Incidence and characteristics of methicillin-resistant coagulase-negativeStaphylococcus aureusin peritoneal dialysis-associated peritonitis in a single center using molecular methods

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorAdolfo Lutz Inst-
Autor(es): dc.creatorCamargo, Carlos Henrique [UNESP]-
Autor(es): dc.creatorRibeiro de Souza da Cunha, Maria de Lourdes [UNESP]-
Autor(es): dc.creatorTeixeira Caramori, Jacqueline Costa [UNESP]-
Autor(es): dc.creatorMondelli, Alessandro Lia [UNESP]-
Autor(es): dc.creatorMontelli, Augusto Cezar [UNESP]-
Autor(es): dc.creatorBarretti, Pasqual [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:11:32Z-
Data de disponibilização: dc.date.available2022-02-22T00:11:32Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-08-17-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s11255-020-02605-9-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/197194-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/197194-
Descrição: dc.descriptionPurpose Peritonitis is a serious complication of peritoneal dialysis and coagulase-negativeStaphylococcus(CNS) is the most frequent cause of peritoneal dialysis (PD)-infections in many centers. This study aimed to investigate the molecular epidemiology of CNS isolated from PD-peritonitis in a Brazilian single center, focusing on the genetic determinants conferring methicillin resistance. Methods Bacterial strains were isolated from peritoneal fluid of patients presenting PD-peritonitis, identified by phenotypic and molecular methods, and those identified as CNS were submitted tomecAdetection, SCCmec, pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST). Results Over the 18-year period of this study (1995-2011), a total of 878 peritonitis episodes were diagnosed in this unit, 115 were caused by coagulase-negative staphylococci of which 72 byStaphylococcus epidermidis.mecAgene was detected in 55 CNS (47.8%), more frequently on the more recent years. SCCmectype III was the most frequent cassette, followed by SCCmectype IV and SCCmectype II. A diverstity of pulsotypes was observed among theS. epidermidisisolates, but five clusters (based on the 80% cutoff) were identified. Diversified sequence types (ST02, ST05, ST06, ST09, ST23, ST59 and ST371) were detected. Conclusions Detection of SCCmectype III among coagulase-negativeStaphylococcusunderscores the role of hospital environments as potential source of methicillin-resistantStaphylococcuscausing peritonitis in PD patients.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionWellcome Trust-
Descrição: dc.descriptionSao Paulo State Univ, Botucatu Med Sch, Dept Internal Med, Botucatu, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Biosci Inst Botucatu, Dept Microbiol & Immunol, Botucatu, SP, Brazil-
Descrição: dc.descriptionAdolfo Lutz Inst, Bacteriol Div, Ave Dr Arnaldo,351-9 Andar, Sao Paulo, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Botucatu Med Sch, Dept Internal Med, Botucatu, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Biosci Inst Botucatu, Dept Microbiol & Immunol, Botucatu, SP, Brazil-
Descrição: dc.descriptionFAPESP: 2009/15727-8-
Descrição: dc.descriptionFAPESP: 2009/12052-0-
Formato: dc.format8-
Idioma: dc.languageen-
Publicador: dc.publisherSpringer-
Relação: dc.relationInternational Urology And Nephrology-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectBacterial peritonitis-
Palavras-chave: dc.subjectmecA-
Palavras-chave: dc.subjectPeritoneal dialysis-
Palavras-chave: dc.subjectPFGE-
Palavras-chave: dc.subjectSccmec-
Palavras-chave: dc.subjectStaphylococcus epidermidis-
Título: dc.titleIncidence and characteristics of methicillin-resistant coagulase-negativeStaphylococcus aureusin peritoneal dialysis-associated peritonitis in a single center using molecular methods-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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