Rotary-jet spun polycaprolactone/nano-hydroxyapatite scaffolds modified by simulated body fluid influenced the flexural mode of the neoformed bone

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniv Brasil-
Autor(es): dc.contributorUninassau Univ-
Autor(es): dc.contributorUFPI Fed Univ Piaui-
Autor(es): dc.creatorVasconcellos, Luana M. R. [UNESP]-
Autor(es): dc.creatorElias, Conceicao de M. V.-
Autor(es): dc.creatorMinhoto, Giovanna B. [UNESP]-
Autor(es): dc.creatorAbdala, Julia M. A.-
Autor(es): dc.creatorAndrade, Telmo M.-
Autor(es): dc.creatorAraujo, Juliani C. R. de [UNESP]-
Autor(es): dc.creatorGusmao, Suziete Batista Soares-
Autor(es): dc.creatorViana, Bartolomeu C.-
Autor(es): dc.creatorMarciano, Fernanda R.-
Autor(es): dc.creatorLobo, Anderson O.-
Data de aceite: dc.date.accessioned2022-02-22T00:11:19Z-
Data de disponibilização: dc.date.available2022-02-22T00:11:19Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-07-27-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s10856-020-06403-8-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/197113-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/197113-
Descrição: dc.descriptionPolycaprolactone (PCL) is a biocompatible, biodegradable synthetic polymer which in combination with nanohydroxyapatite (nHAp) can give rise to a low cost, nontoxic bioactive product with excellent mechanical properties and slow degradation. Here we produced, characterized and evaluated in vivo the bone formation of PCL/nHAp scaffolds produced by the rotary jet spinning technique. The scaffolds produced were firstly soaked into simulated body fluid for 21 days to also obtain nHAp onto PCL/nHAp scaffolds. Afterwards, the scaffolds were characterized by scanning electron microscopy (SEM), energy dispersive spectroscopy and Raman spectroscopy. For in vivo experiments, 20 male Wistar rats were used and randomly divided in 4 experimental groups (n = 5). A critical defect of 3 mm in diameter was made in the tibia of the animals, which were filled with G1 control (clot); G2-PCL scaffold; G3-PCL/nHAp (5%) scaffold; G4-PCL/nHAp (20%) scaffold. All animals were euthanized 60 days after surgery, and the bone repair in the right tibiae were evaluated by radiographic analysis, histological analysis and histomorphometric analysis. While in the left tibias, the areas of bone repair were submitted to the flexural strength test. Radiographic and histomorphometric analyses no showed statistical difference in new bone formation between the groups, but in the three-point flexural tests, the PCL/nHAp (20%) scaffold positively influenced the flexural mode of the neoformed bone. These findings indicate that PCL/nHAp (20%) scaffold improve biomechanical properties of neoformed bone and could be used for bone medicine regenerative.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSao Paulo State Univ, Inst Sci & Technol, Dept Biosci & Oral Diag, BR-12245000 Sao Jose Dos Campos, SP, Brazil-
Descrição: dc.descriptionUniv Brasil, Inst Cient & Tecnol, BR-08230030 Sao Paulo, Brazil-
Descrição: dc.descriptionUninassau Univ, BR-64017775 Teresina, Piaui, Brazil-
Descrição: dc.descriptionUFPI Fed Univ Piaui, Dept Phys, BR-64017775 Teresina, Piaui, Brazil-
Descrição: dc.descriptionUFPI Fed Univ Piaui, Dept Mat Engn, LIMAV Interdisciplinary Lab Adv Mat, BioMatLab, BR-64049550 Teresina, Piaui, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Inst Sci & Technol, Dept Biosci & Oral Diag, BR-12245000 Sao Jose Dos Campos, SP, Brazil-
Descrição: dc.descriptionCNPq: 303752/2017-3-
Descrição: dc.descriptionCNPq: 404683/2018-5-
Descrição: dc.descriptionCNPq: 304133/2017-5-
Descrição: dc.descriptionCNPq: 424163/2016-0-
Descrição: dc.descriptionFAPESP: 2016/20820-0-
Formato: dc.format9-
Idioma: dc.languageen-
Publicador: dc.publisherSpringer-
Relação: dc.relationJournal Of Materials Science-materials In Medicine-
???dc.source???: dc.sourceWeb of Science-
Título: dc.titleRotary-jet spun polycaprolactone/nano-hydroxyapatite scaffolds modified by simulated body fluid influenced the flexural mode of the neoformed bone-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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