viability assays in HepG2 and PC12. The compounds displayed significant cytoprotective effect for the HepG2 cell line against both metals. Compounds 1-4 did not protect PC12 cells against methylmercury induced-cytotoxicity, but at lower concentrations, they protected against lead induced-cytotoxicity. The evaluated compounds showed a promising cytoprotection effect against exposure to heavy metals and should be further investigated as protective agents.-
Descrição: dc.descriptionUniv Sao Paulo, Dept Pharmaceut Sci, Ribeirao Preto, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Dept Biol Sci, Araraquara, SP, Brazil-
Descrição: dc.descriptionUniv Sao Paulo, Dept Clin Toxicol & Bromatol Anal, Ribeirao Preto, Brazil-
Descrição: dc.descriptionUniv Franca, Nucleus Res Sci & Technol, Franca, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Dept Biol Sci, Araraquara, SP, Brazil-
Formato: dc.format2528-2532-
Idioma: dc.languageen-
Publicador: dc.publisherTaylor & Francis Ltd-
Relação: dc.relationNatural Product Research-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectCopaifera langsdorffii-
Palavras-chave: dc.subjectCaesalpinaceae-
Palavras-chave: dc.subjectcytoprotection-
Palavras-chave: dc.subjectheavy metals-
Palavras-chave: dc.subjectflavonoids-
Palavras-chave: dc.subjectgalloylquinic compounds-
Título: dc.titleEvaluation of cytoprotective effects of compounds isolated fromCopaifera langsdorffiiDesf. against induced cytotoxicity by exposure to methylmercury and lead-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.